ID G3SSA4_LOXAF Unreviewed; 554 AA.
AC G3SSA4;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Keratin 75 {ECO:0000313|Ensembl:ENSLAFP00000002820.3};
GN Name=KRT75 {ECO:0000313|Ensembl:ENSLAFP00000002820.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000002820.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000002820.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000002820.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000002820.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000002820.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3SSA4; -.
DR STRING; 9785.ENSLAFP00000002820; -.
DR Ensembl; ENSLAFT00000003390.3; ENSLAFP00000002820.3; ENSLAFG00000032159.1.
DR eggNOG; ENOG502RTYA; Eukaryota.
DR GeneTree; ENSGT00940000155862; -.
DR InParanoid; G3SSA4; -.
DR TreeFam; TF317854; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0001533; C:cornified envelope; IEA:Ensembl.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF13; KERATIN, TYPE II CYTOSKELETAL 75; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 1.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 3.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754};
KW Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 150..463
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 526..554
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 154..260
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 361..441
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 554 AA; 60068 MW; A2C08F9F7FC80117 CRC64;
MSLQSSITFQ AGSRRGFSTT SATTPAAQHS HFSSISVTHS SGGNGGLGRI SSAGAGFGSR
SLYNLGGTKR TSVGGCSSSF RSSFGSRAGS KFGFASSSGF GYGGGVGGGF GSPGFPVPSD
GIQVVTVTQS LLSPLYLQID PTIQRVQKEE REQIKTLNNK FASFIDKVRF LEQQNKVLET
KWNLLQEQGS RTVRQNLEPL FDAYTSELRR QVDRITTERG RLEAELRNMQ DIVEDFKVRY
EDEINKRTAA ENEFVALKKD VDGAYMNKVE LEARVNSLTD EINFFRMLYE AELSQMQTQV
SDTSVVLSMD NNRSLDLDSI IAEVKAQYED IANRSRAEAE SWYQTKYKEL QVTAGRHDND
LRNTKHEISE VNRVIQRLRA EIDSVKKQCA SLQTAIADAE QRGELALKDA LAKLVDLEEA
LQKAKQDMAR LLREYQELMN VKLALDVESA TYRKLLEGKE SRLSGEGVSP VNISVVTNTV
PRGYGSGSGS GIGGGSLGLS GGSSYSFTTS GGHSVGAGLG GSAFSASSSR GLGGSGPSVK
FVSTTPSSRK NYKH
//
