ID G3S8H8_GORGO Unreviewed; 1557 AA.
AC G3S8H8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=Eukaryotic translation initiation factor 4 gamma 1 {ECO:0000313|Ensembl:ENSGGOP00000024391.2};
GN Name=EIF4G1 {ECO:0000313|Ensembl:ENSGGOP00000024391.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000024391.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000024391.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000024391.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000024391.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the eukaryotic initiation factor 4G family.
CC {ECO:0000256|ARBA:ARBA00005775}.
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DR EMBL; CABD030025990; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030025991; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018878607.1; XM_019023062.1.
DR RefSeq; XP_018878608.1; XM_019023063.1.
DR Ensembl; ENSGGOT00000032932.2; ENSGGOP00000024391.2; ENSGGOG00000013919.3.
DR GeneTree; ENSGT00940000154648; -.
DR HOGENOM; CLU_001519_2_0_1; -.
DR OrthoDB; 92033at2759; -.
DR Proteomes; UP000001519; Chromosome 3.
DR Bgee; ENSGGOG00000013919; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:AgBase.
DR GO; GO:0008190; F:eukaryotic initiation factor 4E binding; ISS:AgBase.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd11559; W2_eIF4G1_like; 1.
DR Gene3D; 1.25.40.180; -; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR045208; IF4G.
DR InterPro; IPR003891; Initiation_fac_eIF4g_MI.
DR InterPro; IPR003890; MIF4G-like_typ-3.
DR InterPro; IPR003307; W2_domain.
DR PANTHER; PTHR23253; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA; 1.
DR PANTHER; PTHR23253:SF10; EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 1; 1.
DR Pfam; PF02847; MA3; 1.
DR Pfam; PF02854; MIF4G; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SMART; SM00544; MA3; 1.
DR SMART; SM00543; MIF4G; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS51366; MI; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 1199..1321
FT /note="MI"
FT /evidence="ECO:0000259|PROSITE:PS51366"
FT DOMAIN 1391..1557
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..233
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..432
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..543
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1017..1045
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1070..1099
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1100..1181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1557 AA; 171314 MW; 6E9290F1011AD795 CRC64;
MNTPSQPRQH FYPSRAQPPS SAASRVQSAA PARPGPAAHV YPAGSQVMMI PSQISYPASQ
GAYYIPGQGR STYVVPTQQY PVQPGAPGFY PGASPTEFGT YAGAYYPAQG VQQFPTGVAP
APVLMNQPPQ IAPKRERKTI RIRDPNQGGK DITEEIMSGA RTASTPTPPQ TGGGLEPQAN
GETPQVAVIV RPDDRSQGAI IADRPGLPGP EHSPSESQPS SPSPTPSPSP VLEPGSEPNL
AVLSIPGDTM TTIQMSVEES TPISRETGEP YRLSPEPTPL AEPILEVEVT LSKPVPESEF
SSSPLQAPTP LASHTVEIHE PNGMVPSEDL EPEVESSAEL APPPACPSES PVPIAPTAQP
EELLNGAPSP PAVDLSPVSE PEEQAKEVTA SVAPPTIPSA TPATAPSATS PAQEEEMEEE
EEEEEGEAGE AESEKGGEEL LPPESTPIPA NLSQNLEAAA ATQVAVSVPK RRRKIKELNK
KEAVGDLLDA FKEVNPAVPE VENQPPAGSN PGPESEGSSV PPRPEEADET WDSKEDKIHN
AENIQPGEQK YEYKSDQWKP LNLEEKKRYD REFLLGFQFI FASMQKPEGL PHISDVVLDK
ANKTPLRPLD PTRLQGINCG PDFTPSFANL GRTTLSTRGP PRGGPGGELP RGPQAGLGPR
RSQQGPRKEP RKIIATVLMT EDIKLNKAEK AWKPSSKRTA ADKDRGEEDA DGSKTQDLFR
RVRSILNKLT PQMFQQLMKQ VTQLAIDTEE RLKGVIDLIF EKAISEPNFS VAYANMCRCL
MALKVPTTEK PTVTVNFRKL LLNRCQKEFE KDKDDDEVFE KKQKEMDEAA SAEERGRLKE
ELEEARDIAR RRSLGNIKFI GELFKLKMLT EAIMHDCVVK LLKNHDEESL ECLCRLLTTI
GKDLDFEKAK PRMDQYFNQM EKIIKEKKTS SRIRFMLQDV LDLRGSNWVP RRGDQGPKTI
DQIHKEAEME EHREHIKVQQ LMAKGSDKRR GGPPGPPISR GLPLVDDGGW NTVPISKGSR
PIDTSRLTKI TKPGSIDSNN QLFAPGGRLS WGKGSSGGSG AKPSDAASEA ARPATSTLNR
FSALQQAVPT ESTDNRRVVQ RSSLSRERGE KAGDRGDRLE RSERGGDRGD RLDRARTPAT
KRSFSKEVEE RSRERPSQPE GLRKAASLTE DRDRGRDAVK REAALPSVSP PKAALSEEEL
EKKSKAIIEE YLHLNDMKEA VQCVQELASP SLLFIFVRHG VESTLERSAI AREHMGQLLH
QLLCAGHLST AQYYQGLYEI LELAEDMEID IPHVWLYLAE LVTPILQEGG VPMGELFREI
TKPLRPLGKA ASLLLEILGL LCKSMGPKKV GTLWREAGLS WKEFLPEGQD IGAFVAEQKV
EYTLGEESEA PGQRALPSEE LNRQLEKLLK EGSSNQRVFD WIEANLSEQQ IVSNTLVRAL
MTAVCYSAII FETPLRVDVA VLKARAKLLQ KYLCDEQKEL QALYALQALV VTLEQPPNLL
RMFFDALYDE DVVKEDAFYS WESSKDPAEQ QGKGVALKSV TAFFKWLREA EEESDHN
//
