ID G3RWZ7_GORGO Unreviewed; 519 AA.
AC G3RWZ7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Spermatogenesis-defective protein 39 homolog {ECO:0000256|ARBA:ARBA00019368};
DE AltName: Full=VPS33B-interacting protein in apical-basolateral polarity regulator {ECO:0000256|ARBA:ARBA00029984};
DE AltName: Full=VPS33B-interacting protein in polarity and apical restriction {ECO:0000256|ARBA:ARBA00031270};
GN Name=VIPAS39 {ECO:0000313|Ensembl:ENSGGOP00000020332.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000020332.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000020332.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000020332.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000020332.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|ARBA:ARBA00004412}.
CC Endosome {ECO:0000256|ARBA:ARBA00004177}.
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DR EMBL; CABD030093342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3RWZ7; -.
DR STRING; 9593.ENSGGOP00000020332; -.
DR Ensembl; ENSGGOT00000023723.2; ENSGGOP00000020332.2; ENSGGOG00000016527.3.
DR GeneTree; ENSGT00390000013955; -.
DR HOGENOM; CLU_029487_0_0_1; -.
DR InParanoid; G3RWZ7; -.
DR OMA; YWNRSSR; -.
DR Proteomes; UP000001519; Chromosome 14.
DR Bgee; ENSGGOG00000016527; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
DR GO; GO:0099023; C:vesicle tethering complex; IEA:Ensembl.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR GO; GO:0030199; P:collagen fibril organization; IEA:Ensembl.
DR GO; GO:0032963; P:collagen metabolic process; IEA:Ensembl.
DR GO; GO:0008333; P:endosome to lysosome transport; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0043687; P:post-translational protein modification; IEA:Ensembl.
DR GO; GO:0007034; P:vacuolar transport; IBA:GO_Central.
DR InterPro; IPR040057; Spe-39.
DR InterPro; IPR006925; Vps16_C.
DR PANTHER; PTHR13364; DEFECTIVE SPERMATOGENESIS PROTEIN 39; 1.
DR PANTHER; PTHR13364:SF6; SPERMATOGENESIS-DEFECTIVE PROTEIN 39 HOMOLOG; 1.
DR Pfam; PF04840; Vps16_C; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 203..304
FT /note="Vps16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF04840"
FT REGION 96..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 519 AA; 59688 MW; 6A96FF06D57D8E23 CRC64;
TTTGLIVFFQ SGRPLGAGVR LGLGLRMNRT KGDEEEYWNS SKFKAFTFDD EDDELSQLKE
SKRAVNSLRD FVDDDDDDDL ERVSWSGEPV GSISWSIRET AGNSGSTHEG REQLKSRNSF
SSYAQLPKPT STYSLSSFFR GRTRPGSFQS LSDALSDTPA KSYAPELGRP KGEYRDYSND
WSPSDTVRRL RKGKVCSLER FRSLQDKLQL LEEAVSMHDG NVITAVLIFL KRTLSKEILF
RELEVRQVAL RHLIHFLKEI GDQKLLLDLF RFLDRTEELA LSHYREHLNI QDPDKRKEFL
KTCVGLPFSA EDSAHIQDHY TLLERQIIIE ANDRHLESAG QTEIFRKHPR KASILNMPLV
TTLFYSCFYH YTEAEGTFSS PINLKKTFKI PDKQYVLTAL AARAKLRAWN DVDALFTTKN
WLGYTKKRAP IGFHRVVEIL HKNNAPVQIL QEYVNLVEDV DTKLNLATKF KCHDVVIDTY
RDLKDRQQLL AYRSKVDKGS AEEEKIDALL SSSQIRWKN
//
