ID G3S0M1_GORGO Unreviewed; 1045 AA.
AC G3S0M1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 69.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=FBH1 {ECO:0000313|Ensembl:ENSGGOP00000021616.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000021616.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000021616.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000021616.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000021616.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CABD030067764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018890364.1; XM_019034819.1.
DR AlphaFoldDB; G3S0M1; -.
DR Ensembl; ENSGGOT00000028329.2; ENSGGOP00000021616.2; ENSGGOG00000013326.3.
DR GeneID; 101129472; -.
DR CTD; 84893; -.
DR eggNOG; KOG2108; Eukaryota.
DR GeneTree; ENSGT00390000011669; -.
DR OrthoDB; 5490899at2759; -.
DR TreeFam; TF329020; -.
DR Proteomes; UP000001519; Chromosome 10.
DR Bgee; ENSGGOG00000013326; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd22095; F-box_FBXO18; 1.
DR CDD; cd18786; SF1_C; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF30; F-BOX DNA HELICASE 1; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 211..260
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REGION 30..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 71..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..176
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1045 AA; 118105 MW; 8436806DECBAB3EA CRC64;
MRRFKRKHLT AIDCQHLARS HLAVTQPFGQ RWTNRDPNHG LYPKPRTKRG SRGQGRQRCI
PEFFLAGKRP CTNDMAKSNS VGQDSCQDSE GNMIFPAESS CALPQEGSGE AGLGSSGSAP
PSRKRSWSSE EESNQATGTS RWDGVSKKAP RHHLSVPCTR PREARQEAED SMSRLSAESG
ETDQDAGDMG PDLIPDSYYG LLGTLPCQEA LSHICSLPSE VLRHVFAFLP VEDLYWNLSL
VCHLWREIIS DPLFIPWKKL YHRYLMNEEQ AVSKVDGILS NCGIEKESDL CVLNLIRYTA
TTKCSPSVDP ERVLWSLRDH PLLPEAEACV RQHLPDLYAA AGGVNIWALV AAVVLLSSSV
NDIQRLLFCL RRPSSTVTMP DVTETLYCIA VLLYAMREKG INISNRIHYN IFYCLYLQEN
SCTQATKVKE EPSVWPGKKT IQLTHEQQLI LNHKMEPLQV VKIMAFAGTG KTSTLVKYAE
KWSQSRFLYV TFNKSIAKQA ERVFPSNVIC KTFHSMAYGH IGRKYQSKKK LNLFKLTPFM
VNSVLAEGKG GFIRAKLVCK TLENFFASAD EELTIDHVPI WCKNSQGQRV MVEQSEKLNG
VLEASRLWDN MRKLGECTEE AYQMTHDGYL KLWQLSKPLL ASFDAIFVDE AQDCTPAIMN
IVLSQPCGKI FVGDPHQQIY TFRGAVNALF TVPHTHVFYL TQSFRFGVEI AYVGATILDV
CKRVRKKTLV GGNHQSGIRG DAKGQVALLS RTNANVFDEA VRVTEGEFPS RIHLIGGIKS
FGLDRIIDIW ILLQPEEERR KQNLVIKDKF IRRWVHKEGF SGFKRYVTAA EDKELEAKIA
VVEKYNIRIP ELVQRIEKCH IEDLDFAEYI LGTVHKAKGL EFDTVHVLDD FVKVPCARHN
LPQLPHFRVE SFSEDEWNLL YVAVTRAKKR LIMTKSLENI LTLAGEYFLQ AELTSNVLKT
GVVRCCVGQC NNAIPVDTVL TMKKLPITYS NRKENKGGYL CHSCAEQRIG PLAFLTASPE
QVRAMERTVE NIVLPRHEAL LFLVF
//