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Database: UniProt
Entry: G3T133_LOXAF
LinkDB: G3T133_LOXAF
Original site: G3T133_LOXAF 
ID   G3T133_LOXAF            Unreviewed;      1238 AA.
AC   G3T133;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   05-JUN-2019, entry version 46.
DE   SubName: Full=Cell adhesion associated, oncogene regulated {ECO:0000313|Ensembl:ENSLAFP00000006747};
GN   Name=CDON {ECO:0000313|Ensembl:ENSLAFP00000006747};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000006747, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000006747}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000006747};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000006747}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000006747};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   STRING; 9785.ENSLAFP00000006747; -.
DR   Ensembl; ENSLAFT00000008048; ENSLAFP00000006747; ENSLAFG00000008045.
DR   eggNOG; ENOG410IHIH; Eukaryota.
DR   eggNOG; ENOG410XSVT; LUCA.
DR   GeneTree; ENSGT00940000157114; -.
DR   InParanoid; G3T133; -.
DR   OMA; VVGSWHT; -.
DR   TreeFam; TF332268; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
DR   GO; GO:0001708; P:cell fate specification; IEA:Ensembl.
DR   GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
DR   GO; GO:0010172; P:embryonic body morphogenesis; IEA:Ensembl.
DR   GO; GO:0060059; P:embryonic retina morphogenesis in camera-type eye; IEA:Ensembl.
DR   GO; GO:0002088; P:lens development in camera-type eye; IEA:Ensembl.
DR   GO; GO:0007520; P:myoblast fusion; IEA:Ensembl.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR   GO; GO:0045663; P:positive regulation of myoblast differentiation; IEA:InterPro.
DR   GO; GO:2000179; P:positive regulation of neural precursor cell proliferation; IEA:Ensembl.
DR   GO; GO:0045666; P:positive regulation of neuron differentiation; IEA:Ensembl.
DR   GO; GO:0048643; P:positive regulation of skeletal muscle tissue development; IEA:Ensembl.
DR   GO; GO:0051057; P:positive regulation of small GTPase mediated signal transduction; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0043497; P:regulation of protein heterodimerization activity; IEA:Ensembl.
DR   GO; GO:0014816; P:skeletal muscle satellite cell differentiation; IEA:Ensembl.
DR   GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR   CDD; cd00063; FN3; 3.
DR   Gene3D; 2.60.40.10; -; 8.
DR   InterPro; IPR032983; CDO.
DR   InterPro; IPR003961; FN3_dom.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   PANTHER; PTHR44170:SF1; PTHR44170:SF1; 1.
DR   Pfam; PF00041; fn3; 3.
DR   Pfam; PF07679; I-set; 1.
DR   SMART; SM00060; FN3; 3.
DR   SMART; SM00409; IG; 5.
DR   SMART; SM00408; IGc2; 5.
DR   SUPFAM; SSF48726; SSF48726; 5.
DR   SUPFAM; SSF49265; SSF49265; 2.
DR   PROSITE; PS50853; FN3; 3.
DR   PROSITE; PS50835; IG_LIKE; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Repeat {ECO:0000256|SAAS:SAAS00923712};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    938    963       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        4     89       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN       99    179       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      200    278       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      285    371       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      380    491       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      554    652       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      697    792       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   DOMAIN      800    900       Fibronectin type-III.
FT                                {ECO:0000259|PROSITE:PS50853}.
FT   REGION      508    562       Disordered. {ECO:0000256|MobiDB-lite:
FT                                G3T133}.
FT   REGION      649    673       Disordered. {ECO:0000256|MobiDB-lite:
FT                                G3T133}.
FT   REGION      910    931       Disordered. {ECO:0000256|MobiDB-lite:
FT                                G3T133}.
FT   REGION     1213   1238       Disordered. {ECO:0000256|MobiDB-lite:
FT                                G3T133}.
FT   COMPBIAS    521    549       Polar. {ECO:0000256|MobiDB-lite:G3T133}.
FT   COMPBIAS    649    663       Polar. {ECO:0000256|MobiDB-lite:G3T133}.
FT   COMPBIAS    913    931       Polar. {ECO:0000256|MobiDB-lite:G3T133}.
FT   COMPBIAS   1220   1238       Polar. {ECO:0000256|MobiDB-lite:G3T133}.
SQ   SEQUENCE   1238 AA;  134561 MW;  35D2B7F63A3E0718 CRC64;
     DLTPSFISEP LSAVQKLGGP VVLHCSAKPV TAQISWLLNG KRLDRNTDQI KMRQGTLTIP
     SLNPSLSGSY QCIANNSIGA IVSGPAVVST AVLGDFGSPT KNVITAEEKS TAFIGCKVPD
     SNPKAEVRYK IRGKWLKHST DNYLILPSGN LQILNVSSED RGSYKCAVYN PVTQELKVEP
     IGRKLLVSRP SSDDFHILHP TLSQALAVLS YSPVTLECVV RGVPASQVYW LKDGQDVVLG
     SNWRRLYSHL ATDSIDPGDA GNYSCVVGNR SGDLKHVTYM VNVLERASIS EGLQDQMVSL
     GATVHFTCDV HGNPVPNRTW FHNARPIHPS PRHLTTGNGL EISGVTMEDS GLYQCIADNG
     IGFVQSTGRL DIEKDSGFKP VIITAPASAK VVDGDIVTLS CNATGLPVPV IRWYDSHGLI
     TSHPSQILRS KSRKSHLVRP EAVNLEPVYF IMSRAGSSSL YIQAVTQEHA GKYICEATND
     HGTVYSEAFI TVVPFETNTK AETVTLSDAA QSDDRETRNV SEAGSLSSLP VKSRSSAVES
     SSVKNASSAS VPDAPIILSP PQTHTPDTYN LVWRSGKDGG LPINAYFVKY RKLDDAVGVV
     GSWHTVRVPG SENELHLTEL EPSSLYEVLM VARSAAGEGQ PAMLTFRTSK EKTASSKNTQ
     ASAPPMGIPK HPVDSEVTNN FGVVLTDSSR HSGVPEAPDR PTISTASETS VYVTWIPRAN
     GGSPITAFKV EYKRMRSSDW LVAAEDIPPS KLSVEVRSLE PGSTYKFRVI AINHYGESFR
     SSASRPYQVA GFSNRFSNRP ITGPHIAYTE AVSDTEIMLK WTYIPSSNNN TPIQGFYIYY
     RPTDSDNDSD YKRDVVEGSK QWHMIGHLQP ETSYDIKMQC FNEGGESEFS NVMICETKVK
     RVPGASEYPV RDLSTPPNFS GSGGNVGPAT SPTRSSDMLY LIVGCVLGVM VLILMVFIAM
     CLWRNRQQST IQKYDPPGYL YQGSDVNGQV VEYTTLPGTS RVNGHVHGSI MRNGSLSNGC
     SHLHHKVSNG VNAFVNGSLN GGLCSGHTNT LARTRVDFEH PHHLLNGAGM YKAVPQTDPL
     ECVNCRNCRN NNRCFTKTNS TFSSSPLPLV RVVAPYSQDA LEMKPLSHMK MPVCLASTAP
     ECGHLSQESI KDNVAPASTQ HTCCQDSINE INSGCTEDTA EFNRGDSCVH SERENTILSW
     NPLILPPVSK DCTEKTAWSP PSIPLDSPSG VLQQPQET
//
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