ID G3RSA6_GORGO Unreviewed; 279 AA.
AC G3RSA6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Sodium/potassium-transporting ATPase subunit beta {ECO:0000256|RuleBase:RU362099};
GN Name=ATP1B3 {ECO:0000313|Ensembl:ENSGGOP00000018681.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000018681.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000018681.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000018681.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000018681.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: This is the non-catalytic component of the active enzyme,
CC which catalyzes the hydrolysis of ATP coupled with the exchange of
CC Na(+) and K(+) ions across the plasma membrane. The exact function of
CC the beta-3 subunit is not known. {ECO:0000256|ARBA:ARBA00037667}.
CC -!- SUBUNIT: The sodium/potassium-transporting ATPase is composed of a
CC catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an
CC additional regulatory subunit. Interacts with catalytic alpha subunit
CC ATP12A. {ECO:0000256|ARBA:ARBA00038625}.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004655}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004655}. Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00037810}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00037810}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the X(+)/potassium ATPases subunit beta family.
CC {ECO:0000256|ARBA:ARBA00005876, ECO:0000256|RuleBase:RU362099}.
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DR EMBL; CABD030024527; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030024528; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018879969.1; XM_019024424.1.
DR AlphaFoldDB; G3RSA6; -.
DR STRING; 9593.ENSGGOP00000018681; -.
DR Ensembl; ENSGGOT00000033539.2; ENSGGOP00000018681.2; ENSGGOG00000027111.2.
DR GeneID; 101140721; -.
DR KEGG; ggo:101140721; -.
DR CTD; 483; -.
DR eggNOG; KOG3927; Eukaryota.
DR GeneTree; ENSGT01030000234579; -.
DR HOGENOM; CLU_057702_1_2_1; -.
DR InParanoid; G3RSA6; -.
DR OMA; WVPEIYN; -.
DR OrthoDB; 2880589at2759; -.
DR TreeFam; TF314618; -.
DR Proteomes; UP000001519; Chromosome 3.
DR Bgee; ENSGGOG00000027111; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005890; C:sodium:potassium-exchanging ATPase complex; IBA:GO_Central.
DR GO; GO:0036126; C:sperm flagellum; IEA:Ensembl.
DR GO; GO:0001671; F:ATPase activator activity; IBA:GO_Central.
DR GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IEA:Ensembl.
DR GO; GO:0030007; P:intracellular potassium ion homeostasis; IBA:GO_Central.
DR GO; GO:0006883; P:intracellular sodium ion homeostasis; IBA:GO_Central.
DR GO; GO:0086009; P:membrane repolarization; IEA:Ensembl.
DR GO; GO:1903288; P:positive regulation of potassium ion import across plasma membrane; IEA:Ensembl.
DR GO; GO:1903278; P:positive regulation of sodium ion export across plasma membrane; IEA:Ensembl.
DR GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
DR GO; GO:0036376; P:sodium ion export across plasma membrane; IBA:GO_Central.
DR Gene3D; 2.60.40.1660; Na, k-atpase alpha subunit; 1.
DR InterPro; IPR000402; Na/K_ATPase_sub_beta.
DR InterPro; IPR038702; Na/K_ATPase_sub_beta_sf.
DR NCBIfam; TIGR01107; Na_K_ATPase_bet; 1.
DR PANTHER; PTHR11523; SODIUM/POTASSIUM-DEPENDENT ATPASE BETA SUBUNIT; 1.
DR PANTHER; PTHR11523:SF47; SODIUM_POTASSIUM-TRANSPORTING ATPASE SUBUNIT BETA-3; 1.
DR Pfam; PF00287; Na_K-ATPase; 1.
DR PROSITE; PS00390; ATPASE_NA_K_BETA_1; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|RuleBase:RU362099};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362099};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362099};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362099}; Transport {ECO:0000256|RuleBase:RU362099}.
FT TRANSMEM 38..62
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362099"
SQ SEQUENCE 279 AA; 31501 MW; 7A1C6961055A5FA0 CRC64;
MTKNEEKSLN QSLAEWKLFT YNPTTGEFLG RTAKSWGLIL LFYLVFYGFL AALFSFTMWV
MLQTLNDEVP KYRDQIPSPG LMVFPKPVTA LEYTFSRSDP TSYAGYIEDL KKFLKPYTLE
EQKNLTVCPD GALFEQKGPV YVACQFPISL LQACSGMNDP DFGYSQGNPC ILVKMNRIIG
LKPEGVPRID CVSKNEDIPN VAVYPHNGMI DLKYFPYYGK KLHVGYLQPL VAVQVSFAPN
NTGKEVTVEC KIDGSANLKS QDDRDKFLGR VMFKITARA
//
