ID G3SG95_GORGO Unreviewed; 425 AA.
AC G3SG95;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Synaptotagmin 6 {ECO:0000313|Ensembl:ENSGGOP00000027131.2};
GN Name=SYT6 {ECO:0000313|Ensembl:ENSGGOP00000027131.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000027131.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000027131.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000027131.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000027131.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the synaptotagmin family.
CC {ECO:0000256|ARBA:ARBA00006996}.
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DR EMBL; CABD030005456; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030005457; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018876277.1; XM_019020732.1.
DR RefSeq; XP_018876286.1; XM_019020741.1.
DR AlphaFoldDB; G3SG95; -.
DR Ensembl; ENSGGOT00000033857.2; ENSGGOP00000027131.2; ENSGGOG00000014743.3.
DR GeneTree; ENSGT00940000157665; -.
DR HOGENOM; CLU_023008_8_3_1; -.
DR Proteomes; UP000001519; Chromosome 1.
DR Bgee; ENSGGOG00000014743; Expressed in adult mammalian kidney and 2 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR CDD; cd08385; C2A_Synaptotagmin-1-5-6-9-10; 1.
DR CDD; cd08403; C2B_Synaptotagmin-3-5-6-9-10; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001565; Synaptotagmin.
DR PANTHER; PTHR10024; SYNAPTOTAGMIN; 1.
DR PANTHER; PTHR10024:SF45; SYNAPTOTAGMIN-6; 1.
DR Pfam; PF00168; C2; 2.
DR PRINTS; PR00360; C2DOMAIN.
DR PRINTS; PR00399; SYNAPTOTAGMN.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR PROSITE; PS50004; C2; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 144..265
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 276..409
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 425 AA; 48423 MW; F41B2A9895DFFCF5 CRC64;
MPWRNKEASS PSSANPPLEA LQSPSFRGNM ADKLKDPSTL GFLEAAVKIS HTSPDIPAEV
QMSVKEHIMR HTRLQRQTTE PASSTRHTSF KRHLPRQMHV SSVDYGNELP PAAEQPTSIG
RIKPELYKQK SVDGEDAKSE ATKSCGKINF SLRYDYETET LIVHILKAFD LPAKDFCGSS
DPYVKIYLLP DRKCKLQTRV HRKTLNPTFD ENFHFPVPYE ELADRKLHLS VFDFDRFSRH
DMIGEVILDN LFEASDLSRE TSIWKDIQYA TSESVDLGEI MFSLCYLPTA GRLTLTVIKC
RNLKAMDITG YSDPYVKVSL LCDGRRLKKK KTTIKKNTLN PVYNEAIIFD IPPENMDQVS
LLISVMDYDR VGHNEIIGVC RVGITAEGLG RDHWNEMLAY PRKPIAHWHS LVEVKKSFKE
GNPRL
//
