ID G3SP25_LOXAF Unreviewed; 1741 AA.
AC G3SP25;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Rho GTPase activating protein 32 {ECO:0000313|Ensembl:ENSLAFP00000001416.3};
GN Name=ARHGAP32 {ECO:0000313|Ensembl:ENSLAFP00000001416.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000001416.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000001416.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001416.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000001416.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001416.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 9785.ENSLAFP00000001416; -.
DR Ensembl; ENSLAFT00000001695.3; ENSLAFP00000001416.3; ENSLAFG00000001694.3.
DR eggNOG; KOG1449; Eukaryota.
DR eggNOG; KOG3564; Eukaryota.
DR GeneTree; ENSGT00940000154313; -.
DR HOGENOM; CLU_002754_0_0_1; -.
DR InParanoid; G3SP25; -.
DR OMA; IIQVTDC; -.
DR TreeFam; TF351451; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0005938; C:cell cortex; IEA:Ensembl.
DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04384; RhoGAP_CdGAP; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15729; CDC42 GTPASE-ACTIVATING PROTEIN; 1.
DR PANTHER; PTHR15729:SF13; RHO GTPASE-ACTIVATING PROTEIN 32; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 23..218
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 348..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 471..509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 580..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..688
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 979..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1489..1514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1530..1651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 580..611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 758..797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1588..1623
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1741 AA; 189803 MW; 2DD607E5A9B4CF41 CRC64;
MKSRPTKQKL KQRGILKERV FGCDLGEHLL NSGFEVPQVL QSCTAFIERY GIVDGIYRLS
GVASNIQRLR HEFDSEHVPD LTKEPYVQDI HSVGSLCKLY FRELPNPLLT YQLYEKFSDA
VSAATDEERL IKIHDVIQQL PPPHYRTLEF LMRHLSLLAD YCSITNMHAK NLAIVWAPNL
LRSKQIESAC FSGTAAFMEV RIQSVVVEFI LNHVDVLFSG KISAVIQEGA ASLSRPKSLL
VSSPSTKLLT LEEAQARTQA QVNSPIVTEN KYIEVGEGPA ALQGKFHTII EFPLERKRPQ
NKMKKSPVGS WRSFFNLGKS SSVSKRKLQR NESEPSEMKA MALKGARAEG TLRSAKSEES
LTSLHAADGD SKLFRPRRPR SSSDALSASF NGEMLGNRCN SYDNLPHDNE SEEEVGALHI
PALLSPHSAE DVDLSPPDIG VASLDFDPMS FQCSPPKAGS ECLESDNSFL DSLGYSKDKP
NTNKKDADGG GSQSQTPGST ASSEPVSPLQ EKLSPFFTLD LSPAEDKSSK PSSFTEKVVY
AFSPKIGRKL SKSPSLNISE PISVTLPPRV SEVIGAVSDT AAQNASSPAQ NKNMEDSDVT
NRSPTQAVKT KTSEREAQEG CEPEVQTLDQ VVAVDEVALP EREEQALLST QSKAVPAGQA
QTGAVTHDPP QDPVPVSSVS LIPPPPPPKN VARMLALALA ESAQQASTQS LKRPGNSQAG
YADYGDMAVA VAEDTLPSSY PSVTLDKACH HTDTPVEQFH LHNNTPGDCG QPTPDPTASG
GHTHSNAAES GEQLHQADSP GDQPHRTCLS GDPEQAQIPA VPSADSEKPN EHTCFPEDQP
GKPSVPAVSS VDQDPSHLHF CSGDQPPPHP GARVDRPYHA SELADSSPTP NLPRDKIYPP
SGSPEENTST ATLAYVTAVP TTAEVNIRAA SWNAVEQPPA TSLAVATLQR AHRAGRPLPP
PPSQRPAEQL PTLGQVQAPA SIGLNNPHKV PGVAPAPEKP PEPRAADEPV SVFVSDGSAS
AQCTVSVPAV HPGLPEKSRE GTRAPLLHLQ AESVPLHPSC GFAAPMPPTR TMESKIATAV
HASSADASSS SNYHSFVTAS SASLDDGLPV QLPIPQRKHA SQKTAYSSFA RPDVTIEPFG
PENCLHFNMT PNCQYRPQSV PPHHNKLEQH QSYGARSEPS VSVGPRYNTY MAPGRSVSGH
HAKPCSRLEY VSPLSSSVRN ACYPEDIPAY PTIRRVQSLH APPSSMIRSV PISRTEVPPD
DEPAYCPRPL YQYKPYQSSQ GRSDYHVTQL QPYFENGRVH YRYSPYSSSS SYYSPSGALC
DVDAYGTVQL RPVHRLPNRD FAFYNSRLQG KNLYSYPALP TRPRANVIGY FSGNDHNVVN
MPPATDIKHT YASWDLEDME KYRMQSIRRE SRARQKVKGP VMSQYDNMTP AVQDDLGGLY
VVHLRSKSDP GKTGLLSVAE GKEGRYPAKA MSPEGDDRFY RKHPEPELER AHHHGGYGNG
QPEKPSLPQK QSSLRNRKIH DMGCNLPEHR AHQEASHRQL CESKNGPPHP QGAGQLDYGS
KGIPDPSEPV SYHSSGGKFV PSGQESLRLN HKEVRLSKEL ERPRTRQPSA PEKYSRDCYK
EEEPLVQAVV PPPKPERSHS LKLHHPPSME RDPGVLYQYQ MPSKRQSGAT VLSQYDNLEV
YHSLPQHPRG VFGGGGGGVG TYVPSGFLHP QNRTYATALG QGAFLPTELS LQHPETQIPA
E
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