ID G3SSW0_LOXAF Unreviewed; 642 AA.
AC G3SSW0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Sorting nexin 25 {ECO:0000313|Ensembl:ENSLAFP00000003072.4};
GN Name=SNX25 {ECO:0000313|Ensembl:ENSLAFP00000003072.4};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000003072.4, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000003072.4, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000003072.4,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000003072.4}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000003072.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3SSW0; -.
DR STRING; 9785.ENSLAFP00000003072; -.
DR Ensembl; ENSLAFT00000003690.4; ENSLAFP00000003072.4; ENSLAFG00000003687.4.
DR eggNOG; KOG2101; Eukaryota.
DR GeneTree; ENSGT00950000182856; -.
DR HOGENOM; CLU_005899_0_1_1; -.
DR InParanoid; G3SSW0; -.
DR OMA; LYALMGE; -.
DR TreeFam; TF324055; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:Ensembl.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd06878; PX_SNX25; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR037899; SNX25_PX.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF29; SORTING NEXIN-25; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 88..202
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 309..429
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 208..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 642 AA; 74530 MW; E66298DC12179D0E CRC64;
RYQIVVEIIQ ATTISSFPQL KRHKGKETAA MKADLLRARN MKRYINQLTV AKKQCEKRIR
ILGGPAYDQQ EDGALDEGEG PQSQKILQFE DIMANACYRE HFRIYVERMD RRALISFWES
VERLKTANKN EIPQLVGEIY QNFFVENKEI PVEKSLYKEI QQCLVGNKGI EVFCRIQGDV
YETLKDRYYP SFIVSDLYEK LMTKEEEKHG PRLISDKDEV GQGGEAGEES VDEGTRRMNE
QASFAVNKLR ELNDKLEYKR QALISIQNAP KPDKKIVSKL KDEIILMEKE RTELQLHMAR
TDWWCENLGM WKASVTSGEV TEENGEQMPC YFVTVSLQEA GGVGAKNWTV PRRLSEFQNL
HRKLSECFPS LKKVQLPSLS KLPFKSVDQK FMEKSKNQLN KFLQNLLSDE RLCQSEALYA
FLSPSPDYLK VIDVQGKKPT FSLASFLERL PRDFFSHQEE ETEEDSDLSD YGDDMDGRKD
ALAEPCFMLI GEIFELRGMF KWVRRTLIAL VQVTFGRTIN KRQIRDTVNW IFSEQMLVYY
ISVFRDAFWP NGKLAPPTTI RNKQQSPETK QRAQQKLLEN IPDMLQSLVG QQNARHGIIK
IFNALQETRA NKHLLYVLME LLLIELCPEL RTHLDQMKTG PV
//
