ID G3SRT3_LOXAF Unreviewed; 343 AA.
AC G3SRT3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Ileal sodium/bile acid cotransporter {ECO:0000256|ARBA:ARBA00013351};
DE AltName: Full=Apical sodium-dependent bile acid transporter {ECO:0000256|ARBA:ARBA00032438};
DE AltName: Full=Ileal Na(+)/bile acid cotransporter {ECO:0000256|ARBA:ARBA00033223};
DE AltName: Full=Ileal sodium-dependent bile acid transporter {ECO:0000256|ARBA:ARBA00030792};
DE AltName: Full=Na(+)-dependent ileal bile acid transporter {ECO:0000256|ARBA:ARBA00033014};
DE AltName: Full=Solute carrier family 10 member 2 {ECO:0000256|ARBA:ARBA00031381};
GN Name=SLC10A2 {ECO:0000313|Ensembl:ENSLAFP00000002622.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000002622.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000002622.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000002622.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000002622.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000002622.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + tauro-beta-muricholate(out) = 2 Na(+)(in) +
CC tauro-beta-muricholate(in); Xref=Rhea:RHEA:72179, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:133064; Evidence={ECO:0000256|ARBA:ARBA00034255};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + tauroallocholate(out) = 2 Na(+)(in) +
CC tauroallocholate(in); Xref=Rhea:RHEA:51840, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:191406; Evidence={ECO:0000256|ARBA:ARBA00034234};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + taurochenodeoxycholate(out) = 2 Na(+)(in) +
CC taurochenodeoxycholate(in); Xref=Rhea:RHEA:71923, ChEBI:CHEBI:9407,
CC ChEBI:CHEBI:29101; Evidence={ECO:0000256|ARBA:ARBA00034224};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + taurocholate(out) = 2 Na(+)(in) +
CC taurocholate(in); Xref=Rhea:RHEA:71875, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:36257; Evidence={ECO:0000256|ARBA:ARBA00034239};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + taurodeoxycholate(out) = 2 Na(+)(in) +
CC taurodeoxycholate(in); Xref=Rhea:RHEA:72087, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:36261; Evidence={ECO:0000256|ARBA:ARBA00034280};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + tauronorcholate(out) = 2 Na(+)(in) +
CC tauronorcholate(in); Xref=Rhea:RHEA:71915, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:191405; Evidence={ECO:0000256|ARBA:ARBA00034291};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2 Na(+)(out) + tauroursodeoxycholate(out) = 2 Na(+)(in) +
CC tauroursodeoxycholate(in); Xref=Rhea:RHEA:71927, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:132028; Evidence={ECO:0000256|ARBA:ARBA00034230};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholate(out) + 2 Na(+)(out) = cholate(in) + 2 Na(+)(in);
CC Xref=Rhea:RHEA:71911, ChEBI:CHEBI:29101, ChEBI:CHEBI:29747;
CC Evidence={ECO:0000256|ARBA:ARBA00034231};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glycocholate(out) + 2 Na(+)(out) = glycocholate(in) + 2
CC Na(+)(in); Xref=Rhea:RHEA:71935, ChEBI:CHEBI:29101,
CC ChEBI:CHEBI:29746; Evidence={ECO:0000256|ARBA:ARBA00034215};
CC -!- SUBUNIT: Monomer and homodimer. {ECO:0000256|ARBA:ARBA00011407}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the bile acid:sodium symporter (BASS) (TC
CC 2.A.28) family. {ECO:0000256|ARBA:ARBA00006528}.
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DR RefSeq; XP_003414020.2; XM_003413972.2.
DR AlphaFoldDB; G3SRT3; -.
DR STRING; 9785.ENSLAFP00000002622; -.
DR Ensembl; ENSLAFT00000003157.2; ENSLAFP00000002622.2; ENSLAFG00000003157.2.
DR GeneID; 100677189; -.
DR KEGG; lav:100677189; -.
DR CTD; 6555; -.
DR eggNOG; KOG2718; Eukaryota.
DR GeneTree; ENSGT00950000182808; -.
DR HOGENOM; CLU_034788_7_5_1; -.
DR InParanoid; G3SRT3; -.
DR OMA; AHYVIMP; -.
DR OrthoDB; 3035577at2759; -.
DR TreeFam; TF315811; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR InterPro; IPR004710; Bilac:Na_transpt.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR NCBIfam; TIGR00841; bass; 1.
DR PANTHER; PTHR10361:SF19; ILEAL SODIUM_BILE ACID COTRANSPORTER; 1.
DR PANTHER; PTHR10361; SODIUM-BILE ACID COTRANSPORTER; 1.
DR Pfam; PF01758; SBF; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00023055}.
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 68..90
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..248
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 343 AA; 37439 MW; DAD0E6ABC6F6FAF5 CRC64;
MNNLSSCLPN ATICDGASCV LAETNSNYIL NVVLSAILTI LLALVMFSMG CNVEVKKFLG
HIKQPWGIFV GFLCQFGIMP LTGFILSVAF NILPIQAVVV LIIGCCPGGT ASNILAYWVD
GDMDLSISMT TCSTLLALGM MPLCLFLYTK MWAEVGTIVI PYDSIGISLV ALLIPVSVGM
YVNHKWPQKA KLILKVGSIT GAILIVLIAV VGGILYQSSW IISPQMWIIG TIFPVAGYLL
GFFLARIAGL PWYRCRTVAL ETGMQNTQLC STIVQLSFTP EQLTHIFTFP LIYTIFQVVF
AALLVGFYVA YKKCHGKNKA EFPESRDNET MSDSSLYKMN GGF
//
