ID G3T0Z3_LOXAF Unreviewed; 564 AA.
AC G3T0Z3;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Rhotekin {ECO:0000313|Ensembl:ENSLAFP00000006697.4};
GN Name=RTKN {ECO:0000313|Ensembl:ENSLAFP00000006697.4};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000006697.4, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000006697.4, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000006697.4,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000006697.4}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000006697.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003413738.1; XM_003413690.2.
DR AlphaFoldDB; G3T0Z3; -.
DR STRING; 9785.ENSLAFP00000006697; -.
DR Ensembl; ENSLAFT00000007985.4; ENSLAFP00000006697.4; ENSLAFG00000007986.4.
DR GeneID; 100656880; -.
DR KEGG; lav:100656880; -.
DR CTD; 6242; -.
DR eggNOG; ENOG502QRWR; Eukaryota.
DR GeneTree; ENSGT00940000158491; -.
DR InParanoid; G3T0Z3; -.
DR OMA; CMTQPSA; -.
DR OrthoDB; 5393023at2759; -.
DR TreeFam; TF331476; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005095; F:GTPase inhibitor activity; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:Ensembl.
DR CDD; cd13249; PH_rhotekin2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR012966; AHD.
DR InterPro; IPR011072; HR1_rho-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR21538; ANILLIN/RHOTEKIN RTKN; 1.
DR PANTHER; PTHR21538:SF19; RHOTEKIN; 1.
DR Pfam; PF08174; Anillin; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00742; Hr1; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51860; REM_1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01207};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646}.
FT DOMAIN 17..98
FT /note="REM-1"
FT /evidence="ECO:0000259|PROSITE:PS51860"
FT DOMAIN 309..416
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 96..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 517..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 564 AA; 62541 MW; 60CCFDC4F9090C6E CRC64;
MFARNHRSRV TVARGSALEM EFKRGRFRLS LFSEPPEDTE LQRKLDHEIR MREGACKLLA
ACSQREQALE ATKSLLVCNS RILSYMGELQ RRKEAQVLGK TARRPSDSGP PADRSPCRGR
VCISDLRIPL MWKDTEYFKN KGDLHRWAVF LLLQLGEHIE DTEMVLVDRT LTDITFQNSV
LFADAGPDFE LRLELYGACV EEEGALTTAP KRLATKLSSS LGRSSGRRVR ASLDSAGGSG
SSPILLPTLA VGGPRYHLLA HTTLTLAAVQ DGFRTHDLTL TSHEENPAWL PLYGSVCCRL
VAQPLCMTQP TASGTLRVQQ AGELQSWAQV HGVLKGTNLF CYRRPEDTDT GEEPLFTIVI
SKDTRVRAGE LDQAPGRPFT LSISNQYGDD KVMHTLQTES RGALQSWMEA LWQLFFDMSQ
WKQCCDEIMK IETPAPRKPP QAVAKQGSLY HEMAIEPLDD IAAVTDILAQ REGPRLETPP
PWLAMFTDQP ALPSPCSPAS VAPAQARTHP LLWGRPRTFS LDAVPPDHSP GASRSVAPLP
SQRSPRSRGL CSKGPPHTWL QSPV
//
