ID   G3SS30_LOXAF            Unreviewed;       418 AA.
AC   G3SS30;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=Potassium channel tetramerization domain containing 18 {ECO:0000313|Ensembl:ENSLAFP00000002726.2};
GN   Name=KCTD18 {ECO:0000313|Ensembl:ENSLAFP00000002726.2};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000002726.2, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000002726.2, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000002726.2,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000002726.2}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000002726.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; G3SS30; -.
DR   STRING; 9785.ENSLAFP00000002726; -.
DR   Ensembl; ENSLAFT00000003280.2; ENSLAFP00000002726.2; ENSLAFG00000003281.2.
DR   eggNOG; KOG2723; Eukaryota.
DR   GeneTree; ENSGT00530000064234; -.
DR   HOGENOM; CLU_052824_0_0_1; -.
DR   InParanoid; G3SS30; -.
DR   OMA; CKAGPKP; -.
DR   TreeFam; TF315332; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   CDD; cd18372; BTB_POZ_KCTD18; 1.
DR   InterPro; IPR045704; KCTD18_C.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   PANTHER; PTHR14499:SF4; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD18; 1.
DR   PANTHER; PTHR14499; POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   Pfam; PF19321; KCTD18_C; 1.
DR   SUPFAM; SSF54695; POZ domain; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT   DOMAIN          16..100
FT                   /note="Potassium channel tetramerisation-type BTB"
FT                   /evidence="ECO:0000259|Pfam:PF02214"
FT   DOMAIN          116..417
FT                   /note="BTB/POZ"
FT                   /evidence="ECO:0000259|Pfam:PF19321"
FT   REGION          293..418
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        293..345
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        380..418
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   418 AA;  46228 MW;  FBBEDCCC11E240E2 CRC64;
     GAMEGHKAEE EVLDILRLNV GGCIYTARRE SLCRFKDSML ASMFSGRFSL KTDESGACVI
     DRDGHLFKYL LDYLHGEVQI PSDEQTRAAL QEEADYFGIP YPYSLSDHLA NEMETYSLRS
     NIELKKALTD FCDSYGLVCN KPTVWVLHYL NTSGASCESR VIGVYATKTD GTDAIDKQLG
     GRIHSKSIFK REAGNNVQYI WSYYSVAELK KMMDAFDAWE GKGVSYWRVP HELIECWTLE
     EQPLLGSLRH MAPIRKRRLV TFSEEEESVN FKTGPKPVRF LGPSTSTQIK VKNSASVRVS
     PARAPQTSTR VTANQPHSSS VPSEATSAVG TRACRQPQAS WGTRSAENGA PHPPTAKVLL
     SDKKSTSNRV IKLKRTPLCA SVPSQPTSAA VNRSLSPELP AHEASSSTPV RTENGNDE
//