ID G3S2N2_GORGO Unreviewed; 3476 AA.
AC G3S2N2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Abnormal spindle-like microcephaly-associated protein {ECO:0000313|Ensembl:ENSGGOP00000022330.2};
GN Name=ASPM {ECO:0000313|Ensembl:ENSGGOP00000022330.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000022330.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000022330.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000022330.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000022330.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CABD030008134; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008135; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030008137; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018878054.1; XM_019022509.1.
DR Ensembl; ENSGGOT00000027235.2; ENSGGOP00000024559.2; ENSGGOG00000025635.2.
DR Ensembl; ENSGGOT00000033391.2; ENSGGOP00000022330.2; ENSGGOG00000025635.2.
DR GeneID; 101132110; -.
DR CTD; 259266; -.
DR GeneTree; ENSGT00560000077332; -.
DR OMA; CCCCYIF; -.
DR OrthoDB; 53079at2759; -.
DR TreeFam; TF351180; -.
DR Proteomes; UP000001519; Chromosome 1.
DR Bgee; ENSGGOG00000025635; Expressed in testis.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0072687; C:meiotic spindle; IEA:Ensembl.
DR GO; GO:0036449; C:microtubule minus-end; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0097431; C:mitotic spindle pole; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000922; C:spindle pole; IBA:GO_Central.
DR GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR GO; GO:0008356; P:asymmetric cell division; IEA:Ensembl.
DR GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
DR GO; GO:0048589; P:developmental growth; IEA:Ensembl.
DR GO; GO:0051295; P:establishment of meiotic spindle localization; IBA:GO_Central.
DR GO; GO:0021873; P:forebrain neuroblast division; IEA:Ensembl.
DR GO; GO:0051661; P:maintenance of centrosome location; IEA:Ensembl.
DR GO; GO:0008584; P:male gonad development; IEA:Ensembl.
DR GO; GO:0090306; P:meiotic spindle assembly; IEA:Ensembl.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0045769; P:negative regulation of asymmetric cell division; IEA:Ensembl.
DR GO; GO:0045665; P:negative regulation of neuron differentiation; IEA:Ensembl.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:0097150; P:neuronal stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0048477; P:oogenesis; IEA:Ensembl.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0051445; P:regulation of meiotic cell cycle; IEA:Ensembl.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR GO; GO:0007051; P:spindle organization; IBA:GO_Central.
DR CDD; cd21223; CH_ASPM_rpt1; 1.
DR CDD; cd21224; CH_ASPM_rpt2; 1.
DR Gene3D; 1.20.5.190; -; 32.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22706:SF1; ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ISOFORM X1; 1.
DR PANTHER; PTHR22706; UNCHARACTERIZED; 1.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 38.
DR SMART; SM00033; CH; 2.
DR SMART; SM00015; IQ; 62.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 19.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50096; IQ; 40.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 919..1055
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1109..1260
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 416..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3476 AA; 409591 MW; C7FF21572D0C0E31 CRC64;
MANRRVGRGC WEVSPTERRP PAGLRGPAAE EEASSPPVLS LSHFCRSPFL CFGDVLLGAS
RTLSLALDNP NEEVAEVKIS HFPAADLGFS VSQRCFVLQP KEKIVISVNW TPLKEGRVRE
IMTFLVNDVL KHQAILLGNA EEQKKKKRSL WDTIKKKKIS ASTSHNRRVS NIQNVNKTFS
