ID G3SFG7_GORGO Unreviewed; 324 AA.
AC G3SFG7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=CYFIP related Rac1 interactor B {ECO:0000313|Ensembl:ENSGGOP00000026853.2};
GN Name=CYRIB {ECO:0000313|Ensembl:ENSGGOP00000026853.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000026853.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000026853.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000026853.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000026853.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Interacts with RAC1 (GTP-bound form preferentially).
CC {ECO:0000256|ARBA:ARBA00011307}.
CC -!- SIMILARITY: Belongs to the CYRI family.
CC {ECO:0000256|ARBA:ARBA00005778}.
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DR EMBL; CABD030061094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030061095; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018888059.1; XM_019032514.1.
DR RefSeq; XP_018888060.1; XM_019032515.1.
DR RefSeq; XP_018888061.1; XM_019032516.1.
DR RefSeq; XP_018888062.1; XM_019032517.1.
DR RefSeq; XP_018888063.1; XM_019032518.1.
DR RefSeq; XP_018888064.1; XM_019032519.1.
DR AlphaFoldDB; G3SFG7; -.
DR SMR; G3SFG7; -.
DR STRING; 9593.ENSGGOP00000026853; -.
DR Ensembl; ENSGGOT00000034206.2; ENSGGOP00000026853.2; ENSGGOG00000006550.3.
DR GeneID; 101140411; -.
DR KEGG; ggo:101140411; -.
DR CTD; 51571; -.
DR eggNOG; KOG3951; Eukaryota.
DR GeneTree; ENSGT00390000015159; -.
DR InParanoid; G3SFG7; -.
DR OMA; EYRSRFN; -.
DR OrthoDB; 2785093at2759; -.
DR TreeFam; TF314541; -.
DR Proteomes; UP000001519; Chromosome 8.
DR Bgee; ENSGGOG00000006550; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0005929; C:cilium; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0023030; F:MHC class Ib protein binding, via antigen binding groove; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0071219; P:cellular response to molecule of bacterial origin; IEA:Ensembl.
DR GO; GO:0030837; P:negative regulation of actin filament polymerization; IEA:Ensembl.
DR GO; GO:0051058; P:negative regulation of small GTPase mediated signal transduction; IEA:Ensembl.
DR GO; GO:2000568; P:positive regulation of memory T cell activation; IEA:Ensembl.
DR GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
DR GO; GO:0001916; P:positive regulation of T cell mediated cytotoxicity; IEA:Ensembl.
DR GO; GO:0032729; P:positive regulation of type II interferon production; IEA:Ensembl.
DR GO; GO:0030334; P:regulation of cell migration; IEA:Ensembl.
DR GO; GO:0050920; P:regulation of chemotaxis; IEA:Ensembl.
DR GO; GO:2000114; P:regulation of establishment of cell polarity; IEA:Ensembl.
DR GO; GO:0090140; P:regulation of mitochondrial fission; IEA:Ensembl.
DR InterPro; IPR039789; CYRI.
DR InterPro; IPR009828; CYRIA/CYRIB_Rac1-bd.
DR PANTHER; PTHR12422:SF3; CYFIP-RELATED RAC1 INTERACTOR B; 1.
DR PANTHER; PTHR12422; UNCHARACTERIZED; 1.
DR Pfam; PF07159; CYRIA-B_Rac1-bd; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 18..320
FT /note="CYRIA/CYRIB Rac1 binding"
FT /evidence="ECO:0000259|Pfam:PF07159"
SQ SEQUENCE 324 AA; 36748 MW; EE370E3D170A6E38 CRC64;
MGNLLKVLTC TDLEQGPNFF LDFENAQPTE SEKEIYNQVN VVLKDAEGIL EDLQSYRGAG
HEIREAIQHP ADEKLQEKAW GAVVPLVGKL KKFYEFSQRL EAALRGLLGA LTSTPYSPTQ
HLEREQALAK QFAEILHFTL RFDELKMTNP AIQNDFSYYR RTLSRMRINN VPAEGENEVN
NELANRMSLF YAEATPMLKT LSDATTKFVS ENKNLPIENT TDCLSTMASV CRVMLETPEY
RSRFTNEETV SFCLRVMVGV IILYDHVHPV GAFAKTSKID MKGCIKVLKD QPPNSVEGLL
NALRYTTKHL NDETTSKQIK SMLQ
//
