ID G3SJB2_GORGO Unreviewed; 405 AA.
AC G3SJB2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Sex hormone-binding globulin {ECO:0000256|ARBA:ARBA00040510};
DE AltName: Full=Sex steroid-binding protein {ECO:0000256|ARBA:ARBA00041855};
DE AltName: Full=Testis-specific androgen-binding protein {ECO:0000256|ARBA:ARBA00041528};
GN Name=SHBG {ECO:0000313|Ensembl:ENSGGOP00000028202.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000028202.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000028202.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000028202.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000028202.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions as an androgen transport protein, but may also be
CC involved in receptor mediated processes. Each dimer binds one molecule
CC of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and
CC 17-beta-estradiol. Regulates the plasma metabolic clearance rate of
CC steroid hormones by controlling their plasma concentration.
CC {ECO:0000256|ARBA:ARBA00037620}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00122}.
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DR EMBL; CABD030103507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004058546.1; XM_004058498.1.
DR AlphaFoldDB; G3SJB2; -.
DR STRING; 9593.ENSGGOP00000028202; -.
DR Ensembl; ENSGGOT00000025670.2; ENSGGOP00000028202.1; ENSGGOG00000025587.2.
DR eggNOG; KOG3927; Eukaryota.
DR GeneTree; ENSGT00940000154035; -.
DR HOGENOM; CLU_063172_0_0_1; -.
DR InParanoid; G3SJB2; -.
DR OMA; FPLMQIS; -.
DR TreeFam; TF334367; -.
DR Proteomes; UP000001519; Chromosome 17.
DR Bgee; ENSGGOG00000025587; Expressed in liver and 4 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005496; F:steroid binding; IBA:GO_Central.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24040; LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24040:SF3; SEX HORMONE-BINDING GLOBULIN; 1.
DR Pfam; PF00054; Laminin_G_1; 1.
DR SMART; SM00282; LamG; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Steroid-binding {ECO:0000256|ARBA:ARBA00022665}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..405
FT /note="Sex hormone-binding globulin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003454051"
FT DOMAIN 48..220
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
SQ SEQUENCE 405 AA; 44068 MW; 0D8CAB4F5D30DF52 CRC64;
MESRGPLATS RLLLSLLLLL LLLLRHTCQG WALRPVLPTQ SAHDPPAVHL SNGPGQEPIA
VMTFDLTKIT KTSSSFEVRT WDPEGVIFYG DTNPKDDWFM LGLRDGRPEI QLHNHWAQLT
VGAGPRLDDG RWHQVEVKME GDSVLLKVDG EEVLRLRQVS GPLTSKRHPI MRIALGGLLF
PASNLRLPLV PALDGCLRRD SWLDKQAEIS ASAPTSLRSC DVESNPGIFL PPGTQAEFNL
RDIPQPHAEP WAFSLDLGLK QAAGSGHLLA LGTPENPSWL SLHLQDQKVV LSSGSGPGLD
LPLVLGLPLQ LKLSMSRVVL GQGSKMEVLA LPPLGLAPLL NLWAKPQGRL FLGALPGEDS
STSFCLNGLW AQGQRLDVDQ ALNRSHEIWT HSCPQSPGNG TDTSH
//
