ID G3SG12_GORGO Unreviewed; 541 AA.
AC G3SG12;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Phospholipase A2 group IVC {ECO:0000313|Ensembl:ENSGGOP00000027048.2};
GN Name=PLA2G4C {ECO:0000313|Ensembl:ENSGGOP00000027048.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000027048.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000027048.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000027048.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000027048.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-
CC 3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-
CC hexadecanoyl-sn-glycero-3-phosphocholine + H(+);
CC Xref=Rhea:RHEA:40427, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:32395, ChEBI:CHEBI:72998, ChEBI:CHEBI:73003;
CC Evidence={ECO:0000256|ARBA:ARBA00023922};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:40428;
CC Evidence={ECO:0000256|ARBA:ARBA00023922};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-
CC glycero-3-phosphocholine + a fatty acid + H(+); Xref=Rhea:RHEA:15801,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28868,
CC ChEBI:CHEBI:57643, ChEBI:CHEBI:58168; EC=3.1.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00023422};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15802;
CC Evidence={ECO:0000256|ARBA:ARBA00023422};
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DR EMBL; CABD030114158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030114159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030114160; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030114161; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030114162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030114163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030114164; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030114165; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030114166; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030114167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018871600.1; XM_019016055.1.
DR AlphaFoldDB; G3SG12; -.
DR STRING; 9593.ENSGGOP00000027048; -.
DR Ensembl; ENSGGOT00000022645.2; ENSGGOP00000027048.2; ENSGGOG00000013321.3.
DR eggNOG; KOG1325; Eukaryota.
DR GeneTree; ENSGT01030000234606; -.
DR InParanoid; G3SG12; -.
DR OMA; KNICYLQ; -.
DR TreeFam; TF325228; -.
DR Proteomes; UP000001519; Chromosome 19.
DR Bgee; ENSGGOG00000013321; Expressed in heart and 5 other cell types or tissues.
DR GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0005811; C:lipid droplet; IEA:Ensembl.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:Ensembl.
DR GO; GO:0005635; C:nuclear envelope; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0047498; F:calcium-dependent phospholipase A2 activity; IBA:GO_Central.
DR GO; GO:0005544; F:calcium-dependent phospholipid binding; IBA:GO_Central.
DR GO; GO:0047499; F:calcium-independent phospholipase A2 activity; IEA:Ensembl.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:Ensembl.
DR GO; GO:0008374; F:O-acyltransferase activity; IEA:Ensembl.
DR GO; GO:0046475; P:glycerophospholipid catabolic process; IBA:GO_Central.
DR GO; GO:0140042; P:lipid droplet formation; IEA:Ensembl.
DR GO; GO:0036151; P:phosphatidylcholine acyl-chain remodeling; IEA:Ensembl.
DR GO; GO:0036152; P:phosphatidylethanolamine acyl-chain remodeling; IEA:Ensembl.
DR GO; GO:0006663; P:platelet activating factor biosynthetic process; IEA:Ensembl.
DR CDD; cd07202; cPLA2_Grp-IVC; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002642; LysoPLipase_cat_dom.
DR PANTHER; PTHR10728; CYTOSOLIC PHOSPHOLIPASE A2; 1.
DR PANTHER; PTHR10728:SF39; CYTOSOLIC PHOSPHOLIPASE A2 GAMMA; 1.
DR Pfam; PF01735; PLA2_B; 1.
DR SMART; SM00022; PLAc; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51210; PLA2C; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00555};
KW Lipid degradation {ECO:0000256|PROSITE-ProRule:PRU00555};
KW Lipid metabolism {ECO:0000256|PROSITE-ProRule:PRU00555};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 1..541
FT /note="PLA2c"
FT /evidence="ECO:0000259|PROSITE:PS51210"
SQ SEQUENCE 541 AA; 60858 MW; 40689CE0080FB218 CRC64;
MGSSEVSIIP GLQTEEKAAV ERRRLHVLKA LKKLRIEADE APVVAVLGSG GGLRAHIACL
GVLSEMKEQG LLDAVTYLAG VSGSTWAISS LYTNDGDMEA LEADLKHRFT RQEWDVAKSL
QKTIQAARSE NYSLTDFWAY MVISKQTREL PESHLSNMKK PVEEGTLPYP IFAAIDNDLQ
PSWQEARAPE TWFEFTPHHA GFPALGAYVS ITHFGSKFKK GRLVRTHPER DLTFLRGLWG
SALGNTEVIR EYIFDQLRNL TLKGLWRRAV ANAKSTGCLI FARLLRLQES SQGEHPPPED
EGGEPEHTWL TEMLENWTRT SLEKQEQPHE DPERKGTLSN FMDFVKKTGI CASKWEWGTT
HNFLYKHGGI RDTIMSSRKH LHLVDAGLAI NTPFPLVLSP TREVHLILSF DFSAGDPFET
IRATADYCRR HKIPFPQVEK AELDLWSKAP ASCYILKGET GPVVMHFPLF NIDACGGDIE
AWSDTYDTFK LADTYTLDVV VLLLALAKKN VRENKKKILR ELMNVAGLYY PKDSARSCCL
A
//
