ID G3SI77_GORGO Unreviewed; 540 AA.
AC G3SI77;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Solute carrier family 6 member 11 {ECO:0000313|Ensembl:ENSGGOP00000027817.2};
GN Name=SLC6A11 {ECO:0000313|Ensembl:ENSGGOP00000027817.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000027817.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000027817.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000027817.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000027817.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CABD030019867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030019868; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030019869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G3SI77; -.
DR Ensembl; ENSGGOT00000024655.2; ENSGGOP00000027817.2; ENSGGOG00000000379.3.
DR GeneTree; ENSGT00940000157569; -.
DR HOGENOM; CLU_006855_9_5_1; -.
DR Proteomes; UP000001519; Chromosome 3.
DR Bgee; ENSGGOG00000000379; Expressed in cerebellum and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0071705; P:nitrogen compound transport; IEA:UniProt.
DR GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR037272; SNS_sf.
DR PANTHER; PTHR11616:SF124; SODIUM- AND CHLORIDE-DEPENDENT GABA TRANSPORTER 3; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 2.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 132..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..371
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 377..401
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 422..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 540 AA; 60204 MW; 19C98BE42D8D5EE2 CRC64;
MTAEKALPLG NGKAAEEARE SEAPGGGCSS GGAAPARDPR DKRDKAVHER GHWNNKVEFV
LSVAGEIIGL GNVWRFPYLC YKNGGENCVE FQKLNVSNYS HVSLQNATSP VMEFWEHRVL
AISDGIEHIG NLRWELALCL LAAWTICYFC IWKGTKSTGK VVYVTATFPY IMLLILLIRG
VTLPGASEGI KFYLYPDLSR LSDPQVWVDA GTQIFFSYAI CLGCLTALGS YNNYNNNCYR
DCIMLCCLNS GTSFVAGFAI FSVLGFMAYE QGVPIAEVAE SGPGLAFIAY PKAVTMMPLS
PLWATLFFMM LIFLGLDSQF VCVESLVTAV VDMYPKVFRR GYRRELLILA LSVISYFLGL
VMLTEGGMYI FQLFDSYAAS GMCLLFVAIF ECICIGWVYG SNRFYDNIED MIGYRPPSLI
KWCWKIMTPG ICAGIFIFFL IKYKPLKYNN IYTYPAWGYG IGWLMALSSM LCIPLWICIT
VWKTEGTLPE KLQKLTTPST DLKMRGKLGV SPRMVTVNDC DAKLKSDGTI AAITEKETHF
//
