ID G3SX52_LOXAF Unreviewed; 457 AA.
AC G3SX52;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=GDNF family receptor alpha-1 {ECO:0000256|PIRNR:PIRNR038071};
DE Short=GDNF receptor alpha-1 {ECO:0000256|PIRNR:PIRNR038071};
GN Name=GFRA1 {ECO:0000313|Ensembl:ENSLAFP00000004958.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000004958.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000004958.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000004958.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000004958.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000004958.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for GDNF. Mediates the GDNF-induced
CC autophosphorylation and activation of the RET receptor.
CC {ECO:0000256|PIRNR:PIRNR038071}.
CC -!- SUBUNIT: 2 molecules of GDNFR-alpha are thought to form a complex with
CC the disulfide-linked GDNF dimer and with 2 molecules of RET.
CC {ECO:0000256|PIRNR:PIRNR038071}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}.
CC -!- SIMILARITY: Belongs to the GDNFR family.
CC {ECO:0000256|ARBA:ARBA00005961, ECO:0000256|PIRNR:PIRNR038071}.
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DR AlphaFoldDB; G3SX52; -.
DR STRING; 9785.ENSLAFP00000004958; -.
DR Ensembl; ENSLAFT00000005913.3; ENSLAFP00000004958.3; ENSLAFG00000005913.3.
DR eggNOG; ENOG502QQA2; Eukaryota.
DR GeneTree; ENSGT00940000155560; -.
DR HOGENOM; CLU_040179_1_1_1; -.
DR InParanoid; G3SX52; -.
DR OMA; FFQDNIC; -.
DR TreeFam; TF331647; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007399; P:nervous system development; IEA:Ensembl.
DR Gene3D; 1.10.220.110; GDNF binding domain; 1.
DR InterPro; IPR016017; GDNF/GAS1.
DR InterPro; IPR037193; GDNF_alpha.
DR InterPro; IPR003438; GDNF_rcpt.
DR InterPro; IPR003503; GDNF_rcpt_A1.
DR InterPro; IPR017372; Glial_neurotroph_fac_rcpt_a1/2.
DR PANTHER; PTHR10269:SF3; GDNF FAMILY RECEPTOR ALPHA-1; 1.
DR PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR Pfam; PF02351; GDNF; 3.
DR PIRSF; PIRSF038071; GDNF_family_receptor_alpha; 1.
DR PRINTS; PR01317; GDNFRALPHA1.
DR PRINTS; PR01316; GDNFRECEPTOR.
DR SMART; SM00907; GDNF; 3.
DR SUPFAM; SSF110035; GDNF receptor-like; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|PIRNR:PIRNR038071};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor {ECO:0000256|ARBA:ARBA00022622};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038071};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR038071};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 21..103
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 145..224
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 234..328
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
SQ SEQUENCE 457 AA; 50456 MW; 2731A2A0A8E2868D CRC64;
VLGPADLLLS AEVSGGDRLD CVKASDQCLK EQSCSTKYRT LRQCVAGKET NFSLASGLEA
KDECRNAMEA LKQKSLYNCR CKRGMKKEKN CLRIYWSMYQ SLQGNDLLED SPYEPVNSRL
SDIFRVVPFI PACFAVEHIP KGNNCLDAAK ACNLDDTCKK YRSAYITPCT TSMSNEVCNR
RKCHKALRQF FDKVPAKHSY GMLFCSCRDI ACTERRRQTI VPVCSYEERE KPNCLHLQDS
CKMNYICRSR LADFFTNCQP ESRSVSSCLK ENYADCLLAY SGLIGTVMTP NYIDSSSLSV
APWCDCNNSG NDLDECLKFL NFFKDNTCLK NAIQAFGNGS DVTVWQPAFP VQTTTATTTT
AFRVKNKPLG PPGSANEIPT HVLPPCANLQ AQKLKSNVSG STHLCLSDRD YEKDGLAGAS
SHITTKSMAA PPSCSPCPLL VLVVTALSTL LSLSLAE
//
