ID G3S3Q2_GORGO Unreviewed; 808 AA.
AC G3S3Q2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSGGOP00000022702.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000022702.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000022702.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000022702.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000022702.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030065123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030065124; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030065125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030065126; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030065127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3S3Q2; -.
DR STRING; 9593.ENSGGOP00000022702; -.
DR Ensembl; ENSGGOT00000023093.2; ENSGGOP00000022702.2; ENSGGOG00000024707.2.
DR GeneTree; ENSGT00390000004113; -.
DR InParanoid; G3S3Q2; -.
DR OMA; CNERDPV; -.
DR Proteomes; UP000001519; Chromosome 9.
DR Bgee; ENSGGOG00000024707; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14506; PTP_PTPDC1; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR049573; PTPDC1_PTP.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR23339:SF125; PROTEIN TYROSINE PHOSPHATASE DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23339; TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE; 1.
DR Pfam; PF00782; DSPc; 1.
DR SMART; SM00195; DSPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 136..307
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 222..289
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 68..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 541..604
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 568..602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 808 AA; 90271 MW; 404657AC2DE80FF7 CRC64;
MQVQDATRWP SAVHFLSSFL QGRRHSTSDP VLRLQQARRG SGLGSGSATK LLSSSSLKVM
VAVSSVSHAE GNPTFPERKS KGNLERPTPK YTKVGERLRH VIPGHMACSM ACGGRACKYE
NPARWSEQEQ AIKGVYSSWV TDNILAMARP SSELLEKYHI IDQFLSHGIK TIINLQRPGE
HASCGNPLEQ ESGFTYLPEA FMEAGIYFYN FGWKDYGVAS LTTILDMVKV MTFALQEGKV
AIHCHAGLGR TGVLIACYLV FATRMTADQA IIFVRAKRPN SIQTRGQLLC VREFTQFLTP
LRNIFSCCDP KAHAVTLAQY LIRQRHLLHG YEARLLKHVP KIIHLVCKLL LDLAENRPVM
MKDVSEGPGL SAEIEKTMSE MVTMQLDKEL LRHDSDVSNP PNPTAVAADF DNRGMIFSNE
QQFDPLWKRR NVECLQPLTH LKRRLSYSDS DLKRAENLLE QGETPQTVPA QIMVGHKPRQ
QKLISHCYIP QSPEPDLHKE ALVRSTLSFW SQSKFGGLEG LKDNGSPIFH GRIIPKEAQQ
SGAFSADVSG SHSPGEPVSP SFANVHKDPN PAHQQVSHCQ CKTHGVGSPG SVRQNSRIPR
SPLDCGSSPK VQFLVEHETQ DSKDLSEAAS HSALQSELSA EARRILAAKA LANLNESVEK
EELKRKVEMW QKELNSRDGA WERICGERDP FILCSLMWSW VEQLKEPVIT KEDVDMLVNR
RADAAEALFL LEKGQHQTIL CVLHCIVNLQ TIPVDVEEAF LAHAIKAFTK VNFDSENGPT
VYNTLKKIFK HTLEEKRKMA KDGPKPGL
//
