ID G3SVU6_LOXAF Unreviewed; 740 AA.
AC G3SVU6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Scm like with four mbt domains 2 {ECO:0000313|Ensembl:ENSLAFP00000004390.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000004390.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000004390.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000004390.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000004390.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000004390.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; G3SVU6; -.
DR STRING; 9785.ENSLAFP00000004390; -.
DR Ensembl; ENSLAFT00000005244.3; ENSLAFP00000004390.3; ENSLAFG00000005244.3.
DR eggNOG; KOG3766; Eukaryota.
DR GeneTree; ENSGT00940000158123; -.
DR HOGENOM; CLU_005352_0_1_1; -.
DR InParanoid; G3SVU6; -.
DR OMA; NMSEPFH; -.
DR TreeFam; TF316498; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0042393; F:histone binding; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR CDD; cd20114; MBT_SFMBT2_rpt2; 1.
DR CDD; cd20116; MBT_SFMBT2_rpt3; 1.
DR CDD; cd20118; MBT_SFMBT2_rpt4; 1.
DR CDD; cd09581; SAM_Scm-like-4MBT1_2; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 3.90.1150.190; SLED domain; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR004092; Mbt.
DR InterPro; IPR047354; MBT_SFMBT2_rpt3.
DR InterPro; IPR047355; MBT_SFMBT2_rpt4.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR037604; Scm-like-4MBT1/2_SAM.
DR InterPro; IPR021987; SLED.
DR InterPro; IPR038348; SLED_sf.
DR PANTHER; PTHR12247; POLYCOMB GROUP PROTEIN; 1.
DR PANTHER; PTHR12247:SF62; SCM-LIKE WITH FOUR MBT DOMAINS PROTEIN 2; 1.
DR Pfam; PF02820; MBT; 3.
DR Pfam; PF00536; SAM_1; 1.
DR Pfam; PF12140; SLED; 1.
DR SMART; SM00561; MBT; 3.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 3.
DR PROSITE; PS51079; MBT; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 6..110
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 120..226
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT REPEAT 234..331
FT /note="MBT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00459"
FT DOMAIN 651..734
FT /note="PNT"
FT /evidence="ECO:0000259|SMART:SM00251"
FT DOMAIN 667..733
FT /note="SAM"
FT /evidence="ECO:0000259|SMART:SM00454"
FT REGION 526..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..553
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 566..587
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 598..613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..638
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 740 AA; 84188 MW; 155CD77A791CF501 CRC64;
IKEKYTDWTE FLIRDLTGSR TAPANLLEGP LRGKGPIDLI TVDSLIELQD SQNPFQYWIV
SVIENVGGRL RLRYVGLEDT ESYDQWLFYL DYRLRPVGWC QENKYRMDPP SEIYPLKMAS
EWKHALEKSL IDAAKFPLPM EVFKDHADLR SHFFTVGMKL ETVNMSEPFH ICPASVTKVF
NNHFFQVTID DLRPEPSKRS MLCHMDSLGI LPVQWCLKNG VNLLPPKGYS GQDFDWADYH
KQHGAEAAPP FCFRNTLLSR GFSKNMKLEA VNPTNPGELC VASVVSVKGR LMWLHLEGLQ
TPVPEFIVDV DSMDIFPVGW CEANSYPLTT PHKAGSQMKR KIAVVQPEKH MAMTRTKHPP
PKKRLPSTVP GTVNGKYCCP QLFINHRCFS GPYLNKGRIA ELPQSVGPGK CVLVLKEVLS
MIINAAYKPG RVLRELQLVE DPNWNFQEET LKAKYRGKTY RAVVKIVRTS DQVADFCRRV
CAKLECCPNL FSPVLVSENC PENCSIHTKT KYTYYYGKRK KIIKPPIGEN SVESGPPKPA
RRRKRRKSIF VQKKRRSSTV DFTTLSGEES EEEDPDVVED DTGSEETGSE LRDDQTDTSS
VEVPSTRPRR AVTLRSSSEP ERRPPVERTR RGRKAQTASC AGEDKCTPAK QETKQEEEER
LVLESNPLEW TVTDVVRFIK LTDCAPLAKI FQEQDIDGQA LLLLTLPTVQ ECMELKLGPA
IKLCHQIERV KVAFYAQYAN
//
