ID G3SXI1_LOXAF Unreviewed; 531 AA.
AC G3SXI1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Keratin 5 {ECO:0000313|Ensembl:ENSLAFP00000005117.3};
GN Name=KRT5 {ECO:0000313|Ensembl:ENSLAFP00000005117.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000005117.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000005117.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000005117.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000005117.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000005117.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR AlphaFoldDB; G3SXI1; -.
DR Ensembl; ENSLAFT00000006104.3; ENSLAFP00000005117.3; ENSLAFG00000006104.3.
DR GeneTree; ENSGT00940000160458; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR032444; Keratin_2_head.
DR InterPro; IPR003054; Keratin_II.
DR PANTHER; PTHR45616; GATA-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45616:SF14; KERATIN, TYPE II CYTOSKELETAL 2 EPIDERMAL; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF16208; Keratin_2_head; 2.
DR PRINTS; PR01276; TYPE2KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 117..430
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 503..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 172..255
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 342..408
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 509..531
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 531 AA; 56976 MW; C5ED2380BB499D79 CRC64;
MSCQISCRPC GPLGFSSGSA LAFCGSRRSG FSFPCLSRHG GGGRGFGSWS LVGLGGTKSI
SASVAGGGRS FGSRGGFICG PGGLPGGGIH EVSINQSLLQ PLNVKVDPEI QNVKSQEREQ
IKILNNKFAC FIDKVRFLEQ QNQVLRTKWE FLQQIDGDTC IINLDPIFQA YIANLKKKVD
VLCAERASQE SELCHVQDLV EDYKKKYEDE VNKRTCAEND FVTLKKDVDN AYLNKVELQA
KADVLNQEVE FLKILFDAEL SQRRQTITDT NVILSMDNSR SLDLDCIIAE VQAQYEEIAL
KSKVEAEALY QSKYEELQVT AGKHGDCLKE IKVEICELNR LIQRLQGEIA HVKKQCKSVQ
DAIAEAEQKG EHALKDARQK LVELEEALQQ AREDMARLLR DYQELMNTKL ALDVEIATYR
KLLEGEECRM SGDLSSCVTM SVTSSTISSN VASKAGIGHC GPEGRGFSSG GGGYSSASSS
YGFGGRGSSS KGGSGGGYCS GGGSRGGSGS GGGASSSEKG CSGAAESCGS G
//
