ID G3RUA2_GORGO Unreviewed; 966 AA.
AC G3RUA2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Myocardin related transcription factor A {ECO:0000313|Ensembl:ENSGGOP00000019379.2};
GN Name=MRTFA {ECO:0000313|Ensembl:ENSGGOP00000019379.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000019379.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000019379.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000019379.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000019379.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030121223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030121224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030121225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030121226; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030121227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030121228; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030121229; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018873983.1; XM_019018438.1.
DR AlphaFoldDB; G3RUA2; -.
DR STRING; 9593.ENSGGOP00000019379; -.
DR Ensembl; ENSGGOT00000025637.2; ENSGGOP00000019379.2; ENSGGOG00000015180.3.
DR GeneID; 101146760; -.
DR CTD; 57591; -.
DR GeneTree; ENSGT00950000182979; -.
DR InParanoid; G3RUA2; -.
DR OMA; SQPPCQL; -.
DR OrthoDB; 2997330at2759; -.
DR Proteomes; UP000001519; Chromosome 22.
DR Bgee; ENSGGOG00000015180; Expressed in prefrontal cortex and 5 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0051145; P:smooth muscle cell differentiation; IBA:GO_Central.
DR Gene3D; 6.10.140.2040; -; 1.
DR Gene3D; 6.10.150.10; -; 1.
DR Gene3D; 1.10.720.30; SAP domain; 1.
DR InterPro; IPR043451; Myocardin-like.
DR InterPro; IPR004018; RPEL_repeat.
DR InterPro; IPR003034; SAP_dom.
DR InterPro; IPR036361; SAP_dom_sf.
DR PANTHER; PTHR22793:SF6; MYOCARDIN-RELATED TRANSCRIPTION FACTOR A; 1.
DR PANTHER; PTHR22793; MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED; 1.
DR Pfam; PF02755; RPEL; 3.
DR Pfam; PF02037; SAP; 1.
DR SMART; SM00707; RPEL; 3.
DR SMART; SM00513; SAP; 1.
DR SUPFAM; SSF68906; SAP domain; 1.
DR PROSITE; PS51073; RPEL; 3.
DR PROSITE; PS50800; SAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT REPEAT 15..40
FT /note="RPEL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00401"
FT REPEAT 59..84
FT /note="RPEL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00401"
FT REPEAT 103..128
FT /note="RPEL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00401"
FT DOMAIN 382..416
FT /note="SAP"
FT /evidence="ECO:0000259|PROSITE:PS50800"
FT REGION 145..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 593..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 709..781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 798..851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..227
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..252
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 340..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..624
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 709..725
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 767..781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..845
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 966 AA; 103128 MW; 1E4DD657B7F36585 CRC64;
MTLLEPEMLM MAVQSVLQLK LQQRRTREEL VSQGIMPPLK SPAAFHEQRR SLERARTEDY
LKRKIRSRPE RSELVRMHIL EETSAEPSLQ AKQLKLKRAR LADDLNEKIA QRPGPMELVE
KNILPVESSL KEAIIVGQVN YPKVADSSSF DEDSSDALSP EQPASHESQG SVPSPLEARV
SEPLPSATSA SPTQVVSQLP MGRDSREMLF LAEQPPLPPP PLLPPSLTNG TTVPTAKSTP
TLIKQSQPKS ASEKSQRSKK AKELKPKVKK LKYHQYIPPD QKQDRGAPPM DSSYAKILQQ
QQLFLQLQIL NQQQQQHHNY QAILPAPPKS AGEALGSSGT PPVRSLSTTN SSSSSGAPGP
CGLARQNSTS LTGKPGALPA NLDDMKVAEL KQELKLRSLP VSGTKTELIE RLRAYQDQIS
PVPGAPKAPA TTSILHKAGE VVVAFPAARL STGPALVAAG LAPTEVVVAT VTSNGVVKFG
STGSTPPVSP TPSERSLLST GDENSTPGDT FGEMVTSPLT QLTLQASPLQ ILVKEEGPRA
GSCCLSPGGR AELEGRDKDQ MLQEKDKQIE ALTRMLRQKQ QLVERLKLQL EQEKRAQQPA
PAPAPLGTPV KQENSFSSCQ LSRQPLGPAH PFNPSLAAPA TNHIDPCAVA PGPPSVVVKQ
EALQPEPEPV PAPQLLLGPQ GPGLIKGIAP PTLITDSTGT HLVLTVTNKN ADSPGLSSGS
PQQPSSQPGS PAPAPSAQMD LEHPLQPLFG TPTSLLKKEP PGYEEAMNQQ PKQQENGSSS
QQMDDLFDIL IQSGEISADF KEPPSLPGKE KPSPKTVCGS PLAAQPSPSA ELPQAAPPPP
GSPSLPGRLE DFLESSTGLP LLTSGHDGPE PLSLIDDLHS QMLSSTAILD HPPSPMDTSE
LHFVPEPSST MGLDLADGHL DSMDWLELSS GGPVLSLAPL STTAPSLFST DFLDGHDLQL
HWDSCL
//
