ID G3RRE7_GORGO Unreviewed; 1200 AA.
AC G3RRE7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Calmodulin binding transcription activator 2 {ECO:0000313|Ensembl:ENSGGOP00000018371.2};
GN Name=CAMTA2 {ECO:0000313|Ensembl:ENSGGOP00000018371.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000018371.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000018371.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000018371.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000018371.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: May interact with calmodulin. {ECO:0000256|ARBA:ARBA00029480}.
CC -!- SIMILARITY: Belongs to the CAMTA family.
CC {ECO:0000256|ARBA:ARBA00008267}.
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DR EMBL; CABD030103319; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030103320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030103321; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018868655.1; XM_019013110.1.
DR AlphaFoldDB; G3RRE7; -.
DR Ensembl; ENSGGOT00000031381.2; ENSGGOP00000018371.2; ENSGGOG00000009188.3.
DR GeneTree; ENSGT00940000160105; -.
DR HOGENOM; CLU_003170_2_0_1; -.
DR OrthoDB; 470813at2759; -.
DR Proteomes; UP000001519; Chromosome 17.
DR Bgee; ENSGGOG00000009188; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0060255; P:regulation of macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0051171; P:regulation of nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0080090; P:regulation of primary metabolic process; IEA:UniProt.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005559; CG-1_dom.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23335:SF9; CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 2; 1.
DR PANTHER; PTHR23335; CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR CAMTA; 1.
DR Pfam; PF03859; CG-1; 1.
DR Pfam; PF01833; TIG; 1.
DR SMART; SM01076; CG-1; 1.
DR SMART; SM00015; IQ; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51437; CG_1; 1.
DR PROSITE; PS50096; IQ; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transcription {ECO:0000256|ARBA:ARBA00023163}.
FT DOMAIN 30..160
FT /note="CG-1"
FT /evidence="ECO:0000259|PROSITE:PS51437"
FT REGION 258..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 366..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..879
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 911..934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..290
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..308
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..482
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..865
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1200 AA; 131349 MW; C836C4F7E6466B3D CRC64;
MNTKDTTEVA ENSHHLKIFL PKKLLECLPR CPLLPPERLR WNTNEEIASY LITFEKHDEW
LSCAPKTRPQ NGSIILYNRK KVKYRKDGYL WKKRKDGKTT REDHMKLKVQ GMEPVSWQCL
YGCYVHSSIV PTFHRRCYWL LQNPDIVLVH YLNVPALEDC GKGCSPIFCS ISSDRREWLK
WSREELLGQL KPMFHGIKWS CGNGTEEFSV EHLVQQILDT HPTKPAPRTH ACLCSGGLGS
GSLTHKCSST KHRIISPKVE PRALTLTSIP HPHPPEPPPL IAPLPPELPK AHTSPSSSSS
SSSSGFAEPL EIRPSPPTSR GGSSRGGTAI LLLTGLEQRA GGLTPTRHLA PQADPRPSMS
LAVVVGTEPS APPAPPSPAF DPDRFLNSPQ RGQTYGGGQG VSPDFPEAEA AHTPCSALEP
AAALEPQAAA RGPPPQSVAG GRRGNCFFIQ DDDSGEELKG QGAAPPIPSP PPSPPPSPVP
LEPSSRVGRG EALFGGPVGA SELEPFSLSS FPDLMGELIS DEAPSIPAPT PQLSPALSTI
TDFSPEWSYP EGGVKVLITG PWTEAAEHYS CVFDHIAVPA SLVQPGVLRC YCPAHEVGLV
SLQVAGREGP LSASVLFEYR ARRFLSLPST QLDWLSLDDN QFRMSILERL EQMEKRMAEI
AAAGQVPCQG PDTPPVQDEG QGPGFEARVV VLVESMIPRS TWKGPERLAH GSPFRGMSLL
HLAAAQGYAR LIETLSQWRS VETGSLDLEQ EVDPLNVDHF SCTPLMWACA LGHLEAAVLL
FRWNRQALSI PDSLGRLPLS VAHSRGHVRL ARCLEELQRQ EASVEPPFAL SPPSSSPDTG
LSSVSSPSEL SDGTFSVTSA YSSAPDGSPP PAPLPASEMT MEDMAPGQLS SGVPEAPLLL
MDYEATNSKG PLSSLPALPP ASDDGAAPEN ADSPQAVDVI PVDMISLAKQ IIEATPERIK
REDFVGLPEA GASMRERTGA VGLSETMSWL ASYLENVDHF PSSTPPSELP FERGRLAVPS
APSWAEFLSA STSGKMESDF ALLTLSDHEQ RELYEAARVI QTAFRKYKGR RLKEQQEVAA
AVIQRCYRKY KQFALYKKMT QAAILIQSKF RSYYEQKRFQ QSRRAAVLIQ QHYRSYRRRP
GPPHRTSATL PARNKGSFLT KKQDQAARKI MRFLRRCRHR MRELKQNQEL EGLPQPGLAT
//
