ID G3S588_GORGO Unreviewed; 399 AA.
AC G3S588; G3RHU6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Inositol polyphosphate-1-phosphatase {ECO:0000313|Ensembl:ENSGGOP00000023244.2};
GN Name=INPP1 {ECO:0000313|Ensembl:ENSGGOP00000023244.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000023244.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000023244.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000023244.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000023244.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the inositol monophosphatase superfamily.
CC {ECO:0000256|ARBA:ARBA00009759}.
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DR EMBL; CABD030017633; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030017634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004033009.1; XM_004032961.2.
DR RefSeq; XP_018877587.1; XM_019022042.1.
DR RefSeq; XP_018877588.1; XM_019022043.1.
DR RefSeq; XP_018877589.1; XM_019022044.1.
DR RefSeq; XP_018877590.1; XM_019022045.1.
DR STRING; 9593.ENSGGOP00000015225; -.
DR Ensembl; ENSGGOT00000015660.3; ENSGGOP00000015225.2; ENSGGOG00000015605.3.
DR Ensembl; ENSGGOT00000032984.2; ENSGGOP00000023244.2; ENSGGOG00000015605.3.
DR GeneID; 101129850; -.
DR KEGG; ggo:101129850; -.
DR CTD; 3628; -.
DR eggNOG; KOG3099; Eukaryota.
DR GeneTree; ENSGT00940000156785; -.
DR OMA; GSTFRWD; -.
DR OrthoDB; 5392231at2759; -.
DR TreeFam; TF314300; -.
DR Proteomes; UP000001519; Chromosome 2B.
DR Bgee; ENSGGOG00000015605; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0004441; F:inositol-1,4-bisphosphate 1-phosphatase activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR CDD; cd01640; IPPase; 1.
DR Gene3D; 3.40.190.80; -; 1.
DR Gene3D; 3.30.540.10; Fructose-1,6-Bisphosphatase, subunit A, domain 1; 1.
DR Gene3D; 4.10.460.10; Inositol Polyphosphate 1-phosphatase, domain 1; 1.
DR InterPro; IPR020583; Inositol_monoP_metal-BS.
DR InterPro; IPR000760; Inositol_monophosphatase-like.
DR InterPro; IPR020550; Inositol_monophosphatase_CS.
DR InterPro; IPR044897; INPP1_dom_1.
DR PANTHER; PTHR43028; 3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1; 1.
DR PANTHER; PTHR43028:SF3; INOSITOL POLYPHOSPHATE 1-PHOSPHATASE; 1.
DR Pfam; PF00459; Inositol_P; 1.
DR SUPFAM; SSF56655; Carbohydrate phosphatase; 1.
DR PROSITE; PS00629; IMP_1; 1.
DR PROSITE; PS00630; IMP_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
SQ SEQUENCE 399 AA; 43851 MW; C0E37F28038A4C86 CRC64;
MSDILRELLC VSEKAANIAR ACRQQETLFQ LLIEEKKEGE KNKKFAVDFK TLADVLVQEV
IKQNMENKFP GLEKNISGEE SNEFTNDLGE KITLRLCSTE EETAELLSKV LNGNKVASEA
LARVVHQDVA FTDPTLDSTE INVPQDILGI WVDPIDSTYQ YIKGSADIKS NQGIFPCGLQ
CVTILIGVYD IQTGVPLMGV INQPFVSRDP NTLRWKGQCY WGLSYMGTNM HSLQLTISRR
NGSETHTGNT GSEAAFSPSF SAVISTSEKE TVKAALSRVC GDRIFGAAGA GYKSLCVVQG
LVDIYIFSED TTFKWDSCAA HAILRAMGGG IVDLKECLER NPETGLDLPQ LVYHVENEGA
AGVDRWANKG GLIAYRSRKR LEAFLSLLVQ NLAPAETHT
//
