ID G3SPI8_LOXAF Unreviewed; 174 AA.
AC G3SPI8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Acidic leucine-rich nuclear phosphoprotein 32 family member {ECO:0000256|RuleBase:RU369103};
GN Name=ANP32B {ECO:0000313|Ensembl:ENSLAFP00000001626.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000001626.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000001626.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001626.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000001626.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001626.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Multifunctional protein that is involved in the regulation of
CC many processes. {ECO:0000256|RuleBase:RU369103}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369103}.
CC -!- SIMILARITY: Belongs to the ANP32 family.
CC {ECO:0000256|ARBA:ARBA00025777, ECO:0000256|RuleBase:RU369103}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3SPI8; -.
DR STRING; 9785.ENSLAFP00000001626; -.
DR Ensembl; ENSLAFT00000001943.2; ENSLAFP00000001626.2; ENSLAFG00000001943.2.
DR eggNOG; KOG2739; Eukaryota.
DR GeneTree; ENSGT00950000182907; -.
DR HOGENOM; CLU_063314_3_1_1; -.
DR InParanoid; G3SPI8; -.
DR OMA; NCEDREA; -.
DR TreeFam; TF317206; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR GO; GO:0070063; F:RNA polymerase binding; IEA:Ensembl.
DR GO; GO:0048839; P:inner ear development; IEA:Ensembl.
DR GO; GO:0045596; P:negative regulation of cell differentiation; IEA:Ensembl.
DR GO; GO:0006334; P:nucleosome assembly; IEA:Ensembl.
DR GO; GO:0046827; P:positive regulation of protein export from nucleus; IEA:Ensembl.
DR GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
DR GO; GO:0001944; P:vasculature development; IEA:Ensembl.
DR GO; GO:0021591; P:ventricular system development; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR045081; AN32.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR003603; U2A'_phosphoprotein32A_C.
DR PANTHER; PTHR11375; ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32; 1.
DR PANTHER; PTHR11375:SF2; ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER B; 1.
DR Pfam; PF14580; LRR_9; 1.
DR SMART; SM00446; LRRcap; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS51450; LRR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614,
KW ECO:0000256|RuleBase:RU369103}; Nucleus {ECO:0000256|RuleBase:RU369103};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 128..146
FT /note="U2A'/phosphoprotein 32 family A C-terminal"
FT /evidence="ECO:0000259|SMART:SM00446"
FT REGION 149..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..174
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 174 AA; 19703 MW; B11751A043148A9B CRC64;
LTLRKKIHVK IKIRDGKYVR ELVLDNCKSN DGKIEGLTAE FVNLEFLSLI NVGLISVSNL
PKLPKLKKLE LSDNRICGGL DMLAEKLPNL THLNLSGNKL KDISTLEPLK KLECLKSLDL
FNCEVTNLND YRESVFKLLP QLTYLDGYDR EDREAPDSDA EVDGVDEEEE DEGE
//
