ID G3SUD9_LOXAF Unreviewed; 645 AA.
AC G3SUD9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Kinetochore protein NDC80 {ECO:0000256|RuleBase:RU368072};
GN Name=NDC80 {ECO:0000313|Ensembl:ENSLAFP00000003759.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000003759.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000003759.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000003759.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000003759.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000003759.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Acts as a component of the essential kinetochore-associated
CC NDC80 complex, which is required for chromosome segregation and spindle
CC checkpoint activity. {ECO:0000256|RuleBase:RU368072}.
CC -!- SUBUNIT: Component of the NDC80 complex.
CC {ECO:0000256|RuleBase:RU368072}.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|RuleBase:RU368072}. Nucleus
CC {ECO:0000256|RuleBase:RU368072}.
CC -!- SIMILARITY: Belongs to the NDC80/HEC1 family.
CC {ECO:0000256|ARBA:ARBA00007050, ECO:0000256|RuleBase:RU368072}.
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DR RefSeq; XP_010585145.1; XM_010586843.1.
DR AlphaFoldDB; G3SUD9; -.
DR STRING; 9785.ENSLAFP00000003759; -.
DR Ensembl; ENSLAFT00000004507.3; ENSLAFP00000003759.3; ENSLAFG00000004506.3.
DR GeneID; 100661800; -.
DR KEGG; lav:100661800; -.
DR CTD; 10403; -.
DR eggNOG; KOG0995; Eukaryota.
DR GeneTree; ENSGT00390000018386; -.
DR HOGENOM; CLU_012583_2_0_1; -.
DR InParanoid; G3SUD9; -.
DR OMA; PSHKFQK; -.
DR OrthoDB; 25325at2759; -.
DR TreeFam; TF101177; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0031262; C:Ndc80 complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0140483; F:kinetochore adaptor activity; IEA:Ensembl.
DR GO; GO:0008017; F:microtubule binding; IEA:Ensembl.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-UniRule.
DR GO; GO:0051298; P:centrosome duplication; IEA:Ensembl.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:Ensembl.
DR GO; GO:0007052; P:mitotic spindle organization; IEA:Ensembl.
DR GO; GO:0090267; P:positive regulation of mitotic cell cycle spindle assembly checkpoint; IEA:Ensembl.
DR Gene3D; 6.10.250.1950; -; 1.
DR Gene3D; 1.10.418.30; Ncd80 complex, Ncd80 subunit; 1.
DR InterPro; IPR040967; DUF5595.
DR InterPro; IPR005550; Kinetochore_Ndc80.
DR InterPro; IPR038273; Ndc80_sf.
DR PANTHER; PTHR10643; KINETOCHORE PROTEIN NDC80; 1.
DR PANTHER; PTHR10643:SF2; KINETOCHORE PROTEIN NDC80 HOMOLOG; 1.
DR Pfam; PF18077; DUF5595; 1.
DR Pfam; PF03801; Ndc80_HEC; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|RuleBase:RU368072};
KW Cell division {ECO:0000256|ARBA:ARBA00022618,
KW ECO:0000256|RuleBase:RU368072};
KW Centromere {ECO:0000256|ARBA:ARBA00023328, ECO:0000256|RuleBase:RU368072};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454, ECO:0000256|RuleBase:RU368072};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838, ECO:0000256|RuleBase:RU368072};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776, ECO:0000256|RuleBase:RU368072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU368072};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 216..288
FT /note="DUF5595"
FT /evidence="ECO:0000259|Pfam:PF18077"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 268..302
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 331..403
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 468..573
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 600..643
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 645 AA; 74027 MW; 2D5BEAB8C0B17BCD CRC64;
MKRSSVSTGG AGRLSVQELR SQDLNKQGLY TPQNKEKSAF GKLSLNKPTS STSERKVSVF
GKRTSGTGSR NSQFGIFSSS EKIKDPRPLN DKAFIQQCIR QLCEFLTENG YAYSISMKSL
QAPSVKDFLK IFTFLYGFLC PSYELPDTKF EEEVPRIFKD LGYPFALSKS SMYTVGAPHT
WPHIVAALVW LIDCIKLYTA MKESSPSFDD GQPWGEETED GIMHNKLFLD YTIKCYESFM
TGADSFEEMN TELQSKLKDL FNVDASKLES LAAKNKALNE QIARLERERE KEPNRLESLR
KLKGSLQADV QKYQAYMSNL ESHSAILDQK LNGLDEDIAR VEIECETVKQ ENTRLQNIVD
NQKYSVADIE RINHERNELQ QTINKLTKDL QAEQQQLWNE ELKYARGKET IEAQLAEYHK
LARKLKLIPK GAENSKGYDF EIKFNPEAGA NCLVKYKAQV YAPLKELLNQ TEEEINKVLN
KKMGLEDTLE QLNIMVTESK RSVRTLKEEV QKLDDLYQHK VKEAEEEDKK CANELESLEK
HKHLLESGVN EGLSEAMNEL DTIQREYQLV VQTTSEERRK VGNNLQRLLE MVATHVGSVE
KHLEEQLAKV DREYEEYMSE DILENIREIA DKYKKKAALL KASDE
//
