ID G3S1F8_GORGO Unreviewed; 1485 AA.
AC G3S1F8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Adhesion G protein-coupled receptor L1 {ECO:0000313|Ensembl:ENSGGOP00000021904.2};
GN Name=ADGRL1 {ECO:0000313|Ensembl:ENSGGOP00000021904.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000021904.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000021904.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000021904.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000021904.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CABD030111922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030111923; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030111924; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030111925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSGGOT00000023748.2; ENSGGOP00000021904.2; ENSGGOG00000015214.3.
DR GeneTree; ENSGT00940000159684; -.
DR HOGENOM; CLU_002753_1_1_1; -.
DR Proteomes; UP000001519; Chromosome 19.
DR Bgee; ENSGGOG00000015214; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd16007; 7tmB2_Latrophilin-1; 1.
DR CDD; cd22844; Gal_Rha_Lectin_LPHN1; 1.
DR Gene3D; 1.25.40.610; -; 1.
DR Gene3D; 2.60.120.740; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 4.10.1240.10; GPCR, family 2, extracellular hormone receptor domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR032471; GAIN_dom_N.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR003924; GPCR_2_latrophilin.
DR InterPro; IPR003334; GPCR_2_latrophilin_rcpt_C.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR031234; Latrophilin-1_TM.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR InterPro; IPR003112; Olfac-like_dom.
DR PANTHER; PTHR12011:SF62; ADHESION G PROTEIN-COUPLED RECEPTOR L1; 1.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF16489; GAIN; 1.
DR Pfam; PF02140; Gal_Lectin; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF02793; HRM; 1.
DR Pfam; PF02354; Latrophilin; 1.
DR Pfam; PF02191; OLF; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01444; LATROPHILIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00008; HormR; 1.
DR SMART; SM00284; OLF; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51132; OLF; 1.
DR PROSITE; PS50228; SUEL_LECTIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00446};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 861..888
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 900..917
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 932..956
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 968..987
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1007..1030
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1051..1074
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1080..1103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..130
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT DOMAIN 142..401
FT /note="Olfactomedin-like"
FT /evidence="ECO:0000259|PROSITE:PS51132"
FT DOMAIN 480..539
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 863..1104
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 403..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1259..1284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1305..1339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1371..1439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1462..1485
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1312..1326
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1371..1389
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1415..1435
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 143..325
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00446"
SQ SEQUENCE 1485 AA; 163755 MW; A8FCB1EB49DE93A2 CRC64;
MVAWAWVLCL EPEVGVTPSP TLPAGLSRAG LPFGLMRREL ACEGYPIELR CPGSDVIMVE
NANYGRTDDK ICDADPFQME NVQCYLPDAF KIMSQRCNNR TQCVVVAGSD AFPDPCPGTY
KYLEVQYDCV PYKVEQKGKL FVCPGTLQKV LEPTSTHESE HQSGAWCKDP LQAGDRIYVM
PWIPYRTDTL TEYASWEDYV AARHTTTYRL PNRVDGTGFV VYDGAVFYNK ERTRNIVKYD
LRTRIKSGET VINTANYHDT SPYRWGGKTD IDLAVDENGL WVIYATEGNN GRLVVSQLNP
YTLRFEGTWE TGYDKRSASN AFMVCGVLYV LRSVYVDDDS EAAGNRVDYA FNTNANREEP
VSLTFPNPYQ FISSVDYNPR DNQLYVWNNY FVVRYSLEFG PPDPSAGPAT SPPLSTTTTA
RPTPLTSTAS PAATTPLRRA PLTTHPVGAI NQLGPDLPPA TAPVPSTRRP PAPNLHVSPE
LFCEPREVRR VQWPATQQGM LVERPCPKGT RGIASFQCLP ALGLWNPRGP DLSNCTSPWV
NQVAQKIKSG ENAANIASEL ARHTRGSIYA GDVSSSVKLM EQLLDILDAQ LQALRPIERE
SAGKNYNKMH KRERTCKDYI KAVVETVDNL LRPEALESWK DMNATEQVHT ATMLLDVLEE
GAFLLADNVR EPARFLAAKE NVVLEVTVLN TEGQVQELVF PQEEYPRKNS IQLSAKTIKQ
NSRNGVVKVV FILYNNLGLF LSTENATVKL AGEAGPGGPG GASLVVNSQV IAASINKESS
RVFLMDPVIF TVAHLEDKNH FNANCSFWNY SERSMLGYWS TQGCRLVESN KTHTTCACSH
LTNFAVLMAH REIYQGRINE LLLSVITWVG IVISLVCLAI CISTFCFLRG LQTDRNTIHK
NLCINLFLAE LLFLVGIDKT QYEIACPIFA GLLHYFFLAA FSWLCLEGVH LYLLLVEVFE
SEYSRTKYYY LGGYCFPALV VGIAAAIDYR SYGTEKACWL RVDNYFIWSF IGPVSFVIVV
NLVFLMVTLH KMIRSSSVLK PDSSRLDNIK SWALGAIALL FLLGLTWAFG LLFINKESVV
MAYLFTTFNA FQGVFIFVFH CALQKKVHKE YSKCLRHSYC CIRSPPGGTH GSLKTSAMRS
NTRYYTGTQV SVAWPRRQRV GGPRIPSHLG NRRSPPSWRV TSTVRRHPSA SGFSTMGNHL
LTNPVLQPRG GTSPYNTLIA ESVGFNPSSP PVFNSPGEKH PLGGREACGM DTLPLNGNFN
NSYSLRSGDF PPGDGGPEPP RGRNLADAAA FEKMIISELV HNNLRGSSSA AKGPPPPEPP
VPPVPGGGGE EEAGGPGGAD RAEIELLYKA LEEPLLLPRA QSVLYQSDLD ESESCTAEDG
ATSRPLSSPP GRDSLYASGA NLRDSPSYPD SSPEGPSEAL PPPPPAPPGP PEIYYTSRPP
ALVARNPLQG YYQVRRPSHE GYLAAPGLEG PGPDGDGQMQ LVTSL
//
