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Database: UniProt
Entry: G3SIS4_GORGO
LinkDB: G3SIS4_GORGO
Original site: G3SIS4_GORGO 
ID   G3SIS4_GORGO            Unreviewed;      1228 AA.
AC   G3SIS4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 2.
DT   24-JAN-2024, entry version 56.
DE   SubName: Full=EvC ciliary complex subunit 2 {ECO:0000313|Ensembl:ENSGGOP00000028014.2};
GN   Name=EVC2 {ECO:0000313|Ensembl:ENSGGOP00000028014.2};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000028014.2, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000028014.2, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000028014.2, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22398555; DOI=10.1038/nature10842;
RA   Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA   Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA   McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA   Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA   Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA   Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA   Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA   Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA   Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA   Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA   Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA   Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA   Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT   "Insights into hominid evolution from the gorilla genome sequence.";
RL   Nature 483:169-175(2012).
RN   [3] {ECO:0000313|Ensembl:ENSGGOP00000028014.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium membrane
CC       {ECO:0000256|ARBA:ARBA00004309}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
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DR   EMBL; CABD030027005; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030027006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030027007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030027008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030027009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030027010; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_004038432.1; XM_004038384.2.
DR   RefSeq; XP_004038433.1; XM_004038385.1.
DR   AlphaFoldDB; G3SIS4; -.
DR   Ensembl; ENSGGOT00000030344.2; ENSGGOP00000028014.2; ENSGGOG00000013705.3.
DR   GeneID; 101136471; -.
DR   KEGG; ggo:101136471; -.
DR   CTD; 132884; -.
DR   eggNOG; ENOG502QQ5U; Eukaryota.
DR   GeneTree; ENSGT00940000154127; -.
DR   OMA; IFFAQIK; -.
DR   OrthoDB; 4261679at2759; -.
DR   TreeFam; TF331379; -.
DR   Proteomes; UP000001519; Chromosome 4.
DR   Bgee; ENSGGOG00000013705; Expressed in adult mammalian kidney and 5 other cell types or tissues.
DR   GO; GO:0060170; C:ciliary membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.
DR   GO; GO:0007224; P:smoothened signaling pathway; IEA:InterPro.
DR   InterPro; IPR022076; Limbin.
DR   InterPro; IPR026501; Limbin/EVC.
DR   PANTHER; PTHR16795:SF14; LIMBIN; 1.
DR   PANTHER; PTHR16795; LIMBIN/ELLIS-VAN CREVELD PROTEIN; 1.
DR   Pfam; PF12297; EVC2_like; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        219..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          704..736
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          383..410
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          927..961
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1228 AA;  139913 MW;  E132771E269DAE40 CRC64;
     MIWPKVECCH FKTAVEAPLG MKLDKKMEVF IPLSTSAASS GPWAHSLFAF IPSWPKKNLF
     KRESPITHHL YGDISREVRG TSENGVIFQK CALVSGSSEA QTARIWLLVN NTKTTSSANL
     SELLLLDSIA GLTIWDSIGN RTSEGFQAFS KKFLQVGDAF AVSYAATLQA GDLGNGESLK
     LPAQLTFQSS SRNRTQLKAL FSITAEENIT VLPHHSLHAA GFFIAFLLSL VLTWAALFLM
     VRYQCLKGNM LTRHRVWQYE SKLEPLPFTS ADGVNEDLSL NDQMIDILSS EDPGSMLQAL
     EELEIATLNR ADADLEACRT QISKDIIALL LKNLTSSGHL SLQVERKMSA VFKKQFLLLE
     NEIQEEYDRK MVALTAECDL ETRKKMENQY QREMMAMEEA EELLKRASER SAVECSNLLR
     TLHGLEQEHL RKSLALQQEE DFAKAHRQLA VFQRNELRSI FFTQIKSAIF KGELKPEAAK
     MLLQNYSKIQ ENVEELMDFF QASKRYHLSK RFGHREYLVQ NLQSSETRVQ GLLSTAAAQL
     THLIQKHERA GYLDEDQMEM LLERAQTEVF SIKQKLDNDL KQEKKKLHQK LITKRRQELL
     QKHREQRREQ VSIGEAFQAV EDAGQYLHQR RSLMEEHGAA LEELQERLDQ AALDDLRTLT
     LSLFEKATDE LRRLQNSAMT QELLKRGVPW LFLQQILEEH GKEMAARAEQ LEGEERDRDQ
     EGVQSVRQRL KDDAPEAVTE EQAELRRWEH LIFMKLCSSV FSLSEEELLR MRQEVHGCFA
     QMDRSLALPK IRARVLLQQF QTAWREAEFV KLDQAVAAPE LQQQSKVRKS RSKSKSKGEL
     LKKCIEDKIH LCEEQASEDL VEKVRGELLR ERVQRMEAQE GGFAQSLVAL QFQKASRVTE
     TLSAYTALLS IQDLLLEELS ASEMLTKSAC TQILESHSRE LQELERKLED QLMQQEAAQQ
     QQALASWQQW VADGPGILNE PGEVDSERQV STALQQALSK SQTLLEQHQQ CLREEQQNSV
     VLEDLLENME ADTFATLCSQ ELKLASYLAR MAMVPGATLR RLLSVVLPTA SQPQLLALLD
     SATERHADHA AESDGGVEQV DVGRRRKHQS WWQALDGKLR GDLISRGLEK MLWARKRKQS
     ILKKTCLPLR ERMIFSGKGS WPHLSLEPIG ELAPVPIVGA ETIDLLNTGE KLFIFRNPKE
     PEISLHVPPR KKKNFLNAKK AMRALGMD
//
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