ID G3S7K2_GORGO Unreviewed; 441 AA.
AC G3S7K2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=IF rod domain-containing protein {ECO:0000259|PROSITE:PS51842};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000024061.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000024061.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000024061.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000024061.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; CABD030040670; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3S7K2; -.
DR Ensembl; ENSGGOT00000029689.2; ENSGGOP00000024061.2; ENSGGOG00000022566.2.
DR eggNOG; ENOG502QURK; Eukaryota.
DR GeneTree; ENSGT00940000153339; -.
DR HOGENOM; CLU_012560_5_4_1; -.
DR TreeFam; TF317854; -.
DR Proteomes; UP000001519; Chromosome 5.
DR Bgee; ENSGGOG00000022566; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF46; IF ROD DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00038; Filament; 2.
DR Pfam; PF16208; Keratin_2_head; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 89..368
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 93..200
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 280..339
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 441 AA; 49032 MW; 72EE78F6BF2358F2 CRC64;
LSVTQKSYKV STSGPRAFSS HSYTSGPGAH ISSSSFSRVG SSCFRGGLGG GYGGASGVGG
ITAVTVSQSL LSPLVLEVDP DIQAVCTQEK EQIKTLNNKF ASFIDKVRFL EQQNKMLETK
WSFLQQQKTE KLKLEAELGN MQGLVEDFKY KYEDEINKRA EMENEFVLIK KDVDEAYMNK
VELESRLEGL TDEINFLRQL YEEEIWELQS WISDTSVVLS MDNSRSLDMN SIIAEVKAQY
EEIANRSQAE AESMYQMKDE ELQSLAGKHG DNLRCTKTKI SEMNWNISRL QAENEGLKGQ
RAFLEAAIAD AEQCGELAIK DLEAALQRAK QDMAWQLREY QELMNVRLAL DIEIATYKKL
LEGEESRLES GMQNMSIHTK TTSSYASGLS SAYGGLTSPG LSYGLGSSSF SRTSSSRAVV
VKKIETRDGK LVSESSDVLP K
//
