GenomeNet

Database: UniProt
Entry: G3SHE4_GORGO
LinkDB: G3SHE4_GORGO
Original site: G3SHE4_GORGO 
ID   G3SHE4_GORGO            Unreviewed;       437 AA.
AC   G3SHE4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   31-JUL-2019, entry version 44.
DE   SubName: Full=ETS variant 6 {ECO:0000313|Ensembl:ENSGGOP00000027532};
GN   Name=ETV6 {ECO:0000313|Ensembl:ENSGGOP00000027532};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000027532, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000027532, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000027532}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSGGOP00000027532}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22398555; DOI=10.1038/nature10842;
RA   Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA   Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA   McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C.,
RA   Xue Y., Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V.,
RA   Beal K., Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A.,
RA   Gu Y., Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K.,
RA   Lunter G., Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D.,
RA   Phillips A.D., Prado-Martinez J., Rogers A.S., Sajjadian S.,
RA   Schmidt D., Shaw K., Simpson J.T., Stenson P.D., Turner D.J.,
RA   Vigilant L., Vilella A.J., Whitener W., Zhu B., Cooper D.N.,
RA   de Jong P., Dermitzakis E.T., Eichler E.E., Flicek P., Goldman N.,
RA   Mundy N.I., Ning Z., Odom D.T., Ponting C.P., Quail M.A., Ryder O.A.,
RA   Searle S.M., Warren W.C., Wilson R.K., Schierup M.H., Rogers J.,
RA   Tyler-Smith C., Durbin R.;
RT   "Insights into hominid evolution from the gorilla genome sequence.";
RL   Nature 483:169-175(2012).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594391}.
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DR   EMBL; CABD030082883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030082884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030082885; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030082886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030082887; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030082888; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSGGOT00000034021; ENSGGOP00000027532; ENSGGOG00000001540.
DR   GeneTree; ENSGT00940000159508; -.
DR   Proteomes; UP000001519; Chromosome 12.
DR   Bgee; ENSGGOG00000001540; Expressed in 6 organ(s), highest expression level in liver.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   DNA-binding {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT   DOMAIN       25    109       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      324    405       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION      143    247       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS    210    247       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   437 AA;  51329 MW;  517F269BCC72F5D8 CRC64;
     SYTPPESPVP SYASSTPLHV PVPRALRMEE DSIRLPAHLR LQPIYWSRDD VAQWLKWAEN
     EFSLRPIDSN TFEMNGKALL LLTKEDFRYR SPHSGDVLYE LLQHILKQRK PRILFSPFFH
     PGNSIHTQPE VILHQNHEED NCVQRTPRPS VDNVHHNPPT IELLHRSRSP ITTNHRPSPD
     PEQRPLRSPL DNMIRRLSPA ERAQGPRPHQ ENNHQESYPL SVSPMENNHC PASSESHPKP
     SSPRQESTRV IQLMPSPIMH PLILNPRHSM DFKQSRLSED GLHREGKPIN LSHREDLAYM
     NHIMVSVSPP EEHAMPIGRI ADCRLLWDYV YQLLSDSRYE NFIRWEDKES KIFRIVDPNG
     LARLWGNHKN RTNMTYEKMS RALRHYYKLN IIRKEPGQRL LFRFMKTPDE IMSGRTDRLE
     HLESQELDEQ IYQEDEC
//
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