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Database: UniProt
Entry: G3S549_GORGO
LinkDB: G3S549_GORGO
Original site: G3S549_GORGO 
ID   G3S549_GORGO            Unreviewed;      2367 AA.
AC   G3S549;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   28-MAR-2018, entry version 37.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1G {ECO:0000313|Ensembl:ENSGGOP00000023204};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000023204, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000023204, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000023204}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR   EMBL; CABD030037222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030037223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSGGOT00000028080; ENSGGOP00000023204; ENSGGOG00000003386.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000001519; Chromosome 5.
DR   Bgee; ENSGGOG00000003386; -.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.120.350; -; 4.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR030154; VDCC_T_a1G.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   PANTHER; PTHR10037:SF137; PTHR10037:SF137; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    127    147       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    162    184       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    205    238       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    364    385       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    734    752       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    764    785       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    855    874       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    931    954       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1267   1285       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1305   1326       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1338   1357       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1402   1424       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1504   1527       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1602   1623       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1635   1658       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1736   1755       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1819   1841       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       86    395       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      733    959       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1265   1537       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1601   1851       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1536   1563       {ECO:0000256|SAM:Coils}.
FT   COILED     1840   1864       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2367 AA;  260902 MW;  57483FC0C3AAED7B CRC64;
     MDEEEDGAGA EESGQPRSFM RLNDLSGAGG RPGPGSAEKD PGSADSEAEG LPYPALAPVV
     FFYLSQDSRP RSWCLRTVCN PYPSGTWFER ISMLVILLNC VTLGMFRPCE DIACDSQRCR
     ILQAFDDFIF AFFAVEMVVK MVALGIFGKK CYLGDTWNRL DFFIVIAGML EYSLDLQNVS
     FSAVRTVRVL RPLRAINRVP SMRILVTLLL DTLPMLGNVL LLCFFVFFIF GIVGVQLWAG
     LLRNRCFLPE NFSLPLSVDL ERYYQTENED ESPFICSQPR ENGMRSCRSV PTLRGEGGGG
     PPCGLDYEAY NSSSNTTCVN WNQYYTNCSA GEHNPFKGAI NFDNIGYAWI AIFQRGAWLI
     GMPLYVVAGI VGSFFMINLC LVVIATQFSE TKQRESQLMR EQRVRFLSNA STLASFSEPG
     SCYEELLKYL VYILRKAARR LAQVSRAAGV RVGLLSSPAP LGGQETQPSS SCSRSHRRLS
     VHHLVHHHHH HHHHYHLGNG TLRAPRASPE IQDRDANGSR RLMLPPPSTP ALSGAPPGGA
     ESVHSFYHAD CHLEPVRCQA PPPRSPSEAS GRTVGSGKVY PTVHTSPPPE TLKEKALVEV
     AASSGPPTLT SLNIPPGPYS SMHKLLETQS TGACQSSCKI SSPCLKADSG ACGPESCPYC
     ARAGAGEVEL ADREMPDSDS EAVYEFTQDA QHSDLRDPHS RRQRSLGPDA EPSSVLAFWR
     LICDTFRKIV DSKYFGRGIM IAILVNTLSM GIEYHEQPEE LTNALEISNI VFTSLFALEM
     LLKLLVYGPF GYIKNPYNIF DGVIVVISVW EIVGQQGGGL SVLRTFRLMR VLKLVRFLPA
     LQRQLVVLMK TMDNVATFCM LLMLFIFIFS ILGMHLFGCK FASERDGDTL PDRKNFDSLL
     WAIVTVFQIL TQEDWNKVLY NGMASTSSWA ALYFIALMTF GNYVLFNLLV AILVEGFQAE
     EISKREDASG QLSCIQLPVD SQGGDANKSE SEPDFFSPSL DGDGDRKKCL ALVSLGEHPE
     LRKSLLPPLI IHTAATPMSL PKSTSTGLGE ALGPASRRTS SSGSAEPGAA HEMKSPPSAR
     SSPHSPWSAA SSWTSRRSSR NSLGRAPSLK RRSPSGERRS LLSGEGQESQ DEEESSEEER
     ASPAGSDHRH RGSLEREAKS SFDLPDTLQV PGLHRTASGR GSASEHQDCN GKSASGRLAR
     ALQPDDPPLD GDDADDEGNL SKGERVRAWI RARLPACCLE RDSWSAYIFP PQSRFRLLCH
     RIITHKMFDH VVLVIIFLNC ITIAMERPKI DPHSAERIFL TLSNYIFTAV FLAEMTVKVV
     ALGWCFGEQA YLRSSWNVLD GLLVLISVID ILVSMVSDSG TKILGMLRVL RLLRTLRPLR
     VISRAQGLKL VVETLMSSLK PIGNIVVICC AFFIIFGILG VQLFKGKFFV CQGEDTRNIT
     NKSDCAEASY RWVRHKYNFD NLGQALMSLF VLASKDGWVD IMYDGLDAVG VDQQPIMNHN
     PWMLLYFISF LLIVAFFVLN MFVGVVVENF HKCRQHQEEE EARRREEKRL RRLEKKRRNL
     MLDDVIASGS SASAASEAQC KPYYSDYSRF RLLVHHLCTS HYLDLFITGV IGLNVVTMAM
     EHYQQPQILD EALKICNYIF TVIFVLESVF KLVAFGFRRF FQDRWNQLDL AIVLLSIMGI
     TLEEIEVNAS LPINPTIIRI MRVLRIARVL KLLKMAVGMR ALLDTVMQAL PQVGNLGLLF
     MLLFFIFAAL GVELFGDLEC DETHPCEGLG RHATFRNFGM AFLTLFRVST GDNWNGIMKD
     TLRDCDQEST CYNTVISPIY FVSFVLTAQF VLVNVVIAVL MKHLEESNKE AKEEAELEAE
     LELEMKTLSP QPHSPLGSPF LWPGVEGPDS PDSPKPGALH PAAHARSASH FSLEHPTDRQ
     LFDTISLLIQ GSLEWELKLM DELAGPGGQP SAFPSAPSLG GSDPQIPLAE MEALSLTSEI
     VSEPSCSLAL TDDSLPDDMH TLLLSALESN MQPHPTELPG PDLLTVRKSG VSRTHSLPND
     SYMCRHGSTA EGPLGHRGWG LPKAQSGSVL SVHSQPADTS YILQLPKDAP HLLQPHSAPT
     WGTIPKLPPP GRSPLAQRPL RRQAAIRTDS LDVQGLGSRE DLLAEVSGPS PPLARAYSFW
     GQSSTQAQQH SRSHSKISKH MTPPAPCPGP EPNWGKGPPE TRSSLELDTE LSWISGDLLP
     PGGQEEPPSP RDLKKCYSVE AQSCQRRPTS WLDEQRRHSI AVSCLDSGSQ PHLGTDPSNL
     GGQPLGGPGS RPKKKLSPPS ITIDPPESQG PRPPPSPGIC LRRRAPSSDS KDPLASGPPD
     SMAASPSPKK DVLSLSGLSS DPADLDP
//
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