ID G3SRE3_LOXAF Unreviewed; 360 AA.
AC G3SRE3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Homer scaffold protein 3 {ECO:0000313|Ensembl:ENSLAFP00000002447.2};
GN Name=HOMER3 {ECO:0000313|Ensembl:ENSLAFP00000002447.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000002447.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000002447.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000002447.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000002447.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000002447.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Postsynaptic density {ECO:0000256|ARBA:ARBA00034105}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the Homer family.
CC {ECO:0000256|ARBA:ARBA00023606}.
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DR AlphaFoldDB; G3SRE3; -.
DR STRING; 9785.ENSLAFP00000002447; -.
DR Ensembl; ENSLAFT00000002936.2; ENSLAFP00000002447.2; ENSLAFG00000002936.2.
DR eggNOG; ENOG502R3T0; Eukaryota.
DR GeneTree; ENSGT00940000158081; -.
DR HOGENOM; CLU_033940_0_0_1; -.
DR InParanoid; G3SRE3; -.
DR OMA; QRCGRWE; -.
DR TreeFam; TF325627; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0045178; C:basal part of cell; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR GO; GO:0035256; F:G protein-coupled glutamate receptor binding; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IEA:InterPro.
DR GO; GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; IEA:Ensembl.
DR GO; GO:0032703; P:negative regulation of interleukin-2 production; IEA:Ensembl.
DR CDD; cd01206; EVH1_Homer_Vesl; 1.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR045027; Homer.
DR InterPro; IPR044100; Homer_EVH1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR10918; HOMER; 1.
DR PANTHER; PTHR10918:SF4; HOMER PROTEIN HOMOLOG 3; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50229; WH1; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 2..114
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT REGION 115..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 273..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..298
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 360 AA; 39961 MW; F7DCA02A5E47A593 CRC64;
MPSSSREQPI FSTRAHVFQI DPATKRNWIP AGKHALTVSY FYDATRNVYR IISIGGAKAI
INSTVTPNMT FTKTSQKFGQ WADSRANTVY GLGFASEQHL TQFAEKFQEV KEAARLAREK
SQDGGELTSP ALGLASHQMP PNSLVSANGP PSDEKLFRSQ SADAPGPAER ERLKKMLSEG
SVGEVQWEAE FFALQDSNNK LAGALREANA AAAQWRQQLE AQRVEAERLR QRVAELEAQA
AAEQPTVGEK EPGQSLEQLE ALVQTKDQEI QTLKSQTGGP RETPDAAERE ETQQKVQDLE
TRNAELERQL RVSEHSLEEA RAERERARAE VVRATQLLDV KLFELSELRE GLARLAEGTP
//
