ID G3SJC5_GORGO Unreviewed; 274 AA.
AC G3SJC5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Neuromodulin {ECO:0000256|ARBA:ARBA00021591, ECO:0000256|RuleBase:RU368113};
DE AltName: Full=Axonal membrane protein GAP-43 {ECO:0000256|ARBA:ARBA00030597, ECO:0000256|RuleBase:RU368113};
DE AltName: Full=Growth-associated protein 43 {ECO:0000256|ARBA:ARBA00033250, ECO:0000256|RuleBase:RU368113};
GN Name=GAP43 {ECO:0000313|Ensembl:ENSGGOP00000028215.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000028215.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000028215.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000028215.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000028215.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: This protein is associated with nerve growth. It is a major
CC component of the motile 'growth cones' that form the tips of elongating
CC axons. Plays a role in axonal and dendritic filopodia induction.
CC {ECO:0000256|ARBA:ARBA00025215, ECO:0000256|RuleBase:RU368113}.
CC -!- SUBUNIT: Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1,
CC FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with
CC calmodulin. Binds calmodulin with a greater affinity in the absence of
CC Ca(2+) than in its presence. {ECO:0000256|RuleBase:RU368113}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU368113};
CC Peripheral membrane protein {ECO:0000256|RuleBase:RU368113};
CC Cytoplasmic side {ECO:0000256|RuleBase:RU368113}. Cell projection,
CC growth cone membrane {ECO:0000256|ARBA:ARBA00004503,
CC ECO:0000256|RuleBase:RU368113}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004503, ECO:0000256|RuleBase:RU368113};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004503,
CC ECO:0000256|RuleBase:RU368113}. Synapse {ECO:0000256|ARBA:ARBA00034103,
CC ECO:0000256|RuleBase:RU368113}. Cell projection, filopodium membrane
CC {ECO:0000256|ARBA:ARBA00004516, ECO:0000256|RuleBase:RU368113};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004516,
CC ECO:0000256|RuleBase:RU368113}. Perikaryon
CC {ECO:0000256|RuleBase:RU368113}. Cell projection, dendrite
CC {ECO:0000256|ARBA:ARBA00004279, ECO:0000256|RuleBase:RU368113}. Cell
CC projection, axon {ECO:0000256|RuleBase:RU368113}. Cytoplasm
CC {ECO:0000256|RuleBase:RU368113}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}. Note=Cytoplasmic surface of growth
CC cone and synaptic plasma membranes. {ECO:0000256|RuleBase:RU368113}.
CC -!- PTM: Palmitoylated. Palmitoylation is essential for plasma membrane
CC association. {ECO:0000256|RuleBase:RU368113}.
CC -!- SIMILARITY: Belongs to the neuromodulin family.
CC {ECO:0000256|ARBA:ARBA00005890, ECO:0000256|RuleBase:RU368113}.
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DR EMBL; CABD030023489; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030023490; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030023491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004036145.1; XM_004036097.2.
DR AlphaFoldDB; G3SJC5; -.
DR STRING; 9593.ENSGGOP00000028215; -.
DR Ensembl; ENSGGOT00000024062.2; ENSGGOP00000028215.1; ENSGGOG00000010216.3.
DR GeneID; 101137918; -.
DR CTD; 2596; -.
DR eggNOG; ENOG502RXWF; Eukaryota.
DR GeneTree; ENSGT00730000111265; -.
DR InParanoid; G3SJC5; -.
DR OMA; PNQTNDK; -.
DR OrthoDB; 4371674at2759; -.
DR TreeFam; TF333213; -.
DR Proteomes; UP000001519; Chromosome 3.
DR Bgee; ENSGGOG00000010216; Expressed in prefrontal cortex and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IEA:UniProtKB-SubCell.
DR GO; GO:0031527; C:filopodium membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032584; C:growth cone membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0014069; C:postsynaptic density; IBA:GO_Central.
DR GO; GO:0005516; F:calmodulin binding; IBA:GO_Central.
DR GO; GO:0035727; F:lysophosphatidic acid binding; IBA:GO_Central.
DR GO; GO:1901981; F:phosphatidylinositol phosphate binding; IBA:GO_Central.
DR GO; GO:0001786; F:phosphatidylserine binding; IBA:GO_Central.
DR GO; GO:0048708; P:astrocyte differentiation; IEA:Ensembl.
DR GO; GO:0016198; P:axon choice point recognition; IBA:GO_Central.
DR GO; GO:0031103; P:axon regeneration; IBA:GO_Central.
DR GO; GO:0045165; P:cell fate commitment; IEA:Ensembl.
DR GO; GO:0060019; P:radial glial cell differentiation; IEA:Ensembl.
DR GO; GO:0051489; P:regulation of filopodium assembly; IEA:Ensembl.
DR GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-UniRule.
DR GO; GO:0042246; P:tissue regeneration; IBA:GO_Central.
DR Gene3D; 1.20.5.190; -; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR001422; Neuromodulin.
DR InterPro; IPR017454; Neuromodulin_C.
DR InterPro; IPR018947; Neuromodulin_gap-junction_N.
DR InterPro; IPR033137; Neuromodulin_P_site.
DR PANTHER; PTHR10699; NEUROMODULIN; 1.
DR PANTHER; PTHR10699:SF15; NEUROMODULIN; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF06614; Neuromodulin; 1.
DR Pfam; PF10580; Neuromodulin_N; 1.
DR PRINTS; PR00215; NEUROMODULIN.
DR SMART; SM00015; IQ; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS00413; NEUROMODULIN_2; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860,
KW ECO:0000256|RuleBase:RU368113};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU368113};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273,
KW ECO:0000256|RuleBase:RU368113}; Cytoplasm {ECO:0000256|RuleBase:RU368113};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU368113};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782,
KW ECO:0000256|RuleBase:RU368113};
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604,
KW ECO:0000256|RuleBase:RU368113};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288, ECO:0000256|RuleBase:RU368113};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902,
KW ECO:0000256|RuleBase:RU368113}; Palmitate {ECO:0000256|RuleBase:RU368113};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553,
KW ECO:0000256|RuleBase:RU368113};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Synapse {ECO:0000256|ARBA:ARBA00023018, ECO:0000256|RuleBase:RU368113}.
FT DOMAIN 46..67
FT /note="Neuromodulin gap junction N-terminal"
FT /evidence="ECO:0000259|Pfam:PF10580"
FT DOMAIN 103..274
FT /note="Neuromodulin (GAP-43) C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06614"
FT REGION 51..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..114
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..191
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 274 AA; 28840 MW; C4EF3C6582B8FC86 CRC64;
MTKSCSELCH PALHFLPCLG GLRKNLQRAD RPSPYSLGFL TFWISRVEKN DDDQKIEQDG
IKPEDKAHKA ATKIQASFRG HITRKKLKGE KKDDVQAAEA EANKKDEAPV ADGVEKKGEG
TTTAEAAPTT GSKPDEPGKA GETPSEEKKG EGDAATEQAA PQAPASSEEK AGSAETESAT
KASTDNSPSS KAEDAPAKEE PKQADVPAAV TAAAATTPAA EDAAAKATAQ PPTETGESSQ
AEENIEAVDE TKPKESARQD EGKEEEPEAD REHA
//
