ID G3SMX5_LOXAF Unreviewed; 389 AA.
AC G3SMX5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=tRNA aspartic acid methyltransferase 1 {ECO:0000313|Ensembl:ENSLAFP00000000904.3};
GN Name=TRDMT1 {ECO:0000313|Ensembl:ENSLAFP00000000904.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000000904.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000000904.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000000904.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000000904.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000000904.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 9785.ENSLAFP00000000904; -.
DR Ensembl; ENSLAFT00000001075.3; ENSLAFP00000000904.3; ENSLAFG00000001075.3.
DR eggNOG; KOG0919; Eukaryota.
DR GeneTree; ENSGT00390000016416; -.
DR HOGENOM; CLU_049101_0_0_1; -.
DR InParanoid; G3SMX5; -.
DR OMA; HYAFKYA; -.
DR TreeFam; TF300024; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0016428; F:tRNA (cytidine-5-)-methyltransferase activity; IEA:Ensembl.
DR GO; GO:0030488; P:tRNA methylation; IEA:Ensembl.
DR GO; GO:0036416; P:tRNA stabilization; IEA:Ensembl.
DR Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR46098; TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR46098:SF1; TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE; 1.
DR Pfam; PF00145; DNA_methylase; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT ACT_SITE 79
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 389 AA; 44260 MW; 45A970F1859E29E6 CRC64;
AKPLNLDTKF IAVGEMNKNI TESCIPAQVV AAVDVNTVAN EVYKYNFPHT LLLAKAIEGI
TLEEFDRLSF NMILMSPPCQ PFTRIGLQGD KADPRTSSFL YILDILPRLK KLPKYILLEN
VKGFEVSSTR DMLIQTIENC GFQHQEFLLS PNSVGTIYLN IGYFLNGSFR SPWFLYQXPG
QILLEFPKIG SENPQKHAID AEKKTEEKKI EPNICLDGST QCSGKETILF KLETAKEIDR
KHQQNSDLSV QMLKDFLEHD IDINQYFLSP KLLQRYAFIL DIVKPTCRRS TCFTKGYGRF
IEGTGSVLQT AEDVQIESIY KSLSNLSEEE KITKLLMLKL RYFTPKEIAN LLGFPPEFGF
PENVTVKQRY CLLGNSLNVH IVAKLIKIL
//
