ID G3T0K8_LOXAF Unreviewed; 846 AA.
AC G3T0K8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=B-cell receptor CD22 {ECO:0000256|ARBA:ARBA00040106};
DE AltName: Full=Sialic acid-binding Ig-like lectin 2 {ECO:0000256|ARBA:ARBA00041781};
GN Name=CD22 {ECO:0000313|Ensembl:ENSLAFP00000006512.3};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000006512.3, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000006512.3, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000006512.3,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000006512.3}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000006512.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; G3T0K8; -.
DR STRING; 9785.ENSLAFP00000006512; -.
DR Ensembl; ENSLAFT00000007755.3; ENSLAFP00000006512.3; ENSLAFG00000007755.3.
DR eggNOG; KOG4475; Eukaryota.
DR GeneTree; ENSGT01010000222294; -.
DR HOGENOM; CLU_017949_0_0_1; -.
DR InParanoid; G3T0K8; -.
DR OMA; GCYICNA; -.
DR TreeFam; TF334827; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0032809; C:neuronal cell body membrane; IEA:Ensembl.
DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
DR GO; GO:0042609; F:CD4 receptor binding; IEA:Ensembl.
DR GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
DR GO; GO:0033691; F:sialic acid binding; IEA:Ensembl.
DR GO; GO:0042113; P:B cell activation; IEA:Ensembl.
DR GO; GO:0050859; P:negative regulation of B cell receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0050849; P:negative regulation of calcium-mediated signaling; IEA:Ensembl.
DR GO; GO:0002638; P:negative regulation of immunoglobulin production; IEA:Ensembl.
DR GO; GO:0030888; P:regulation of B cell proliferation; IEA:Ensembl.
DR GO; GO:0030100; P:regulation of endocytosis; IEA:Ensembl.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 6.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR46958; B-CELL RECEPTOR CD22; 1.
DR PANTHER; PTHR46958:SF1; B-CELL RECEPTOR CD22; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00409; IG; 7.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 7.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..846
FT /note="B-cell receptor CD22"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003454440"
FT TRANSMEM 687..705
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 147..234
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 241..325
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 330..413
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 418..485
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 504..581
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 592..675
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 846 AA; 94974 MW; 33F39274F25F748B CRC64;
PRHDTMRLFG PSLLLLEYLA FSDSASWKVD HPGTLYSWEG ACVWIPCLYK TPYRSKPLES
FTVYHNFKYD NITKNFTGTI LYTNKEALPY PEKSRVEFLG NYKNNCSLHI KTVHVNDSGQ
LGLRMTAGTD KWMEPINLNV SEKPPPPHIQ LPLEIQESQE VTLTCSLNFT CPGYQIQLQW
SLEESAVTLI SMDPKTVSTE SKLTFHPNWT HHGQNLTCQL KDNSGEMLSQ EMVQLNVNHS
PKLKIEISSG KATVMEGESV IFTCLVISSN PEHGDISWFK DSTKLIMQKT NVLTLSTVTK
RDSGKYHCQS FNSVGAGKSE DVVLHVQFTP EPSSVQIVPS PANEGEMVEL TCTSLAYPPP
TNYTWYHNGQ EVQGRREKNF QIPKLLLCHA GNYSCLAENS LGPGEIGQEA ELDIQYAPKG
VTMVIQNPTP IREGDDVTLV CNYNSSNPRV TEYKWKPEAS KNKSFPEVMM IRKVTWDVKP
ITCEACNLWC SKAPFVTLDV HYAPKDVRVM KISPRTEIHS GHPVLLRCDF SRSHPMDVRF
FWKKNGSFLE EGQELSFDSI SPEDAGHYSC LVNNSIGQTT SEAWMLQVLY KPRGLRVSIA
PQDRVMEGKK ATLTCESDAN PPVSWYTWFD WNNQNLHHAA QTLRLEPVNV KHSGAYWCQG
NNQLGMGQSP PSTLTVYYSP ETIGKRAALG IGVCLSIFIL AIWGVKVYRS WKKIREQQEL
QENSSGQSFF VKNKKIRRAG LSEGPHSLGC YNPAMEDGIS YAALRFPFGE TDTPGADDVG
TSASVSNMED MVTYSVVQKR RVGDYENVAP AFAEDEEGIH YSELVHLGSG ERPPAQEGVE
YVTLKP
//
