ID G3SGG2_GORGO Unreviewed; 595 AA.
AC G3SGG2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Ral guanine nucleotide dissociation stimulator like 3 {ECO:0000313|Ensembl:ENSGGOP00000027198.2};
GN Name=RGL3 {ECO:0000313|Ensembl:ENSGGOP00000027198.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000027198.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000027198.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000027198.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000027198.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030111651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030111652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030111653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030111654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030111655; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3SGG2; -.
DR STRING; 9593.ENSGGOP00000027198; -.
DR Ensembl; ENSGGOT00000028899.2; ENSGGOP00000027198.2; ENSGGOG00000022422.2.
DR eggNOG; KOG3629; Eukaryota.
DR GeneTree; ENSGT00940000161935; -.
DR HOGENOM; CLU_010252_0_2_1; -.
DR InParanoid; G3SGG2; -.
DR OMA; RLSWVIE; -.
DR TreeFam; TF315204; -.
DR Proteomes; UP000001519; Chromosome 19.
DR Bgee; ENSGGOG00000022422; Expressed in adult mammalian kidney and 5 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR CDD; cd17212; RA_RGL3; 1.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR030750; RGL3_RA.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF220; RAL GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR-LIKE 3; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 16..146
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 126..384
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 498..585
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 276..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..492
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 438..463
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 595 AA; 65244 MW; FC78D4A7817A32FD CRC64;
APSPIANTFL HYRTSKVRVL RAARLERLVG ELVSGDREQD PSFMPAFLAT YRTFVPTARL
LGFLLPPVPP PPPPGVEIKK TAVQDLSFNK NLPPRVAQTS DLHSSEACAE EEEGLMPQGP
QLLDFSVDEV AEQLTLMDLE LFSKVRPYEC LGSVWSQRDR PGAAGASPTV RATVAQFNTV
TGCVLGSVLG APGLAAPQRA QRLEKWIRIA QRCRELRNFS SLRAILSALQ SNPIYRLKRS
WGAVSREPLS TFRKLSQIFS DENNHLSSRE ILFQEEATEG SQEEDNTPGS LPPKPPPGPV
PYLGTFLTDL VMLDTALPDV LEGDLINFEK RRKEWEILAR IQQLQRRCQS YTLSPHPPIL
AALHAQHQLT EEQSYRLSWV IEPPAASCPS SPRIRRRISL TKRLSAKLSR EKSSSPSGSP
GDPSSPTSSL CISPSVSPGS PPSSPRSRDA PAGSPPASPG PQGPSTKLPL SLDLPSPRPF
ALPLGSPGIP LPAQQNSEAR VIRVSIDNDH GNLYRSILLT SQDKAPSVVR RALQKHNVPQ
PWARDYQLFQ VLPGDRVLLI PDNANVFYAM SPVAPGDFML RRKEGTRNTL SVSPS
//
