ID G3S427_GORGO Unreviewed; 589 AA.
AC G3S427;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=SH3 domain binding protein 2 {ECO:0000313|Ensembl:ENSGGOP00000022829.2};
GN Name=SH3BP2 {ECO:0000313|Ensembl:ENSGGOP00000022829.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000022829.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000022829.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000022829.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000022829.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030026769; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030026770; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018880725.1; XM_019025180.1.
DR AlphaFoldDB; G3S427; -.
DR Ensembl; ENSGGOT00000032718.2; ENSGGOP00000022829.2; ENSGGOG00000014162.3.
DR GeneID; 101146957; -.
DR CTD; 6452; -.
DR GeneTree; ENSGT00390000002216; -.
DR HOGENOM; CLU_040124_0_0_1; -.
DR OrthoDB; 5473346at2759; -.
DR Proteomes; UP000001519; Chromosome 4.
DR Bgee; ENSGGOG00000014162; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13308; PH_3BP2; 1.
DR CDD; cd10359; SH2_SH3BP2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035848; SH3BP2.
DR InterPro; IPR035847; SH3BP2_SH2.
DR PANTHER; PTHR15126:SF4; SH3 DOMAIN-BINDING PROTEIN 2; 1.
DR PANTHER; PTHR15126; SH3-BINDING; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 54..158
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 485..583
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 188..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..243
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..291
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 406..420
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 589 AA; 65207 MW; 5D9F90EDB890DD67 CRC64;
MASVGPRTPA LSRSRGRRAM CWVSTISFMA AEEMHWPVPM KAIGAQNLLT MPGGVAKAGY
LHKKGGTQLQ LLKWPLRFVI IHKRCVYYFK SSTSASPQGA FSLSGYNRVM RAAEETTSNN
VFPFKIIHVS KKHRTWFFSA SSEDERKSWM ALLRREIGHF HEKKDLPLDT SDSSSDTDSF
YGAVERPVDI SLSPCPTDNE DYEHDDEDDS YLEPDSPEPG RLEDALMHPP AYPPPPVPTP
RKPAFSDMPR AHSFTSKGPG PLLPPPPPKH GLPDVGLAAE DSKRDPLCPR RAEPCPRVPA
TPRRMSDPPL STMPTAPGLR KPPCFRESAS PSPEPWTPGH GACSTSSAAI MATATSRNCD
KLKSFHLSPR GPPTSEPPPV PANKPKFLKT AEEDPPREAA MPGLFVPPVA PRPPALKLPV
PEAMARPAVL PRPEKPQLPH LQRSPPDGQS FRSFSFEKPR QPSQADTGGD DSDEDYEKVP
LPNSVFVNTT ESCEVERLFK ATSPRGEPQD GLYCIRNSST KSGKVLVVWD ETSNKVRNYR
IFEKDSKFYL EGEVLFVSVG SMVEHYHTHV LPSHQSLLLR HPYGYTGPR
//
