GenomeNet

Database: UniProt
Entry: G3STS1_LOXAF
LinkDB: G3STS1_LOXAF
Original site: G3STS1_LOXAF 
ID   G3STS1_LOXAF            Unreviewed;       850 AA.
AC   G3STS1;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   05-JUN-2019, entry version 45.
DE   RecName: Full=Diacylglycerol kinase {ECO:0000256|RuleBase:RU361128};
DE            Short=DAG kinase {ECO:0000256|RuleBase:RU361128};
DE            EC=2.7.1.107 {ECO:0000256|RuleBase:RU361128};
GN   Name=DGKQ {ECO:0000313|Ensembl:ENSLAFP00000003477};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000003477};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000003477}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000003477};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000003477}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000003477};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-
CC         3-phosphate + ADP + H(+); Xref=Rhea:RHEA:10272,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:58608, ChEBI:CHEBI:456216; EC=2.7.1.107;
CC         Evidence={ECO:0000256|RuleBase:RU361128};
CC   -!- SIMILARITY: Belongs to the eukaryotic diacylglycerol kinase
CC       family. {ECO:0000256|RuleBase:RU361128}.
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DR   STRING; 9785.ENSLAFP00000003477; -.
DR   Ensembl; ENSLAFT00000004170; ENSLAFP00000003477; ENSLAFG00000004169.
DR   eggNOG; KOG1169; Eukaryota.
DR   eggNOG; ENOG410XQVB; LUCA.
DR   GeneTree; ENSGT00940000159492; -.
DR   InParanoid; G3STS1; -.
DR   OMA; CEVCNFM; -.
DR   TreeFam; TF312817; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005856; C:cytoskeleton; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005768; C:endosome; IEA:Ensembl.
DR   GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0098794; C:postsynapse; IEA:Ensembl.
DR   GO; GO:0098793; C:presynapse; IEA:Ensembl.
DR   GO; GO:0012506; C:vesicle membrane; IEA:Ensembl.
DR   GO; GO:0033613; F:activating transcription factor binding; IEA:Ensembl.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004143; F:diacylglycerol kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019900; F:kinase binding; IEA:Ensembl.
DR   GO; GO:0003951; F:NAD+ kinase activity; IEA:InterPro.
DR   GO; GO:0043274; F:phospholipase binding; IEA:Ensembl.
DR   GO; GO:0030297; F:transmembrane receptor protein tyrosine kinase activator activity; IEA:Ensembl.
DR   GO; GO:0019933; P:cAMP-mediated signaling; IEA:Ensembl.
DR   GO; GO:0046339; P:diacylglycerol metabolic process; IEA:Ensembl.
DR   GO; GO:0046834; P:lipid phosphorylation; IEA:Ensembl.
DR   GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IEA:Ensembl.
DR   GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl.
DR   GO; GO:0006654; P:phosphatidic acid biosynthetic process; IEA:Ensembl.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   GO; GO:0070528; P:protein kinase C signaling; IEA:Ensembl.
DR   GO; GO:0007205; P:protein kinase C-activating G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0090181; P:regulation of cholesterol metabolic process; IEA:Ensembl.
DR   GO; GO:2000064; P:regulation of cortisol biosynthetic process; IEA:Ensembl.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0006111; P:regulation of gluconeogenesis; IEA:Ensembl.
DR   GO; GO:2000182; P:regulation of progesterone biosynthetic process; IEA:Ensembl.
DR   GO; GO:1900242; P:regulation of synaptic vesicle endocytosis; IEA:Ensembl.
DR   GO; GO:1903432; P:regulation of TORC1 signaling; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0033198; P:response to ATP; IEA:Ensembl.
DR   GO; GO:0051591; P:response to cAMP; IEA:Ensembl.
DR   GO; GO:0070493; P:thrombin-activated receptor signaling pathway; IEA:Ensembl.
DR   CDD; cd00029; C1; 1.
DR   Gene3D; 3.40.50.10330; -; 1.
DR   InterPro; IPR017438; ATP-NAD_kinase_N.
