ID G3SIS4_GORGO Unreviewed; 1228 AA.
AC G3SIS4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 2.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSGGOP00000028014.2};
GN Name=EVC2 {ECO:0000313|Ensembl:ENSGGOP00000028014.2};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000028014.2, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000028014.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000028014.2, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000028014.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; CABD030027005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030027006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030027007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030027008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030027009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030027010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004038432.1; XM_004038384.2.
DR RefSeq; XP_004038433.1; XM_004038385.1.
DR AlphaFoldDB; G3SIS4; -.
DR Ensembl; ENSGGOT00000030344.2; ENSGGOP00000028014.2; ENSGGOG00000013705.3.
DR GeneID; 101136471; -.
DR KEGG; ggo:101136471; -.
DR CTD; 132884; -.
DR eggNOG; ENOG502QQ5U; Eukaryota.
DR GeneTree; ENSGT00940000154127; -.
DR OMA; IFFAQIK; -.
DR OrthoDB; 4261679at2759; -.
DR TreeFam; TF331379; -.
DR Proteomes; UP000001519; Chromosome 4.
DR Bgee; ENSGGOG00000013705; Expressed in adult mammalian kidney and 5 other cell types or tissues.
DR GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR InterPro; IPR022076; Limbin.
DR InterPro; IPR026501; Limbin/EVC.
DR PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR Pfam; PF12297; EVC2_like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 219..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 704..736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 383..410
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 927..961
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1228 AA; 139913 MW; E132771E269DAE40 CRC64;
MIWPKVECCH FKTAVEAPLG MKLDKKMEVF IPLSTSAASS GPWAHSLFAF IPSWPKKNLF
KRESPITHHL YGDISREVRG TSENGVIFQK CALVSGSSEA QTARIWLLVN NTKTTSSANL
SELLLLDSIA GLTIWDSIGN RTSEGFQAFS KKFLQVGDAF AVSYAATLQA GDLGNGESLK
LPAQLTFQSS SRNRTQLKAL FSITAEENIT VLPHHSLHAA GFFIAFLLSL VLTWAALFLM
VRYQCLKGNM LTRHRVWQYE SKLEPLPFTS ADGVNEDLSL NDQMIDILSS EDPGSMLQAL
EELEIATLNR ADADLEACRT QISKDIIALL LKNLTSSGHL SLQVERKMSA VFKKQFLLLE
NEIQEEYDRK MVALTAECDL ETRKKMENQY QREMMAMEEA EELLKRASER SAVECSNLLR
TLHGLEQEHL RKSLALQQEE DFAKAHRQLA VFQRNELRSI FFTQIKSAIF KGELKPEAAK
MLLQNYSKIQ ENVEELMDFF QASKRYHLSK RFGHREYLVQ NLQSSETRVQ GLLSTAAAQL
THLIQKHERA GYLDEDQMEM LLERAQTEVF SIKQKLDNDL KQEKKKLHQK LITKRRQELL
QKHREQRREQ VSIGEAFQAV EDAGQYLHQR RSLMEEHGAA LEELQERLDQ AALDDLRTLT
LSLFEKATDE LRRLQNSAMT QELLKRGVPW LFLQQILEEH GKEMAARAEQ LEGEERDRDQ
EGVQSVRQRL KDDAPEAVTE EQAELRRWEH LIFMKLCSSV FSLSEEELLR MRQEVHGCFA
QMDRSLALPK IRARVLLQQF QTAWREAEFV KLDQAVAAPE LQQQSKVRKS RSKSKSKGEL
LKKCIEDKIH LCEEQASEDL VEKVRGELLR ERVQRMEAQE GGFAQSLVAL QFQKASRVTE
TLSAYTALLS IQDLLLEELS ASEMLTKSAC TQILESHSRE LQELERKLED QLMQQEAAQQ
QQALASWQQW VADGPGILNE PGEVDSERQV STALQQALSK SQTLLEQHQQ CLREEQQNSV
VLEDLLENME ADTFATLCSQ ELKLASYLAR MAMVPGATLR RLLSVVLPTA SQPQLLALLD
SATERHADHA AESDGGVEQV DVGRRRKHQS WWQALDGKLR GDLISRGLEK MLWARKRKQS
ILKKTCLPLR ERMIFSGKGS WPHLSLEPIG ELAPVPIVGA ETIDLLNTGE KLFIFRNPKE
PEISLHVPPR KKKNFLNAKK AMRALGMD
//