ID G3SG07_GORGO Unreviewed; 172 AA.
AC G3SG07; G3QE62; G3RNX8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 {ECO:0000256|ARBA:ARBA00016384, ECO:0000256|PIRNR:PIRNR017016};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000027043.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000027043.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000027043.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000027043.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000256|PIRNR:PIRNR017016}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000256|ARBA:ARBA00011533}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC Mitochondrion inner membrane {ECO:0000256|PIRNR:PIRNR017016}.
CC Mitochondrion intermembrane space {ECO:0000256|ARBA:ARBA00004569}.
CC -!- SIMILARITY: Belongs to the complex I NDUFA8 subunit family.
CC {ECO:0000256|ARBA:ARBA00010705, ECO:0000256|PIRNR:PIRNR017016}.
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DR EMBL; CABD030066468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018888523.1; XM_019032978.1.
DR Ensembl; ENSGGOT00000000562.3; ENSGGOP00000000549.2; ENSGGOG00000000557.3.
DR Ensembl; ENSGGOT00000031090.2; ENSGGOP00000017496.2; ENSGGOG00000000557.3.
DR Ensembl; ENSGGOT00000031811.2; ENSGGOP00000027043.2; ENSGGOG00000000557.3.
DR Ensembl; ENSGGOT00000061778.1; ENSGGOP00000046188.1; ENSGGOG00000000557.3.
DR GeneTree; ENSGT00390000008938; -.
DR TreeFam; TF105633; -.
DR Proteomes; UP000001519; Chromosome 9.
DR Bgee; ENSGGOG00000000557; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:InterPro.
DR InterPro; IPR010625; CHCH.
DR InterPro; IPR016680; NDUFA8.
DR PANTHER; PTHR13344:SF0; NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8; 1.
DR PANTHER; PTHR13344; NADH-UBIQUINONE OXIDOREDUCTASE; 1.
DR Pfam; PF06747; CHCH; 1.
DR PIRSF; PIRSF017016; NDUA8; 1.
DR PROSITE; PS51808; CHCH; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Electron transport {ECO:0000256|ARBA:ARBA00022982,
KW ECO:0000256|PIRNR:PIRNR017016}; Membrane {ECO:0000256|PIRNR:PIRNR017016};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW ECO:0000256|PIRNR:PIRNR017016};
KW Mitochondrion inner membrane {ECO:0000256|PIRNR:PIRNR017016};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Respiratory chain {ECO:0000256|ARBA:ARBA00022660,
KW ECO:0000256|PIRNR:PIRNR017016};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR017016}.
FT DOMAIN 78..111
FT /note="CHCH"
FT /evidence="ECO:0000259|Pfam:PF06747"
FT REGION 134..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..152
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 172 AA; 20094 MW; 10606163B29E1153 CRC64;
MPGIVELPTL EELKVDEVKI SSAVLKAAAH HYGAQCDKPN KEFMLCRWEE KDPRRCLEEG
KLVNKCALDF FRQIKRHCAE PFTEYWTCID YTGQQLFRHC CKQQAKFDEC VLDKLVWVRP
DLGELSKVTK VKTDRPLPEN PYHSRPRPDP SPEIEGDLQP ATHGSRFYFW TK
//
