ID G3S2M3_GORGO Unreviewed; 325 AA.
AC G3S2M3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Class I histocompatibility antigen, Gogo-A*0501 alpha chain-like precursor {ECO:0000313|Ensembl:ENSGGOP00000022321.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000022321.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000022321.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000022321.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000022321.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the presentation of foreign antigens to the
CC immune system. {ECO:0000256|ARBA:ARBA00002297}.
CC -!- SUBUNIT: Heterodimer of an alpha chain and a beta chain (beta-2-
CC microglobulin). {ECO:0000256|ARBA:ARBA00011817}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the MHC class I family.
CC {ECO:0000256|ARBA:ARBA00006909, ECO:0000256|RuleBase:RU004439}.
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DR EMBL; CABD030044048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044050; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044051; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044052; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044053; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044054; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030044057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3S2M3; -.
DR Ensembl; ENSGGOT00000034483.2; ENSGGOP00000022321.2; ENSGGOG00000005772.3.
DR GeneTree; ENSGT00980000198488; -.
DR Proteomes; UP000001519; Chromosome 6.
DR Bgee; ENSGGOG00000005772; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IEA:UniProt.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProt.
DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProt.
DR GO; GO:0098553; C:lumenal side of endoplasmic reticulum membrane; IEA:UniProt.
DR GO; GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProt.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProt.
DR GO; GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd21027; IgC1_MHC_Ia_HLA-A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR001039; MHC_I_a_a1/a2.
DR InterPro; IPR010579; MHC_I_a_C.
DR PANTHER; PTHR16675:SF229; HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A ALPHA CHAIN; 1.
DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR Pfam; PF06623; MHC_I_C; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW MHC I {ECO:0000256|ARBA:ARBA00022451};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..325
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014168739"
FT DOMAIN 209..295
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 325 AA; 36932 MW; A46399DE9F2C6160 CRC64;
MAVVAPRTLL LLLSGALALT QTWAGSHSMR YFSTSVSRPG RGEPRFIAVG YVDDTQFVRF
DSDAASQRME PRAPWMEQEE PEYWDRQTQI SKTNAQIELE SLRIALRYYN QSEDGSHTIQ
RMYGCDVGSD GRFLRGYQQD AYDGKDYIAS NEDLRSWTAA DMAAEITKRK WEAAHFAEQL
RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHPVSD HEAILRCWAL SFYPAEITLT
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWDR
KGGSYSQAAS SDSAQGSDVS LTACK
//
