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Database: UniProt
Entry: G3S0M1_GORGO
LinkDB: G3S0M1_GORGO
Original site: G3S0M1_GORGO 
ID   G3S0M1_GORGO            Unreviewed;      1045 AA.
AC   G3S0M1;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   24-JAN-2024, entry version 69.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   Name=FBH1 {ECO:0000313|Ensembl:ENSGGOP00000021616.2};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000021616.2, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000021616.2, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000021616.2, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22398555; DOI=10.1038/nature10842;
RA   Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA   Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA   McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA   Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA   Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA   Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA   Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA   Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA   Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA   Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA   Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA   Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA   Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT   "Insights into hominid evolution from the gorilla genome sequence.";
RL   Nature 483:169-175(2012).
RN   [3] {ECO:0000313|Ensembl:ENSGGOP00000021616.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; CABD030067764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_018890364.1; XM_019034819.1.
DR   AlphaFoldDB; G3S0M1; -.
DR   Ensembl; ENSGGOT00000028329.2; ENSGGOP00000021616.2; ENSGGOG00000013326.3.
DR   GeneID; 101129472; -.
DR   CTD; 84893; -.
DR   eggNOG; KOG2108; Eukaryota.
DR   GeneTree; ENSGT00390000011669; -.
DR   OrthoDB; 5490899at2759; -.
DR   TreeFam; TF329020; -.
DR   Proteomes; UP000001519; Chromosome 10.
DR   Bgee; ENSGGOG00000013326; Expressed in heart and 6 other cell types or tissues.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd22095; F-box_FBXO18; 1.
DR   CDD; cd18786; SF1_C; 1.
DR   Gene3D; 1.20.1280.50; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF30; F-BOX DNA HELICASE 1; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF81383; F-box domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT   DOMAIN          211..260
FT                   /note="F-box"
FT                   /evidence="ECO:0000259|PROSITE:PS50181"
FT   REGION          30..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          71..190
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..94
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        145..176
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1045 AA;  118105 MW;  8436806DECBAB3EA CRC64;
     MRRFKRKHLT AIDCQHLARS HLAVTQPFGQ RWTNRDPNHG LYPKPRTKRG SRGQGRQRCI
     PEFFLAGKRP CTNDMAKSNS VGQDSCQDSE GNMIFPAESS CALPQEGSGE AGLGSSGSAP
     PSRKRSWSSE EESNQATGTS RWDGVSKKAP RHHLSVPCTR PREARQEAED SMSRLSAESG
     ETDQDAGDMG PDLIPDSYYG LLGTLPCQEA LSHICSLPSE VLRHVFAFLP VEDLYWNLSL
     VCHLWREIIS DPLFIPWKKL YHRYLMNEEQ AVSKVDGILS NCGIEKESDL CVLNLIRYTA
     TTKCSPSVDP ERVLWSLRDH PLLPEAEACV RQHLPDLYAA AGGVNIWALV AAVVLLSSSV
     NDIQRLLFCL RRPSSTVTMP DVTETLYCIA VLLYAMREKG INISNRIHYN IFYCLYLQEN
     SCTQATKVKE EPSVWPGKKT IQLTHEQQLI LNHKMEPLQV VKIMAFAGTG KTSTLVKYAE
     KWSQSRFLYV TFNKSIAKQA ERVFPSNVIC KTFHSMAYGH IGRKYQSKKK LNLFKLTPFM
     VNSVLAEGKG GFIRAKLVCK TLENFFASAD EELTIDHVPI WCKNSQGQRV MVEQSEKLNG
     VLEASRLWDN MRKLGECTEE AYQMTHDGYL KLWQLSKPLL ASFDAIFVDE AQDCTPAIMN
     IVLSQPCGKI FVGDPHQQIY TFRGAVNALF TVPHTHVFYL TQSFRFGVEI AYVGATILDV
     CKRVRKKTLV GGNHQSGIRG DAKGQVALLS RTNANVFDEA VRVTEGEFPS RIHLIGGIKS
     FGLDRIIDIW ILLQPEEERR KQNLVIKDKF IRRWVHKEGF SGFKRYVTAA EDKELEAKIA
     VVEKYNIRIP ELVQRIEKCH IEDLDFAEYI LGTVHKAKGL EFDTVHVLDD FVKVPCARHN
     LPQLPHFRVE SFSEDEWNLL YVAVTRAKKR LIMTKSLENI LTLAGEYFLQ AELTSNVLKT
     GVVRCCVGQC NNAIPVDTVL TMKKLPITYS NRKENKGGYL CHSCAEQRIG PLAFLTASPE
     QVRAMERTVE NIVLPRHEAL LFLVF
//
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