ID G3SM20_LOXAF Unreviewed; 396 AA.
AC G3SM20;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Rap guanine nucleotide exchange factor like 1 {ECO:0000313|Ensembl:ENSLAFP00000000511.3};
GN Name=RAPGEFL1 {ECO:0000313|Ensembl:ENSLAFP00000000511.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000000511.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000000511.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000000511.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000000511.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000000511.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3SM20; -.
DR Ensembl; ENSLAFT00000000607.3; ENSLAFP00000000511.3; ENSLAFG00000000607.3.
DR GeneTree; ENSGT00940000160144; -.
DR HOGENOM; CLU_028002_1_0_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF230; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR-LIKE 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 156..394
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 396 AA; 45473 MW; D8FD388DA8582AA6 CRC64;
LPDCQVLVDK IPEESQPPSK QVKPLFRHFR RIDSCLQTRV AFRGSDEIFC RVYMPDHSYV
TIRSRLSASV QDILGSVTEK LQYSEEPAGR EDSLILVAVA SSGEKVLLQP TEDCVFTTLG
INSHLFACTR DSYEALVPLP EEIQVSPGDT EIHRVEPEDV ANHLTAFHWE LFRCVHELEF
VDYVFHGERG RRETANLELL LQRCSEVTHW VATEVLLCES PGKRAQLLKK FIKIAAICKQ
NQDLLSFYAV VMGLDNAAVS RLRLTWEKLP GKFKNLYRKF ENLTDPCRNH KSYREVISKM
KPPVIPFVPL ILKDLTFLHE GSKTLVDGLV NIEKLHSVAE KVRTIRKYRS RPLYPGLDME
ASPHHLQTKA YVRQFQVIDN QNLLFELSYK LEANSQ
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