ID G3RR14_GORGO Unreviewed; 1036 AA.
AC G3RR14;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=PDZ domain containing ring finger 4 {ECO:0000313|Ensembl:ENSGGOP00000018238.1};
GN Name=PDZRN4 {ECO:0000313|Ensembl:ENSGGOP00000018238.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000018238.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000018238.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000018238.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000018238.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABD030084353; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030084354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030084355; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030084356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030084357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030084358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004053016.1; XM_004052968.2.
DR AlphaFoldDB; G3RR14; -.
DR STRING; 9593.ENSGGOP00000018238; -.
DR Ensembl; ENSGGOT00000032161.2; ENSGGOP00000018238.1; ENSGGOG00000025388.2.
DR GeneID; 101131183; -.
DR CTD; 29951; -.
DR eggNOG; KOG0297; Eukaryota.
DR eggNOG; KOG0312; Eukaryota.
DR GeneTree; ENSGT00950000183062; -.
DR InParanoid; G3RR14; -.
DR OMA; TMEQDYY; -.
DR OrthoDB; 2879659at2759; -.
DR TreeFam; TF315909; -.
DR Proteomes; UP000001519; Chromosome 12.
DR Bgee; ENSGGOG00000025388; Expressed in prefrontal cortex and 2 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 2.
DR CDD; cd16719; RING-HC_LNX4; 1.
DR Gene3D; 2.30.42.10; -; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR15545; PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4; 1.
DR PANTHER; PTHR15545:SF6; PDZ DOMAIN-CONTAINING RING FINGER PROTEIN 4; 1.
DR Pfam; PF00595; PDZ; 2.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR SMART; SM00228; PDZ; 2.
DR SMART; SM00184; RING; 1.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50106; PDZ; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 18..54
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 224..314
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 402..473
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 129..160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 659..686
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 552..570
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..590
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1036 AA; 117203 MW; F4D214196D8BE38D CRC64;
MGFALERFAE AVDPALKCKL CGQVLEEPLC TPCGHVFCAS CLLPWAVRRR RCPLQCQPLA
PGELYRVLPL RSLIQKLRVQ CDYRARGCGH SVRLHELEAH VEHCDFGPAR RLRSRRGCPS
ELGGGEVPAR GGCGPAPRAG RGGGARGGPP GGRCGRGRGP GPRVLAWRRR EKALLAQLWA
LQGEVQLTAR RYQEKFTQYM AHVRNFVGDL GGGHRRDGEH KPFTIVLERE NDTLGFNIIG
GRPNQNNQEG TSTEGIYVSK ILENGPADRA DGLEIHDKIM EVNGKDLSKA THEEAVEAFR
NAKEPIVVQV LRRTPLSRPA YGMASEVQLM NASTQTDITF EHIMALAKLR PPTPPVPDIC
PFLLSDSCHS LHPMEHEFYE DNEYISSLPA DADRTEDFEY EEVELCRVSS QEKLGLTVCY
RTDDEEDTGI YVSEVDPNSI AAKDGRIREG DRILQINGED VQNREEAVAL LSNDECKRIV
LLVARPEIQL DEGWLEDERN EFLEELNLEM LEEEHNETMQ PTANEVEQPK KQEEEEGTTD
TATSSSNNHE KDSGVGRTDE SLRNDESSEQ ENAAEDPNST SLKSKRDLGQ SQDTLGSVEL
QYNESLVSGE YIDSDCIGNQ DEDCERFRQL LELKCKIRNH GEYDLYYSSS TIECNQGEQE
GVEHELQLLN EELRNIELEC QNIMQAHRLQ KVTDQYGDIW TLHDGGFRNY NTSIDMQRGK
LDDIMEHPEK SDKDSSSAYN TAESCRSTPL TVDRSPDSSL PRVINLTNKK NLRSTMAATQ
SSSGQSSKES TSTKAKTTAQ GCSAESKEKI LEGSKLPDQE KAVSEHIPYL SPYHSSSYRY
ANIPAHARHY QSYMQLIQQK SAVEYAQSQL SLVSMCKESQ KCSEPKMEWK VKIRSDGTRY
ITKRPVRDRI LKERALKIKE ERSGMTTDDD TMSEMKMGRY WSKEERKQHL VRAKEQRRRR
EFMMRSRLEC LKESPQSGSE GKKEINIIEL SHKKMMKKRN KKILDNWMTI QELMTHGAKS
PDGTRVHNAF LSVTTV
//
