UniProt: G3SPU8

Database: UniProt
Entry: G3SPU8_LOXAF

LinkDB:  G3SPU8_LOXAF 
Original site:  G3SPU8_LOXAF

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Ontology (4)   
   GO (4)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (11)   
   InterPro (6)   
   Pfam (2)   
   PROSITE (2)   
   SMART (1)   
All databases (21)   

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ID   G3SPU8_LOXAF            Unreviewed;       367 AA.
AC   G3SPU8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   RecName: Full=Left-right determination factor {ECO:0000256|PIRNR:PIRNR037402};
GN   Name=LOC100662668 {ECO:0000313|Ensembl:ENSLAFP00000001763.2};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000001763.2, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000001763.2, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001763.2,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000001763.2}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000001763.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|PIRNR:PIRNR037402}.
CC   -!- SIMILARITY: Belongs to the TGF-beta family.
CC       {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|PIRNR:PIRNR037402,
CC       ECO:0000256|RuleBase:RU000354}.
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DR   RefSeq; XP_003411078.1; XM_003411030.1.
DR   AlphaFoldDB; G3SPU8; -.
DR   STRING; 9785.ENSLAFP00000001763; -.
DR   Ensembl; ENSLAFT00000002108.2; ENSLAFP00000001763.2; ENSLAFG00000002109.2.
DR   GeneID; 100662668; -.
DR   KEGG; lav:100662668; -.
DR   eggNOG; KOG3900; Eukaryota.
DR   GeneTree; ENSGT00390000010056; -.
DR   HOGENOM; CLU_064098_0_0_1; -.
DR   InParanoid; G3SPU8; -.
DR   OMA; SCAWDGV; -.
DR   OrthoDB; 5391376at2759; -.
DR   TreeFam; TF106462; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005160; F:transforming growth factor beta receptor binding; IEA:InterPro.
DR   CDD; cd13758; TGF_beta_LEFTY1_2; 1.
DR   Gene3D; 2.60.120.970; -; 1.
DR   Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR003942; LRDF.
DR   InterPro; IPR001839; TGF-b_C.
DR   InterPro; IPR001111; TGF-b_propeptide.
DR   InterPro; IPR015615; TGF-beta-rel.
DR   InterPro; IPR017948; TGFb_CS.
DR   PANTHER; PTHR11848:SF226; LEFT-RIGHT DETERMINATION FACTOR; 1.
DR   PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR   Pfam; PF00019; TGF_beta; 1.
DR   Pfam; PF00688; TGFb_propeptide; 1.
DR   PIRSF; PIRSF037402; TGFb4; 1.
DR   PRINTS; PR01427; TGFBETA4.
DR   SMART; SM00204; TGFB; 1.
DR   SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR   PROSITE; PS00250; TGF_BETA_1; 1.
DR   PROSITE; PS51362; TGF_BETA_2; 1.
PE   3: Inferred from homology;
KW   Cytokine {ECO:0000256|PIRNR:PIRNR037402};
KW   Developmental protein {ECO:0000256|PIRNR:PIRNR037402};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW   ECO:0000256|PIRNR:PIRNR037402};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525, ECO:0000256|PIRNR:PIRNR037402};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..367
FT                   /note="Left-right determination factor"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003454033"
FT   DOMAIN          241..355
FT                   /note="TGF-beta family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS51362"
SQ   SEQUENCE   367 AA;  41101 MW;  F70F613310A2C29F CRC64;
     MWPLWLCWAL WVLPLVGPAA ALTEEQVRAS LLQQLHLSQV PVLDKADVED LVIPAHVRAQ
     YVALLHRSHG VLSRGKRFSQ KFREVAGRLL ASEASTHLLV FRMEQRLPPD SELVQAVLRL
     FQEPVPKAAL RRHERLFQRS ARARVTVEWL RVRDDGTNRT SLVDSRLVSL HESGWKAFDV
     TEAVSLWQQL SRPRQPLVLQ VSVQREHLGP LASDAHKLVR FASQVAGDAG QREPQLELHT
     LDLKAYGAQG DCDPEAPVAE GARCCRQETY IDLQGMKWAE NWVLEPPGFL AYECVGACQQ
     PQESLTFQWP FLGPRQCISS ETASLPMIVG IKEGGRARPQ VVSLPNLRVQ KCSCTSDGVP
     VPRELGP
//

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