DR   InterPro; IPR037607; DGK.
DR   InterPro; IPR000756; Diacylglycerol_kin_accessory.
DR   InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR   InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR   InterPro; IPR002219; PE/DAG-bd.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR11255; PTHR11255; 1.
DR   Pfam; PF00130; C1_1; 1.
DR   Pfam; PF00609; DAGK_acc; 1.
DR   Pfam; PF00781; DAGK_cat; 1.
DR   Pfam; PF00788; RA; 1.
DR   SMART; SM00109; C1; 2.
DR   SMART; SM00045; DAGKa; 1.
DR   SMART; SM00046; DAGKc; 1.
DR   SMART; SM00314; RA; 1.
DR   SUPFAM; SSF111331; SSF111331; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50146; DAGK; 1.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR   PROSITE; PS50081; ZF_DAG_PE_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU361128};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Kinase {ECO:0000256|RuleBase:RU361128};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU361128};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transferase {ECO:0000256|RuleBase:RU361128}.
FT   DOMAIN       31     79       Phorbol-ester/DAG-type.
FT                                {ECO:0000259|PROSITE:PS50081}.
FT   DOMAIN       94    145       Phorbol-ester/DAG-type.
FT                                {ECO:0000259|PROSITE:PS50081}.
FT   DOMAIN      310    409       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   DOMAIN      499    635       DAGKc. {ECO:0000259|PROSITE:PS50146}.
FT   REGION      178    210       Disordered. {ECO:0000256|MobiDB-lite:
FT                                G3STS1}.
FT   REGION      260    298       Disordered. {ECO:0000256|MobiDB-lite:
FT                                G3STS1}.
FT   REGION      819    850       Disordered. {ECO:0000256|MobiDB-lite:
FT                                G3STS1}.
FT   COMPBIAS    829    850       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                G3STS1}.
SQ   SEQUENCE   850 AA;  92173 MW;  25C8BCC9965802FA CRC64;
     VCNFMSHEKC LKHMKIPCAC VAPSLVRLPA AMCWGPLSLL ERVKFCYLCL KSLEAPALRC
     EVCELHVHPD CVPFACSDCR HCHRDGHQDH DTYHHHWREG NLSSGARCDV CRKTCGSSEM
     LAGLRCEWCG LQAHPVCSSA ITPECSFGRL RSMILPPACV SLVSRNFSKM HCFRIAETPA
     PDPGEGDDSV DGSAVAGPGR EVLASPESSK QTLKIFDGND TVRRNHFRLV TVPRLARSEE
     VLEAALRAYY VSEDPCDFEL QALPPPEQAG ESGARGKART GGAAGDEGSR GPGSRDPVPE
     AWIIRARPRT QEVLRIYPAW LKVGVACVSI RVTPQSTSRT VVLEVLPLLG RQAESPESFQ
     LVEVLMGSRQ VQRTVLADEE PLLDRLRDIR QTSLRQMSQT RFYVAESQAV VPHVSLFIGG
     LPPGLASQEY GPLLQEAVGT KADVVAVSHV YPLAKEASVD RPIFSSPLLG PWAVPPSVAS
     PGRTLSPSLY PEGHMKLPPD CCPLLVFVNP KSGGLKGRDL LCSFRKLLNP HQVFELTNGG
     PLPGFHVFSQ APRFRVLVCG GDGTVGWVLG ALEEILNLPC PGPSVAILPL GTGNDLGRVL
     RWGAGYSGED PFSVLVSVDE ADAVLMDRWT ILLDAHEACG TENSVADVEP PKIVQMNNYC
     GIGIDAELSL DFHQAREEEP GKFTSRYHRR GIHQLGLVEQ GTGAQGLLQA QQRQLPDDSR
     XALSSLHSWG SGADLWGSDN DARFEKPRID DGLLEVVGVT GVVHMGQVQG GLRSGIRIAQ
     GSYFRVTLLK AIPVQVDGEP WVQAPGHIII SAAGPKVHML KKSKQKPRKA GGGPKEARVD
     TFPAPEGDTK
//
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