ID G3SPP1_LOXAF Unreviewed; 463 AA.
AC G3SPP1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Solute carrier family 39 member 8 {ECO:0000313|Ensembl:ENSLAFP00000001698.2};
GN Name=SLC39A8 {ECO:0000313|Ensembl:ENSLAFP00000001698.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000001698.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000001698.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001698.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000001698.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001698.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
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DR AlphaFoldDB; G3SPP1; -.
DR STRING; 9785.ENSLAFP00000001698; -.
DR Ensembl; ENSLAFT00000002028.2; ENSLAFP00000001698.2; ENSLAFG00000002028.2.
DR eggNOG; KOG2693; Eukaryota.
DR GeneTree; ENSGT00940000158926; -.
DR HOGENOM; CLU_015114_13_0_1; -.
DR InParanoid; G3SPP1; -.
DR OMA; ITMFAGE; -.
DR TreeFam; TF318470; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0140412; F:zinc:bicarbonate symporter activity; IEA:Ensembl.
DR GO; GO:0006525; P:arginine metabolic process; IEA:Ensembl.
DR GO; GO:0070574; P:cadmium ion transmembrane transport; IEA:Ensembl.
DR GO; GO:1990079; P:cartilage homeostasis; IEA:Ensembl.
DR GO; GO:0098849; P:cellular detoxification of cadmium ion; IEA:Ensembl.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0030026; P:intracellular manganese ion homeostasis; IEA:Ensembl.
DR GO; GO:0006882; P:intracellular zinc ion homeostasis; IEA:Ensembl.
DR GO; GO:0098711; P:iron ion import across plasma membrane; IEA:Ensembl.
DR GO; GO:0061757; P:leukocyte adhesion to arterial endothelial cell; IEA:Ensembl.
DR GO; GO:0015694; P:mercury ion transport; IEA:Ensembl.
DR GO; GO:1990540; P:mitochondrial manganese ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0043124; P:negative regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0050728; P:negative regulation of inflammatory response; IEA:Ensembl.
DR GO; GO:0097080; P:plasma membrane selenite transport; IEA:Ensembl.
DR GO; GO:0006487; P:protein N-linked glycosylation; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR GO; GO:0071578; P:zinc ion import across plasma membrane; IEA:Ensembl.
DR InterPro; IPR003689; ZIP.
DR PANTHER; PTHR12191:SF2; METAL CATION SYMPORTER ZIP8; 1.
DR PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR Pfam; PF02535; Zip; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..463
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003454270"
FT TRANSMEM 130..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 463 AA; 49937 MW; B33A21D0176C1993 CRC64;
MAPGRAVAGL LLLAAAGLGE AAAGPGLAFS EDVLSVFGAN RSLSVPQLGR LLELLGAAPV
KGAPEPGLLH FNQCLSAEEI FYLHGFSNAT QITSSNLSTI CPAVLQQLSL HPCEARPKRN
TKSSLSEATV WGYGFLSVTI INLASLLGLV LTPLIKKPYF PKVLTYFVGL AIGTLFSNAI
FQLIPEAFGF DPKVDNYVEK AAAVFGGFYI FFFVERMLKM LLKTYGQNNH THFASDDFGP
PQEKTHQPKT LPAINGVTCY ANPAVTEPNG HIHFDNVDVV SLQDEKRESS SCTCLKGPKL
SEIGTIAWMI TLSDALHNFI DGLAIGASFT LSLFQGLSTS IAILCEEFPH ELGDFVILLN
AGMSTRQALL FNFLSACSCY VGLAFGILVG NNFAPNIIFA LAGGMFLYIS LADMFPEMND
MLREKVTGRK TDFTFFMIQN AGMLTGFIAI LLITLFAGDI ELE
//
