ID G3S7E2_GORGO Unreviewed; 655 AA.
AC G3S7E2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Striatin 3 {ECO:0000313|Ensembl:ENSGGOP00000024000.2};
GN Name=STRN3 {ECO:0000313|Ensembl:ENSGGOP00000024000.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000024000.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000024000.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000024000.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000024000.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat striatin family.
CC {ECO:0000256|ARBA:ARBA00009616}.
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DR EMBL; CABD030091597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030091598; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030091599; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030091600; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030091601; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030091602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030091603; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030091604; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSGGOT00000030775.2; ENSGGOP00000024000.2; ENSGGOG00000006096.3.
DR GeneTree; ENSGT00950000183095; -.
DR Proteomes; UP000001519; Chromosome 14.
DR Bgee; ENSGGOG00000006096; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:UniProt.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.5.300; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR013258; Striatin_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR15653; STRIATIN; 1.
DR PANTHER; PTHR15653:SF3; STRIATIN-3; 1.
DR Pfam; PF08232; Striatin; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 64..184
FT /note="Striatin N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08232"
FT REPEAT 334..375
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 387..420
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 440..472
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 577..618
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 37..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 197..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 83..131
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 655 AA; 71980 MW; 85053255DC53FE81 CRC64;
MDELAGGGGG GPGMAAPXXX XXXXXXXXXX XXXXXXXXXX XXXPASEGAG PAAGPELSRP
QQYTIPGILH YIQHEWARFE MERAHWEVER AELQARIAFL QGERKGQENL KKDLVRRIKM
LEYALKQERA KYHKLKYGTE LNQGDLKMPT FESEETKDTE APTAPQNSQL TWKQGRQLLR
QSSGDVLETF NFLENADDSD EDEENDMIEG IPEGKDKHRM NKHKIGNEGL AADLTDDPDT
EEALKEFDFL VTAEDGEGAG EARSSGDGTE WAEPITFPSG GGKSFIMGSD DVLLSVLGLG
DLADLTVTND ADYSYDLPAN KDAFRKTWNP KYTLRSHFDG VRALAFHPVE PVLVTASEDH
TLKLWNLQKT VPAKKSASLD VEPIYTFRAH IGPVLSLAIS SNGEQCFSGG IDATIQWWNM
PSPNVDPYDT YEPNVLAGTL VGHTDAVWGL AYSGIKNQLL SCSADGTVRL WNPQEKLPCI
CTYNGDKKHG IPTSVDFIGC DPAHMVTSFN TGSAVIYDLE TSQSLVILSS QVDSGLQSNN
HINRVVSHPT LPVTITAHED RHIKFFDNKT GKMIHSMVAH LDAVTSLAVD PNGIYLMSGS
HDCSIRLWNL DSKTCVQEIT AHRKKLDESI YDVAFHPSKA YIASAGADAL AKVFV
//
