ID G3RSW4_GORGO Unreviewed; 760 AA.
AC G3RSW4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Cadherin 13 {ECO:0000313|Ensembl:ENSGGOP00000018889.2};
GN Name=CDH13 {ECO:0000313|Ensembl:ENSGGOP00000018889.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000018889.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000018889.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000018889.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000018889.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030102419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030102420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030102421; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030102422; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030102423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030102424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030102425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030102426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030102427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030102428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004058112.1; XM_004058064.2.
DR AlphaFoldDB; G3RSW4; -.
DR STRING; 9593.ENSGGOP00000018889; -.
DR Ensembl; ENSGGOT00000027868.2; ENSGGOP00000018889.2; ENSGGOG00000012330.3.
DR GeneID; 101134325; -.
DR CTD; 1012; -.
DR GeneTree; ENSGT00940000155218; -.
DR HOGENOM; CLU_005284_5_1_1; -.
DR InParanoid; G3RSW4; -.
DR OMA; QVCICKK; -.
DR OrthoDB; 5306553at2759; -.
DR Proteomes; UP000001519; Chromosome 16.
DR Bgee; ENSGGOG00000012330; Expressed in prefrontal cortex and 5 other cell types or tissues.
DR GO; GO:0005912; C:adherens junction; IBA:GO_Central.
DR GO; GO:0016342; C:catenin complex; IBA:GO_Central.
DR GO; GO:0005901; C:caveola; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0043005; C:neuron projection; IEA:Ensembl.
DR GO; GO:0055100; F:adiponectin binding; IEA:Ensembl.
DR GO; GO:0045296; F:cadherin binding; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0030169; F:low-density lipoprotein particle binding; IEA:Ensembl.
DR GO; GO:0034332; P:adherens junction organization; IBA:GO_Central.
DR GO; GO:0016339; P:calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
DR GO; GO:0000902; P:cell morphogenesis; IBA:GO_Central.
DR GO; GO:0044331; P:cell-cell adhesion mediated by cadherin; IBA:GO_Central.
DR GO; GO:0007043; P:cell-cell junction assembly; IBA:GO_Central.
DR GO; GO:0043542; P:endothelial cell migration; IEA:Ensembl.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IBA:GO_Central.
DR GO; GO:0043616; P:keratinocyte proliferation; IEA:Ensembl.
DR GO; GO:0030032; P:lamellipodium assembly; IEA:Ensembl.
DR GO; GO:0051668; P:localization within membrane; IEA:Ensembl.
DR GO; GO:0055096; P:low-density lipoprotein particle mediated signaling; IEA:Ensembl.
DR GO; GO:0007162; P:negative regulation of cell adhesion; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0050850; P:positive regulation of calcium-mediated signaling; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0001954; P:positive regulation of cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0050927; P:positive regulation of positive chemotaxis; IEA:Ensembl.
DR GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0016601; P:Rac protein signal transduction; IEA:Ensembl.
DR GO; GO:0030100; P:regulation of endocytosis; IEA:Ensembl.
DR GO; GO:0042058; P:regulation of epidermal growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:Ensembl.
DR GO; GO:0002040; P:sprouting angiogenesis; IBA:GO_Central.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR014868; Cadherin_pro_dom.
DR PANTHER; PTHR24027:SF80; CADHERIN-13; 1.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08758; Cadherin_pro; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SMART; SM01055; Cadherin_pro; 1.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 194..292
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 293..410
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 411..524
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 525..632
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 631..749
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 37..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 760 AA; 83362 MW; 02BDD80523F6CE05 CRC64;
MKTPPGASSR TKCSRELRSF CAFSCPRAKQ PTCTAWFPQQ ENPSENGPQM PGRGSPAAST
MQVLLLTSAE DLDCTPGFQQ KVFHINQPAE FIEDQSILNL TFSDCKGNDK LRYEVSSPYF
KVNSDGGLVA LRNITAVGKT LFVHARTPHA EDMAELVIVG GKDIQGSLQD IFKFARTSPV
PRQKRSIVVS PILIPENQRQ PFPRDVGKVV DSDRPERSKF RLTGKGVDQE PKGIFRINEN
TGSVSVTRTL DREVIAVYQL FVETTDVNGK TLEGPVPLEV IVIDQNDNRP IFREGPYVGH
VMEGSPTGTT VMRMTAFDAD DPATDNALLR YNIRQQTPDK PSPNMFYIDP EKGDIVTVVS
PALLDRETLE NPKYELIIEA QDMAGLDVGL TGTATATIMI DDKNDHSPKF TKKEFQATVK
EGAVGVIVNL TVEDKDDPTT GAWRAAYTII NGNPGQSFEI HTNPQTNEGM LSVVKPLDYE
ISAFHTLLIK VENEDPLVPD VSYGPSSTAT VHITVLDVNE GPVFYPDPMM VTRQEDISVG
SVLLTVNATD PDSLQHQTIR YSVYKDPAGW LNINPINGTV DTTAVLDRES PFVDNSVYTA
LFLAIDSGNP PATGTGTLLI TLEDVNDNAP FIYPTVAEVC DDAKNLSVVI LGASDKDLHP
NTDPFKFEIH KQAVPDKVWK ISKINNTHAL VSLLQNLNKA NYNLPIMVTD SGKPPMTNIT
DLRVQVCSCR NSKVDCNTAG ALRFNLPSLL LLSLFSLACL
//
