ID G3SU84_LOXAF Unreviewed; 2098 AA.
AC G3SU84;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Host cell factor C1 {ECO:0000313|Ensembl:ENSLAFP00000003690.4};
GN Name=HCFC1 {ECO:0000313|Ensembl:ENSLAFP00000003690.4};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000003690.4, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000003690.4, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000003690.4,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000003690.4}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000003690.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR Ensembl; ENSLAFT00000004422.4; ENSLAFP00000003690.4; ENSLAFG00000004418.4.
DR GeneTree; ENSGT00940000161383; -.
DR HOGENOM; CLU_002603_0_0_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 6.10.250.2590; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR043536; HCF1/2.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR PANTHER; PTHR46003; HOST CELL FACTOR; 1.
DR PANTHER; PTHR46003:SF3; HOST CELL FACTOR 1; 1.
DR Pfam; PF01344; Kelch_1; 1.
DR Pfam; PF13415; Kelch_3; 1.
DR Pfam; PF13854; Kelch_5; 2.
DR SMART; SM00060; FN3; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR PROSITE; PS50853; FN3; 2.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1860..1951
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1953..2069
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 408..434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1312..1390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1456..1494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1507..1532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1566..1594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2056..2098
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 414..432
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1312..1333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1342..1390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2060..2078
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2098 AA; 215140 MW; F3227E5D20663A44 CRC64;
MASAVSPANL PAVLLQPRWK RVVGWSGPVP RPRHGHRAVA IKELIVVFGG GNEGIVDELH
VYNTATNQWF IPAVRGDIPP GCAAYGFVCD GTRLLVFGGM VEYGKYSNDL YELQASRWEW
KRLKAKTPKN GPPPCPRLGH SFSLVGNKCY LFGGLANDSE DPKNNIPRYL NDLYILELRP
GSGVVAWDIP ITYGVLPPPR ESHTAVVYTE KDNKKSKLVI YGGMSGCRLG DLWTLDIETL
TWNKPSLSGV APLPRSLHSA TTIGNKMYVF GGWVPLVMDD VKVATHEKEW KCTNTLACLN
LDTMAWETIL MDTLEDNIPR ARAGHCAVAI NTRLYIWSGR DGYRKAWNNQ VCCKDLWYLE
TEKPPPPSRV QLVRANTTSL EVSWGAVATA DSYLLQLQKY DIPATAATAT SPTPNPVPSV
PANPPKSPAP AAAAPAVQPL TQVGITLLPQ AAAAPPTTTT IQVLPTVPGS SISVPTAART
QGVPAVLKVT GPQATTGTPL VTMRPASQAG KAPVTVTSLP AGVRMVVPTQ SAQGTVIGSN
PQMSGMAALA AAAAATQKIP PSSAPTVLSV PAGTTIVKTV AVTPGTTTLP ATVKVASSPV
MVSNPATRML KTAAAQVGTS VSSAANTSTR PIITVHKSGT VTVAQQAQVV TTVVGGVTKT
ITLVKSPISV PGGSALISNL GKVMSVVQTK PVQTSAVTGQ ASTGPVTQII QTKGPLPAGT
ILKLVTSADG KPTTIITTTQ ASGAGTKPTI LGISSVSPST TKPGTTTIIK TIPMSAIITQ
AGATGVTSSP GIKSPITIIT TKVMTSGTGA PAKIITAVPK IATGHGQQGV TQVVLKGAPG
QPGTILRTVP MGGVRLVTPV TVSAVKPAVT TLVVKGTTGV TTLGTVTGTV STSLAGAGGH
STSASLATPI TTLGTIATLS SQVINPTAIT VSAAQTTLTA AGGLTTPTIT MQPVSQPTQV
TLITAPSGVE AQPVHDLPVS ILASPTTEQP TATVTIADSG QGDVQPGTVT LVCSNPPCET
HETGTTNTAT TTVVANLGGH AQHPQVQFVC DRQEAAASLV TSTVGQQNGS VVRVCSNPPC
ETHETATTGT TSTATTATSI MAGQPGCSNP PCETHETGTT STATTAMASI GSRQPAAANQ
QRDGRPTYAA STLATGQVSV GAGPAQGAQS SVKPLCQTRQ TSSTHTTMTL MATGMPCSAP
LLAPSLVLEA GCSSTSFAQL APPSGRDGLI ADLGQLVPVG RQLETHHTHT TNTPTTVRST
MGTGEAGEAR GILKPACESH QTSSTGTTVT VTALEALLGP STPVTQVCSN PPCETHETGT
TNTATTSNAG GVQRACANPP CETHETGTTH TATTATSSGG SGQPEGGQQQ APASCPCETH
QTTSTGTTMT VSVGALLPDD GATHRTLEAV LDPVAAPTPV VPQVSPVLLA PFPTQRVCSN
PPCETHETGT THTATTVTSN MSSNQDPPPA VSDQGEVEST QGDSGNIASS SAVTTTVSST
LTRAVTTVTQ STPVPGPSVP RISSMTETTP GALTTEVPIP ATITVTIANT ETSDMPFSAV
DILQPPEDLQ VSPGPRQQLP PRQLLQPAST PLLGEPADTL AATQAPDLQA AVDLSSTGDP
SSGQEPASSA VVATVVVQPP PPTQSEVDQL ALPQELMAEA QAGTTTLMVT GLTPEELAVT
AAAEAAAQAA ATEEAQALAI QAVLQAAQQA VMAGTGEPMD TSDAAATVTQ AELGHLSAEG
QEGQPTTIPI VLTQQELAAL VQQQQLQEAQ AQHHLPTEAL APADSLNDPT IESNCLNELT
AAVPSTVALL PSTATESLAP SNTFVAPQPV VVASPAKLQA AATLTEVANG IETIGVKPDL
PPPPSKTPVK KENQWFDVGV IKGTNVMVTH YFLPPDDAVT SDDDSSTVPD YNQLKKQELQ
PGTAYKFRVA GVNACGRGPF SEISAFKTCL PGFPGAPCAI KISKSPDGAH LTWEPPSVTS
GKIIEYSVYL AIQSTQASGE PKSAAPAQLA FMRVYCGPSP SCLVQSSSLS NAHIDYTTKP
AIIFRIAARN EKGYGPATQV RWLQETSKDS SGTKPASKRP MSSPEMKSAP KKSKADGQ
//