VSQKVDRVRS PLQACENLAM NEGGPPTENN SLTLEENKIP ISPISPAFNE CHGATCLPLS
VRRSTTYSSL HASENRELLN VHSANVSKVS FNEKAVTETS FNSVNVNGQS GENSKLSLTP
NYSSTLNITQ SQIHFLSPDS FVNNSHGANN ELELVTCLSS DMFMKDNSKP VHLESTIAHE
IYQKILSPDS FIKDNYGLNQ DLESESVNPI LSPNQFLKDN MAYVCTSQQT CKVPLSNENS
QVPQSPEDWR KSEVSPRIPE CQGSKSPKAI FEEIVEMKSN YYSFIKQNNP KFSAVQDISS
HSHNKQPKRR PILSATVTKR KATCTRENQT EINKPKAKRC LNSAVGEHEK VINNQKEKDF
HSYLPIIDPI LSKSKSYKNE VAPSSTTASV ARKRKSDGSM EDANVRVAVT EHTEVREIKR
IHFSPSEPKT SAVKKTKNVI TPISKHISNR EKLNLKKKTD LSIFRTPISK TNKRTKPIIA
VAQSNLTFIK PLKTDIPRHP MPFAAKNMFY DERWKEKQEQ GFTWWLNFIL TPDDFTVKTN
ISEVNAATLL LGIENQHKIS VPRAPTKEEM SLRAYTARCR LNRLRRAACR LFTSEKMVKA
IKKLEIEIEA RRLIVRKDRH LWKDVGERQK VLNWLLSYNP LWLRIGLETT YGELISLEDN
SDVTGLAMFI LNRLLWNPDI AAEYRHPTVP HLYRDGHEEA LSKFTLKKLL LLVCFLDYAK
ISRLIDHDPC LFCKDAEFKA SKEILLAFSR DFLSGEGDLS RHLGLLGLPV NHVQTPFDEF
DFAVTNLAVD LQCGVRLVRT MELLTQNWDL SKKLRIPAIS RLQKMHNVDV VLQVLKSRGI
ELSDEHGNTI LSKDIVDRHR EKTLRLLWKI AFAFQVDISL NLDQLKEEIA FLKHTKSIKK
TISLLSCHSD DLINKKKGKR DSGSFEQYSE NIKLLMDWVN AVCAFYNKKV ENFTVSFSDG
RVLCYLIHHY HPCYVPFDAI CQRTTQTVEC TQTGSVVLNS SSESDDSSLD MSLKAFDHEN
TSELYKELLE NEKKNFHLVR SAVRDLGGIP AMINHSDMSN TIPDEKVVIT YLSFLCARLL
DLRKEIRAAR LIQTTWRKYK LKTDLKRHQE REKAARIIQL AVINFLAKQR LRKRVNAALV
IQKYWRRVLA QRKLLMLKKE KLEKVQNKAA SLIQGYWRRY STRRRFLKLK YYSIILQSRI
RMIIAVTSYK RYLWATVTIQ RHWRAYLRRK QDQQRYEMLK SSTLVIQSMF RKWKQRKMQS
QVKATVILQR AFREWHLRKH AKEENSAIII QSWYRMHKEL QKYIYIRSCV VIIQKRFRCF
QAQKLYKRKK ESILTIQKYY KAYLKGKIER TNYLQKRAAA IQLQAAFRRL KAHNLCRQIR
AACVIQSYWR MRQDRVRFLN LKKTIIKLQA HVRKHQQRQK YKKMKKAAVI IQTHFRAYIF
ARKVLASYQK TRSAVIVLQS AYRGMQARKM YVHILTSVIK IQSYYRAHVS KKEFLSLKNA
TIKLQSIVKM KQTRKQYLHL RAAALFIQQC YRSKKIAAQK REEYMQMRES CIKLQAFVRG
YLVRKQMRLQ RKAVISLQSY FRMRKARQYY LKMYKAIIVI QNYYHAYKAQ VNQRKNFLQV
KKAATCLQAA YRGYKVRQLI KQQSIAALKI QSAFRGYNKR VKYQSVLQSI IKIQRWYRAY
KTLHDTRTHF LKTKAALISL QSAYRGWKVR KQIRREHQAV LKIQSAFRMA KAQKQFRLFK
TAALVIQQNF KAWTAGRKQR MEYIELRHAV LMLQSMWRGK TLRRQLQRQH KCAVIIQSYY
RMHVQQKKWK IMKKAALLIQ KYYRAYSIGR EQNHLYLKTK AAVVTLQSAY RGMKVRKRIK
DCNKAAVTIQ SKYRAYKTKK KYATYRASAI IIQRWYRGIK ITNHQHKEYL NLKKTAIKIQ
SVYRGIRVRR HIQHMHRAAT FIKAVFKMHQ SRISYHTMRK AAIVIQVRFR AYYQGKTQRE
KYLTILKAVK ILQASFRGVR VRRTLRKMQI AATLIQSNYR RYRKQTYFNK LKKITKTVQQ
RYRAMKERNI QFQRYNKLRH SVIYIQAIFR GKKARRHLKM MHIAATLIQR RFRTLMMRRR
FLSLKKTAIL IQRKYRAHLC TKHHLQFLQV QNAVIKIQSS YRRWMIRKRM REMHRAATFI
QATFRMHRLH MRYQTLKQAS VVIQQQYQAN RAAKLQRQHY LRQRHSAVIL QAAFRGMKTR
RHLKSMHSSA TLIQSRFRSL LVRRRFISLK KATIFVQRKY RATICAKHKL HQFLHLRKAA
ITIQSSYRRL MVKKKLQEMQ RAAILIQATF RMHRTYTTFQ TWKHASILIQ QHYRTYRAAK
LQRENYIRQW HSAVVIQAAY KGMKARHLLR EKHKASIIIQ STYRMYRQYC FYQKLQWATK
IIQEKYRANK KKQKAFQHNE LKKETCVQAG FQDMNIKKQI QEQHQAAIII QKHCKAFKIR
KHYLHLRATV VSIQRRYRKL TAVRTQAVIC IQSYYRGFKV RKDIQNMHQA ATLIQSFYRM
HRAKVDYETK KTAIVVIQNY YRLYVRVKTE RKNFLAVQKS VRTIQAAFRG MEVRQKLENV
SEEKMAAIVN QSALCCYRSK TQYEAVQSEG VMIQEWYKAS GLACSQEAEY HSQSRAAVTI
QKAFCRMATR KLETQKYAAL RIQFFLQMAV YRRRFVQQKR AAITLQHYFR TWQTRKQFLL
YRKAAVVLQN HYRAFLSAKH QRQVYLQIRS SVIIIQARSK GFIQKRKFQE IKNSTIKIQA
MWRRYRAKKY LCKVKAACKI QAWYRCWRAH KEYLAILKAV KIIQGCFYTK LERTRFLNVR
ASAIIIQRKW RAILSAKIAH EHFLMIKRHR AACLIQAHYR GYKGRQVFLR QKSAALIIQK
YIRAREAGKR ERIKYIEFKK STVILQALVR GWLVRKRILE QRAKIRLLHF TAAAYYHLNA
LRIQRAYKLY LAMKHANKQV NSVICIQRWF RARLQEKRFI QKYHSVKKIE HEGQECLSQR
NRAASVIQKA VRHFLLRKKQ EKFTSGIIKI QALWRGYSWR KKNDCTKIKA IRLSLQVVNR
EIREENKLYK RTALALHYLL TYKHLSAILE ALKHLEVVTR LSPLCCENMA HSGAISKIFV
LIRSCNRSVP CMEVIRYAVQ VLLNVSKYEK TTSAVYDVEN CIDILLELLQ IYREKPGNKV
ADKGGSIFTK TCCLLAILLK TTNRASDVRS RSKVVDRIYS LYKLTAHKHK MNTERILYKQ
KKNSSISIPF IPETPVRTRI VSRLKPDWVL RRDNMEEITN PLQALQMVMD TLGIPY
//
