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Database: UniProt
Entry: G3SCH8_GORGO
LinkDB: G3SCH8_GORGO
Original site: G3SCH8_GORGO 
ID   G3SCH8_GORGO            Unreviewed;      1160 AA.
AC   G3SCH8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   24-JAN-2024, entry version 57.
DE   RecName: Full=ATP-dependent RNA helicase DHX30 {ECO:0000256|ARBA:ARBA00039388};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
DE   AltName: Full=DEAH box protein 30 {ECO:0000256|ARBA:ARBA00042917};
GN   Name=DHX30 {ECO:0000313|Ensembl:ENSGGOP00000025806.2};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000025806.2, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000025806.2, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000025806.2, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22398555; DOI=10.1038/nature10842;
RA   Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA   Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA   McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA   Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA   Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA   Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA   Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA   Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA   Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA   Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA   Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA   Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA   Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT   "Insights into hominid evolution from the gorilla genome sequence.";
RL   Nature 483:169-175(2012).
RN   [3] {ECO:0000313|Ensembl:ENSGGOP00000025806.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid
CC       {ECO:0000256|ARBA:ARBA00004436}.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC       {ECO:0000256|ARBA:ARBA00008792}.
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DR   EMBL; CABD030021154; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030021155; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030021156; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030021157; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; G3SCH8; -.
DR   Ensembl; ENSGGOT00000024172.2; ENSGGOP00000025806.2; ENSGGOG00000004307.3.
DR   GeneTree; ENSGT00940000158279; -.
DR   Proteomes; UP000001519; Chromosome 3.
DR   Bgee; ENSGGOG00000004307; Expressed in testis and 6 other cell types or tissues.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   CDD; cd17976; DEXHc_DHX30; 1.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.30.160.20; -; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF257; ATP-DEPENDENT RNA HELICASE DHX30; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023271};
KW   Mitochondrion nucleoid {ECO:0000256|ARBA:ARBA00023271};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          410..578
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          620..793
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          117..165
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1160 AA;  130196 MW;  C73F287F7CC42DAB CRC64;
     VFKRKRTTVM DLLKEFPQPK NLLNSVIGRA LGISHAKDKL VYVHTNGPKK KKVTLHIKWP
     KSVEVEGYGS KKIDAERQAA AAACQLFKGW GLLGPRNELF DAAKYRVLAD RFGSPADSWW
     RPEPTMPPTS WRQLNPESIR PGGPGGLSRS LGREEEEDEE EELEEGTIDV TDFLSMTQQD
     SHAPLRDSRG SSFEMTDDDS AIRALTQFPL PKNLLAKVIQ IATSSSTAKN LMQFHTVGTK
     TKLSTLTLLW PCPMTFVAKG RRKAEAENKA AALACKKLKS LGLVDRNNEP LTHAMYNLAS
     LRELGETQRR PCTIQVPEPI LRKIETFLNH YPVENSWIAP ELRLQSDDIL PLGKDSGPLS
     DPITGKPYVP LLEAEEVRLS QSLLELWRRR GPVWQEAPQL PVDPHRDTIL NAIEQHPVVV
     ISGDTGCGKT TRIPQLLLER YVTEGRGARC NVIITQPRRI SAVSVAQRVS HELGPSLRRN
     VGFQVRLESK PPSRGGALLF CTVGILLRKL QSNPSLEGVS HVIVDEVHER DVNTDFLLIL
     LKGLQRLNPA LRLVLMSATG DNERFSRYFG GCPVIKVPGF MYPVKEHYLE DILAKLGKHQ
     YLHRHRHHES EDECALDLDL VTDLVLHIDA RGEPGGILCF LPGWQEIKGV QQRLQEALGM
     HESKYLILPV HSNIPMMDQK AIFQQPPVGV RKIVLATNIA ETSITINDIV HVVDSGLHKE
     ERYDLKTKVS CLETVWVSRA NVIQRRGRAG RCQSGFAYHL FPRSRLEKMV PFQVPEILRT
     PLENLVLQAK IHMPEKTAVE FLSKAVDSPN IKAVDEAVIL LQEIGVLDQR EYLTTLGQRL
     AHISTDPRLA KAIVLAAIFR CLHPLLVVVS CLTRDPFSSS LQNRAEVDKV KALLSHDSGS
     DHLAFVRAVA GWEEVLRWQD RSSRENYLEE NLLYAPSLRF IHGLIKQFSE NIYEAFLVGK
     PSDCTLASAQ CNEYSEEEEL VKGVLMAGLY PNLIQVRQGK VTRQGKFKPN SVTYRTKSGN
     ILLHKSTINR EATRLRSRWL TYFMAVKSNG SVFVRDSSQV HPLAVLLLTD GDVHIRDDGR
     RATISLSDSD LLRLEGDSRT VRLLKELRRA LGRMVERSLR SELAALPPSV QEEHGQLLAL
     LAELLRGPCG SFDVRKTADD
//
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