ID   G3SWM4_LOXAF            Unreviewed;       494 AA.
AC   G3SWM4;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 64.
DE   RecName: Full=Spermatogenesis-defective protein 39 homolog {ECO:0000256|ARBA:ARBA00019368};
DE   AltName: Full=VPS33B-interacting protein in apical-basolateral polarity regulator {ECO:0000256|ARBA:ARBA00029984};
DE   AltName: Full=VPS33B-interacting protein in polarity and apical restriction {ECO:0000256|ARBA:ARBA00031270};
GN   Name=VIPAS39 {ECO:0000313|Ensembl:ENSLAFP00000004737.3};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000004737.3, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000004737.3, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000004737.3,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000004737.3}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000004737.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|ARBA:ARBA00004412}.
CC       Endosome {ECO:0000256|ARBA:ARBA00004177}.
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DR   RefSeq; XP_003408842.1; XM_003408794.2.
DR   RefSeq; XP_010587080.1; XM_010588778.1.
DR   AlphaFoldDB; G3SWM4; -.
DR   STRING; 9785.ENSLAFP00000004737; -.
DR   Ensembl; ENSLAFT00000005645.3; ENSLAFP00000004737.3; ENSLAFG00000005645.3.
DR   GeneID; 100656292; -.
DR   KEGG; lav:100656292; -.
DR   CTD; 63894; -.
DR   eggNOG; KOG4677; Eukaryota.
DR   GeneTree; ENSGT00390000013955; -.
DR   HOGENOM; CLU_029487_0_0_1; -.
DR   InParanoid; G3SWM4; -.
DR   OMA; YWNRSSR; -.
DR   OrthoDB; 2945298at2759; -.
DR   TreeFam; TF319640; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR   GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
DR   GO; GO:0099023; C:vesicle tethering complex; IEA:Ensembl.
DR   GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
DR   GO; GO:0030199; P:collagen fibril organization; IEA:Ensembl.
DR   GO; GO:0032963; P:collagen metabolic process; IEA:Ensembl.
DR   GO; GO:0008333; P:endosome to lysosome transport; IEA:Ensembl.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:Ensembl.
DR   GO; GO:0043687; P:post-translational protein modification; IEA:Ensembl.
DR   InterPro; IPR040057; Spe-39.
DR   InterPro; IPR006925; Vps16_C.
DR   PANTHER; PTHR13364; DEFECTIVE SPERMATOGENESIS PROTEIN 39; 1.
DR   PANTHER; PTHR13364:SF6; SPERMATOGENESIS-DEFECTIVE PROTEIN 39 HOMOLOG; 1.
DR   Pfam; PF04840; Vps16_C; 1.
PE   4: Predicted;
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT   DOMAIN          178..279
FT                   /note="Vps16 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF04840"
FT   REGION          41..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        65..84
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   494 AA;  57052 MW;  2D745E616385C642 CRC64;
     MNRTKGDEEE YWNSSKFKAF TFDDEDDELS QLKESKRAVN SLRDFVGDDD DDDDDLERVS
     WSGEPVGSIS WTIKETAGNS GSTHEGREQK NRNNFSSYGQ PSKPISTYSL SSFFKGRTRF
     GSFQSLSDAL SDTSAKSYAP ELGRPKGEYR DYSNDWSLSD TVQRLRKGKV CSLERFRSLQ
     DKLQLLEEAV SMHDGNVITA VLIFLKRTLS KEILFRELEV RQVALRHLIH FLKEIGDQKL
     LLDLFRFLDR TEELALSHYQ EHLNIQDPEK RKEFLKTCIG LPFSAEDSAH IQDHYTLLER
     QIIIETIDRH LESAGQTEIF RKHPRKASIL NMPLVTTLFY SCFYHYTEAE GTFSSPINLK
     KTFKIPDKQY VLTALAARAK LRAWHDVDAL FTTKNWLGYT KKRAPIGFHR VVEILHKNSA
     PVQILQEYVN LVEDVDTKLN LATKFKCHDV VIDTCRDLKD RQQLVAYRSK VDKGSAEEEK
     IDAILNSAQI RWKN
//