ID G3T1Q6_LOXAF Unreviewed; 947 AA.
AC G3T1Q6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=GEM interacting protein {ECO:0000313|Ensembl:ENSLAFP00000007040.2};
GN Name=GMIP {ECO:0000313|Ensembl:ENSLAFP00000007040.2};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000007040.2, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000007040.2, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000007040.2,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000007040.2}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000007040.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3T1Q6; -.
DR STRING; 9785.ENSLAFP00000007040; -.
DR Ensembl; ENSLAFT00000008392.2; ENSLAFP00000007040.2; ENSLAFG00000008389.2.
DR eggNOG; KOG1453; Eukaryota.
DR GeneTree; ENSGT00950000183110; -.
DR HOGENOM; CLU_006236_1_0_1; -.
DR InParanoid; G3T1Q6; -.
DR OMA; QYMLGLD; -.
DR TreeFam; TF351450; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
DR CDD; cd20816; C1_GMIP-like; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228:SF16; GEM-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 85..353
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 496..540
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 557..740
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 45..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 885..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..271
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..787
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 947 AA; 103995 MW; 2A5AE2281C9C156E CRC64;
MDAAQPGLPP APEGRKRYSD IFRSLDNLEI SLGNVTLEML AGDPVLSGDP EPDKAPTATV
MREQTSETSC WSSPSPEGPA PLTGEELDLR LIRTKGGVDA ALEYAKTWSR YAKELLAWTE
KRASHELEFA KSIMKIAEAG KGSIYQQSHM PLQYIYTLFL EHDLTLGALT QETVAQQRRD
YYQPLVAKRT EIEKWRKEFK EQWIKEQKRM VRPGNEACAR GLRRAQLQVQ YIQRSEDLQR
SQGPRDPAPQ ASQGPASKQE RRRRSREEAQ AKAQEAEALY QACVREANAR QQDLEAAKQR
IVSHVRKLVL QGDEVLKRVT LGLFGLRGAQ AEHGPRAFAA LAECCAPFEP GQRYQEFVRA
MRPEAPPPPP PAFSFQEFVP AAHSSPPDTR KKLSAPLPPR LDEGAAEPGP WEDTSLRWQG
TPGSDVESVG GSSESRSLDS PTSSPGPGSR RLVKASSTGT ESSDDFEERD PDLGDGLENG
MAGPFRKWTL SSAAQTHRLR RLRGPAKCRE CEAFMVSGTE CEECFLTCHK RCLETLLILC
GHKRLPARTP LFGVDFLQLP RDFPEEVPFL VTRCTAEIEH RALGVQGIYR VSGSRVRVER
LCQAFENGRA LVELSGNSPH DVSGVLKRFL QELTDPVVLW VLIPDLGHMP ADLKQCPKPL
LRELGTSPLR ALPLTVPRVA AQFEENKMSA NNLGIVFGPT LLRPPDSSGA AGAGPVVCLL
DSGHQAQLVE FLIVHYEQIF GMDELPLATE PPFHNPSPAP GDLTTSLQPE PPYLIQDPVP
PALASDPGPD SEPQSVLEKH PEAVSPESPT LQSDQREEVA TDTRDGGGEA SNRGPEDSLL
GTQPRGHFSR QPVKYPRGGV RPVTHQLSSL ALVASKLCEE TPVTAVPHGS LRGRGAGPAA
SSPEGSPLRR TPLPKHFEIT QETARLLSKL HSDAVPRTTC CMDPQPE
//
